Changes in plasma adipokines in prepubertal children with a history of extrauterine growth restriction

Nutrition ◽  
2013 ◽  
Vol 29 (11-12) ◽  
pp. 1321-1325 ◽  
Author(s):  
María Ortiz-Espejo ◽  
Juan Luís Pérez-Navero ◽  
Josune Olza ◽  
María Carmen Muñoz-Villanueva ◽  
Concepción María Aguilera ◽  
...  
Keyword(s):  
Growth Restriction ◽  
Prepubertal Children ◽  
History Of ◽  
Extrauterine Growth Restriction

scholarly journals Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1201
Author(s):  
María Dolores Ordóñez-Díaz ◽  
Mercedes Gil-Campos ◽  
Katherine Flores-Rojas ◽  
María Carmen Muñoz-Villanueva ◽  
Concepción María Aguilera-García ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Growth Restriction ◽  
Healthy Children ◽  
Anthropometric Parameters ◽  
Metabolic Markers ◽  
Prepubertal Children ◽  
Very Preterm Infants ◽  
History Of ◽  
The Difference ◽  
Extrauterine Growth Restriction

Adipose tissue programming could be developed in very preterm infants with extrauterine growth restriction (EUGR), with an adverse impact on long-term metabolic status, as was studied in intrauterine growth restriction patterns. The aim of this cohort study was to evaluate the difference in levels of plasma adipokines in children with a history of EUGR. A total of 211 school age prepubertal children were examined: 38 with a history of prematurity and EUGR (EUGR), 50 with a history of prematurity with adequate growth (PREM), and 123 healthy children born at term. Anthropometric parameters, blood pressure, metabolic markers and adipokines (adiponectin, resistin, leptin) were measured. Children with a history of EUGR showed lower values of adiponectin (μg/mL) compared with the other two groups: (EUGR: 10.6 vs. PREM: 17.7, p < 0.001; vs. CONTROL: 25.7, p = 0.004) and higher levels of resistin (ng/mL) (EUGR: 19.2 vs. PREM: 16.3, p =0.007; vs. CONTROL: 7.1, p < 0.001. The PREM group showed the highest values of leptin (ng/mL), compared with the others: PREM: 4.9 vs. EUGR: 2.1, p = 0.048; vs. CONTROL: 3.2, p = 0.029). In conclusion, EUGR in premature children could lead to a distinctive adipokines profile, likely associated with an early programming of the adipose tissue, and likely to increase the risk of adverse health outcomes later in life.

Nutritional assessment in neonatal and prepubertal children with a history of extrauterine growth restriction

2013 ◽  
Vol 89 (9) ◽  
pp. 763-768 ◽  
Author(s):  
María Ortiz-Espejo ◽  
Juan Luís Pérez-Navero ◽  
María Carmen Muñoz-Villanueva ◽  
Gil-Campos Mercedes
Keyword(s):  
Nutritional Assessment ◽  
Growth Restriction ◽  
Prepubertal Children ◽  
History Of ◽  
Extrauterine Growth Restriction

Alterations in the antioxidant defense system in prepubertal children with a history of extrauterine growth restriction

2013 ◽  
Vol 53 (2) ◽  
pp. 607-615 ◽  
Author(s):  
M. Ortiz-Espejo ◽  
M. Gil-Campos ◽  
M. D. Mesa ◽  
C. E. García-Rodríguez ◽  
M. C. Muñoz-Villanueva ◽  
...  
Keyword(s):  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Growth Restriction ◽  
Defense System ◽  
Prepubertal Children ◽  
History Of ◽  
Extrauterine Growth Restriction

scholarly journals Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children

2020 ◽  
Vol 8 ◽  
Author(s):  
Maria D. Ordóñez-Díaz ◽  
Juan L. Pérez-Navero ◽  
Katherine Flores-Rojas ◽  
Josune Olza-Meneses ◽  
Maria C. Muñoz-Villanueva ◽  
...  
Keyword(s):  
Growth Restriction ◽  
Low Grade ◽  
Prepubertal Children ◽  
Extrauterine Growth Restriction

scholarly journals Impaired Antioxidant Defence Status Is Associated With Metabolic-Inflammatory Risk Factors in Preterm Children With Extrauterine Growth Restriction: The BIORICA Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
María Dolores Ordóñez-Díaz ◽  
Mercedes Gil-Campos ◽  
Katherine Flores-Rojas ◽  
María Carmen Muñoz-Villanueva ◽  
María Dolores Mesa ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Growth Restriction ◽  
The Other ◽  
Antioxidant Defence ◽  
Preterm Children ◽  
Increased Risk ◽  
Antioxidant Defence System ◽  
History Of ◽  
Extrauterine Growth Restriction ◽  
Β Carotene

Introduction: An impaired antioxidant status has been described during foetal growth restriction (FGR). Similarly, the antioxidant defence system can be compromised in preterm children with extrauterine growth restriction (EUGR). The aim of this prospective study was to evaluate the antioxidant status in prepubertal children with a history of prematurity without FGR, with and without EUGR, compared to a healthy group.Methods: In total, 211 children were recruited and classified into three groups: 38 with a history of prematurity and EUGR; 50 with a history of prematurity and adequate extrauterine growth (AEUG); and 123 control children born at term. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were assessed in lysed erythrocytes with spectrophotometric methods. Plasma levels of the antioxidants α-tocopherol, retinol and β-carotene were determined through solvent extraction and ultra-high-pressure liquid chromatography coupled to mass spectrometry.Results: Children with the antecedent of EUGR and prematurity had lower CAT activity than the other two groups and lower GPx activity than the control children. Lower SOD, GPx and GR activities were observed in the AEUG group compared to the controls. However, higher concentrations of α-tocopherol and β-carotene were found in the EUGR group compared to the other groups; retinol levels were also higher in EUGR than in AEUG children. In EUGR and AEUG children, enzymatic antioxidant activities and plasma antioxidants were associated with metabolic syndrome components and pro-inflammatory biomarkers.Conclusions: This study reveals, for the first time, that the EUGR condition and prematurity appear to be linked to an impairment of the antioxidant defence status, which might condition an increased risk of adverse metabolic outcomes later in life.

scholarly journals Prepubertal children with a history of extra-uterine growth restriction exhibit low-grade inflammation

2014 ◽  
Vol 112 (3) ◽  
pp. 338-346 ◽  
Author(s):  
María Ortiz-Espejo ◽  
Juan Luis Pérez-Navero ◽  
Josune Olza-Meneses ◽  
María Carmen Muñoz-Villanueva ◽  
Concepción María Aguilera-García ◽  
...  
Keyword(s):  
Growth Factor ◽  
Reference Group ◽  
Plasma Concentrations ◽  
Growth Restriction ◽  
Inflammatory Biomarkers ◽  
Prepubertal Children ◽  
Tnf Α ◽  
Uterine Growth ◽  
History Of

Intra-uterine growth restriction (IUGR) may induce significant metabolic and inflammatory anomalies, increasing the risk of obesity and CVD later in life. Similarly, alterations in the adipose tissue may lead to metabolic changes in children with a history of extra-uterine growth restriction (EUGR). These mechanisms may induce alterations in immune response during early life. The aim of the present study was to compare pro-inflammatory markers in prepubertal EUGR children with those in a reference population. A total of thirty-eight prepubertal children with a history of EUGR and a reference group including 123 healthy age- and sex-matched children were selected. Perinatal data were examined. In the prepubertal stage, the concentrations of inflammatory biomarkers were measured in both groups. The serum concentrations of C-reactive protein (CRP) and plasma concentrations of hepatocyte growth factor (HGF), IL-6, IL-8, monocyte chemotactic protein type 1 (MCP-1), neural growth factor, TNF-α and plasminogen activator inhibitor type 1 were determined. The plasma concentrations of inflammatory biomarkers CRP, HGF, IL-8, MCP-1 and TNF-α were higher in the EUGR group than in the reference group (P< 0·001). After adjustment for gestational age, birth weight and length, blood pressure values and TNF-α concentrations remained higher in the EUGR group than in the reference group. Therefore, further investigations should be conducted in EUGR children to evaluate the potential negative impact of metabolic, nutritional and pro-inflammatory changes induced by the EUGR condition.

scholarly journals Extrauterine growth restriction among neonates with a birthweight less than 1500 grams

2018 ◽  
Vol 89 (6) ◽  
pp. 325-332 ◽  
Author(s):  
Alejandro Avila-Alvarez ◽  
Alfonso Solar Boga ◽  
Carmen Bermúdez-Hormigo ◽  
Jesús Fuentes Carballal
Keyword(s):  
Growth Restriction ◽  
Extrauterine Growth Restriction

scholarly journals History of periodontal treatment and risk for intrauterine growth restriction (IUGR)

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Cande V. Ananth ◽  
Howard F. Andrews ◽  
Panos N. Papapanou ◽  
Angela M. Ward ◽  
Emilie Bruzelius ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Periodontal Treatment ◽  
Intrauterine Growth ◽  
History Of

Quality Initiative to Reduce Extrauterine Growth Restriction in Very Low Birth Weight Infants

2022 ◽  
Author(s):  
Ramasubbareddy Dhanireddy ◽  
Patricia A. Scott ◽  
Brenda Barker ◽  
Theresa A. Scott
Keyword(s):  
Birth Weight ◽  
Primary Outcome ◽  
Very Low Birth Weight ◽  
Caloric Intake ◽  
Growth Restriction ◽  
Quality Improvement Initiative ◽  
Low Birth Weight Infants ◽  
Process Measures ◽  
Extrauterine Growth Restriction ◽  
Parenteral Protein

BACKGROUND: We report a statewide quality improvement initiative aimed to decrease the incidence of extrauterine growth restriction among very low birth weight infants cared for in Tennessee NICUs. METHODS: The cohort consisted of infants born appropriate for gestational age between May 2016 and December 2018 from 9 NICUs across Tennessee. The infants were 23 to 32 weeks gestation and 500 to 1499 g birth weight. The process measures were the hours of life (HOL) when parenteral protein and intravenous lipid emulsion were initiated, the number of days to first enteral feeding, and attainment of full enteral caloric intake (110–130 kcal/kg per day). The primary outcome was extrauterine growth restriction, defined as weight &lt;10th percentile for weight at 36 weeks postmenstrual age. Statistical process control charts and the Shewhart control rules were used to find special cause variation. RESULTS: Although special cause variation was not indicated in the primary outcome measure, it was indicated for the reduction in specific process measures: HOL when parenteral protein was initiated, HOL when intravenous lipid emulsion was initiated, and the number of days to attainment of full enteral caloric intake (among the hospitals considered regional perinatal centers). CONCLUSIONS: A statewide quality improvement initiative led to earlier initiation of parenteral and enteral nutrition and improved awareness of the importance of postnatal nutrition.

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