scholarly journals Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children

2020 ◽  
Vol 8 ◽  
Author(s):  
Maria D. Ordóñez-Díaz ◽  
Juan L. Pérez-Navero ◽  
Katherine Flores-Rojas ◽  
Josune Olza-Meneses ◽  
Maria C. Muñoz-Villanueva ◽  
...  
Keyword(s):  
Growth Restriction ◽  
Low Grade ◽  
Prepubertal Children ◽  
Extrauterine Growth Restriction

Changes in plasma adipokines in prepubertal children with a history of extrauterine growth restriction

Nutrition ◽  
2013 ◽  
Vol 29 (11-12) ◽  
pp. 1321-1325 ◽  
Author(s):  
María Ortiz-Espejo ◽  
Juan Luís Pérez-Navero ◽  
Josune Olza ◽  
María Carmen Muñoz-Villanueva ◽  
Concepción María Aguilera ◽  
...  
Keyword(s):  
Growth Restriction ◽  
Prepubertal Children ◽  
History Of ◽  
Extrauterine Growth Restriction

scholarly journals Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1201
Author(s):  
María Dolores Ordóñez-Díaz ◽  
Mercedes Gil-Campos ◽  
Katherine Flores-Rojas ◽  
María Carmen Muñoz-Villanueva ◽  
Concepción María Aguilera-García ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Growth Restriction ◽  
Healthy Children ◽  
Anthropometric Parameters ◽  
Metabolic Markers ◽  
Prepubertal Children ◽  
Very Preterm Infants ◽  
History Of ◽  
The Difference ◽  
Extrauterine Growth Restriction

Adipose tissue programming could be developed in very preterm infants with extrauterine growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were measured. Children with a history of EUGR showed lower values of adiponectin (μg/mL) compared with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001. The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9 vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children could lead to a distinctive adipokines profile, likely associated with an early programming of the adipose tissue, and likely to increase the risk of adverse health outcomes later in life.

Nutritional assessment in neonatal and prepubertal children with a history of extrauterine growth restriction

2013 ◽  
Vol 89 (9) ◽  
pp. 763-768 ◽  
Author(s):  
María Ortiz-Espejo ◽  
Juan Luís Pérez-Navero ◽  
María Carmen Muñoz-Villanueva ◽  
Gil-Campos Mercedes
Keyword(s):  
Nutritional Assessment ◽  
Growth Restriction ◽  
Prepubertal Children ◽  
History Of ◽  
Extrauterine Growth Restriction

Alterations in the antioxidant defense system in prepubertal children with a history of extrauterine growth restriction

2013 ◽  
Vol 53 (2) ◽  
pp. 607-615 ◽  
Author(s):  
M. Ortiz-Espejo ◽  
M. Gil-Campos ◽  
M. D. Mesa ◽  
C. E. García-Rodríguez ◽  
M. C. Muñoz-Villanueva ◽  
...  
Keyword(s):  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Growth Restriction ◽  
Defense System ◽  
Prepubertal Children ◽  
History Of ◽  
Extrauterine Growth Restriction

scholarly journals Extrauterine growth restriction among neonates with a birthweight less than 1500 grams

2018 ◽  
Vol 89 (6) ◽  
pp. 325-332 ◽  
Author(s):  
Alejandro Avila-Alvarez ◽  
Alfonso Solar Boga ◽  
Carmen Bermúdez-Hormigo ◽  
Jesús Fuentes Carballal
Keyword(s):  
Growth Restriction ◽  
Extrauterine Growth Restriction

scholarly journals Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children

2018 ◽  
Vol 2 (3) ◽  
pp. 232-239 ◽  
Author(s):  
Henrikki Nordman ◽  
Raimo Voutilainen ◽  
Leena Antikainen ◽  
Jarmo Jääskeläinen
Keyword(s):  
Receptor Antagonist ◽  
Gestational Age ◽  
Standard Deviation Score ◽  
Large For Gestational Age ◽  
Birth Size ◽  
Study Cohort ◽  
Low Grade ◽  
Inverse Association ◽  
Prepubertal Children ◽  
Hs Crp

Abstract Context Birth size has an impact on later cardiometabolic risk that is strongly related to low-grade inflammation. Objective To evaluate plasma interleukin-1 receptor antagonist (IL-1ra) concentrations in relation to birth size and cardiometabolic and inflammatory markers in prepubertal children. Design A cohort study. Anthropometric data were recorded. Fasting blood samples were collected for plasma analyses of IL-1ra, alanine transaminase, total cholesterol, high- and low-density lipoprotein cholesterols, triglyceride, glucose, and serum analyses of 25-hydroxyvitamin D [25(OH)D] and high-sensitivity C-reactive protein (hs-CRP) concentrations. Participants Forty-nine large for gestational age (LGA), 56 appropriate for gestational age, and 23 small for gestational age (SGA) children at 5 to 8 years of age were examined. Main Outcome Measures Differences in IL-1ra concentrations among the birth-size groups and associations between IL-1ra and other metabolic markers were assessed. Results Body mass index (BMI) standard deviation score (SDS)-adjusted plasma IL-1ra concentrations were highest in the SGA- and lowest in the LGA-born children (P = 0.015). Age- and sex-adjusted IL-1ra concentrations had strongest associations with BMI SDS (P &lt; 0.001) and hs-CRP (P &lt; 0.001, also when further adjusted for BMI SDS). Conclusions Prepubertal children born SGA had the highest and those born LGA the lowest IL-1ra concentrations in this study cohort. Most associations found between IL-1ra and the studied metabolic parameters were weight related, but the association with hs-CRP remained strong after adjustment for BMI. It seems that at prepuberty, SGA children have a stronger inflammatory state than LGA children and may thus be at a greater risk for later metabolic disturbances.

Quality Initiative to Reduce Extrauterine Growth Restriction in Very Low Birth Weight Infants

2022 ◽  
Author(s):  
Ramasubbareddy Dhanireddy ◽  
Patricia A. Scott ◽  
Brenda Barker ◽  
Theresa A. Scott
Keyword(s):  
Birth Weight ◽  
Primary Outcome ◽  
Very Low Birth Weight ◽  
Caloric Intake ◽  
Growth Restriction ◽  
Quality Improvement Initiative ◽  
Low Birth Weight Infants ◽  
Process Measures ◽  
Extrauterine Growth Restriction ◽  
Parenteral Protein

BACKGROUND: We report a statewide quality improvement initiative aimed to decrease the incidence of extrauterine growth restriction among very low birth weight infants cared for in Tennessee NICUs. METHODS: The cohort consisted of infants born appropriate for gestational age between May 2016 and December 2018 from 9 NICUs across Tennessee. The infants were 23 to 32 weeks gestation and 500 to 1499 g birth weight. The process measures were the hours of life (HOL) when parenteral protein and intravenous lipid emulsion were initiated, the number of days to first enteral feeding, and attainment of full enteral caloric intake (110–130 kcal/kg per day). The primary outcome was extrauterine growth restriction, defined as weight &lt;10th percentile for weight at 36 weeks postmenstrual age. Statistical process control charts and the Shewhart control rules were used to find special cause variation. RESULTS: Although special cause variation was not indicated in the primary outcome measure, it was indicated for the reduction in specific process measures: HOL when parenteral protein was initiated, HOL when intravenous lipid emulsion was initiated, and the number of days to attainment of full enteral caloric intake (among the hospitals considered regional perinatal centers). CONCLUSIONS: A statewide quality improvement initiative led to earlier initiation of parenteral and enteral nutrition and improved awareness of the importance of postnatal nutrition.

Extrauterine growth restriction was associated with short stature and thinness in very low birthweight infants at around six years of age

2018 ◽  
Vol 108 (1) ◽  
pp. 112-117 ◽  
Author(s):  
Toshimitsu Takayanagi ◽  
Akinori Shichijo ◽  
Masakazu Egashira ◽  
Tomoko Egashira ◽  
Tomoko Mizukami
Keyword(s):  
Short Stature ◽  
Low Birthweight ◽  
Growth Restriction ◽  
Very Low Birthweight ◽  
Very Low Birthweight Infants ◽  
Extrauterine Growth Restriction

Prepubertal Children Exposed to Maternal Gestational Diabetes Have Latent Low-Grade Inflammation

2018 ◽  
Vol 90 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Leena Antikainen ◽  
Jarmo Jääskeläinen ◽  
Henrikki Nordman ◽  
Raimo Voutilainen ◽  
Hanna Huopio
Keyword(s):  
Blood Pressure ◽  
Lipid Metabolism ◽  
Gestational Diabetes ◽  
Low Grade ◽  
Prepubertal Children ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Hs Crp ◽  
Low Grade Inflammation

Background: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children’s height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. Methods: A cohort of 135 prepubertal Caucasian children (age range 4.4–9.7 years) was studied in a controlled cross-sectional study. Seventy-seven children had been exposed to maternal GDM, and 58 children born after a normal pregnancy served as controls. The outcomes were height, weight, BMI, blood pressure, and biochemical markers of glucose and lipid metabolism and inflammation. Results: There were no differences in height, weight, BMI, fasting serum insulin, plasma glucose, lipids, or blood pressure between the study groups. However, high-sensitivity C-reactive protein (hs-CRP) was significantly higher in the GDM group than in the controls (p = 0.001). Conclusions: Higher hs-CRP as a marker of low-grade inflammation was detected in prepubertal children exposed to maternal GDM, but no differences were seen in height, weight, BMI, or markers of glucose and lipid metabolism compared to control children. This finding may reflect an ongoing process of metabolic changes in children born after a GDM pregnancy.

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