Toll-Like Receptor Expression in Irritable Bowel Syndrome: On the Alert for a Microbial Threat?

2011 ◽  
Vol 106 (2) ◽  
pp. 337-339 ◽  
Author(s):  
Giovanni Barbara
Keyword(s):  
Irritable Bowel Syndrome ◽  
Receptor Expression ◽  
Toll Like Receptor ◽  
Irritable Bowel

scholarly journals The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression

2016 ◽  
Vol 69 ◽  
pp. 67-76 ◽  
Author(s):  
Elizabeth J. Videlock ◽  
Wendy Shih ◽  
Mopelola Adeyemo ◽  
Swapna Mahurkar-Joshi ◽  
Angela P. Presson ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Glucocorticoid Receptor ◽  
Hpa Axis ◽  
Receptor Expression ◽  
Irritable Bowel

scholarly journals Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Song Jizhong ◽  
Wang Qiaomin ◽  
Wang Chao ◽  
Li Yanqing
Keyword(s):  
Gene Expression ◽  
Irritable Bowel Syndrome ◽  
Inflammatory Response ◽  
Psychiatric Symptoms ◽  
Corticotropin Releasing Factor ◽  
Low Grade ◽  
Lower Grade ◽  
Toll Like Receptor ◽  
Irritable Bowel ◽  
Low Grade Inflammation

The mechanism of low-grade inflammation in irritable bowel syndrome (IBS) is unclear; our research concentrates on the involvement of the corticotropin-releasing factor (CRF) and Toll-like receptor (TLR) gene expression in the process of low-grade inflammation in IBS patients with depression. This study suggests more IBS patients are presenting with the states of depression and anxiety. IBS patients with depression have shown a lower grade inflammatory response and an imbalance of the inflammatory response. CRF1, CRF2, TLR2, and TLR4 in IBS patients with depression are significantly higher than those without depression and controls. Thus, activation of the CRF-TLR associated pathways produces an inflammatory reaction, which can concurrently affect the digestive tract and the CNS and induce the corresponding digestive and psychiatric symptoms.

scholarly journals Comparison of Electroacupuncture and Moxibustion for Relieving Visceral Hypersensitivity in Rats with Constipation-Predominant Irritable Bowel Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ji-Meng Zhao ◽  
Liu Chen ◽  
Ci-Li Zhou ◽  
Yin Shi ◽  
Yu-Wei Li ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visceral Hypersensitivity ◽  
Receptor Expression ◽  
Blue Staining ◽  
Toluidine Blue Staining ◽  
Treatment Groups ◽  
Analgesic Effects ◽  
Colorectal Distention ◽  
Irritable Bowel ◽  
Better Than

Aim. To compare whether there is different effect between electroacupuncture (EA) and moxibustion (Mox) on visceral hypersensitivity (their analgesic effects) in constipation-predominant irritable bowel syndrome (C-IBS).Methods. EA at 1 mA and 3 mA and Mox at 43°C and 46°C were applied to the Shangjuxu (ST37, bilateral) acupoint in rats with C-IBS and normal rats. An abdominal withdrawal reflex (AWR) score was used to assess visceral hypersensitivity. Toluidine blue staining was used to assess mast cell (MC) activity in colon of rats. Immunochemistry was used to measure 5-HT and 5-HT4 receptor expression in the colon.Results. AWR scores in all EA (1 mA and 3 mA) and Mox (43°C and 46°C) treatment groups after colorectal distention (CRD) stimulation pressure of 20, 40, 60, and 80 mmHg were significantly lower than those of the model (MC) group (Pall < 0.01). The MC counts and degranulation rates in the colon of all EA and Mox treatment groups and the MC group were significantly higher than those of the NC group (Pall < 0.01). MC degranulation rates in the colon of all EA and Mox treatment groups were lower than those of the MC group (Pall < 0.05). 5-HT expression in colon of all EA and Mox treatment groups was significantly lower than that of the MC group (Pall < 0.01), and 5-HT4R expression in colon of both EA groups was significantly higher than that of the MC group (Pboth < 0.01).Conclusion. EA and Mox treatments may both ameliorate visceral hypersensitivity at different degree in rats with C-IBS, and EA treatment was better than Mox.

244 Enhanced Stimulated Stress Hormone Response in Irritable Bowel Syndrome (IBS) Is Associated With Downregulation of Glucocorticoid Receptor Expression

2015 ◽  
Vol 148 (4) ◽  
pp. S-54-S-55
Author(s):  
Mopelola A. Adeyemo ◽  
Wendy Shih ◽  
Angela P. Presson ◽  
Swapna M. Joshi ◽  
Emeran A. Mayer ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Glucocorticoid Receptor ◽  
Receptor Expression ◽  
Stress Hormone ◽  
Hormone Response ◽  
Irritable Bowel

scholarly journals Increased Kynurenine Production Following Toll-Like Receptor (TLR) Activation: A Novel Role for Tlr8 in Irritable Bowel Syndrome (IBS)

2011 ◽  
Vol 140 (5) ◽  
pp. S-111 ◽  
Author(s):  
Gerard Clarke ◽  
Declan P. McKernan ◽  
Gabor Gaszner ◽  
Eamonn M. Quigley ◽  
John F. Cryan ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Toll Like Receptor ◽  
Irritable Bowel

scholarly journals Altered peripheral toll-like receptor responses in the irritable bowel syndrome

2011 ◽  
Vol 33 (9) ◽  
pp. 1045-1052 ◽  
Author(s):  
D. P. McKernan ◽  
G. Gaszner ◽  
E. M. Quigley ◽  
J. F. Cryan ◽  
T. G. Dinan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Toll Like Receptor ◽  
Irritable Bowel

scholarly journals Toll-Like Receptor mRNA Expression Is Selectively Increased in the Colonic Mucosa of Two Animal Models Relevant to Irritable Bowel Syndrome

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8226 ◽  
Author(s):  
Declan P. McKernan ◽  
Aoife Nolan ◽  
Elizabeth K. Brint ◽  
Siobhain M. O'Mahony ◽  
Niall P. Hyland ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Animal Models ◽  
Mrna Expression ◽  
Colonic Mucosa ◽  
Toll Like Receptor ◽  
Receptor Mrna ◽  
Irritable Bowel
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