scholarly journals Diagnostic Value of Serum Procollagen III N-Terminal Peptide for Liver Fibrosis in Infantile Cholestasis

2020 ◽  
Vol 8 ◽  
Author(s):  
Yingcan Wang ◽  
Weihua Pan ◽  
Dongying Zhao ◽  
Yan Chen ◽  
Xuting Chen ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Diagnostic Value ◽  
Infantile Cholestasis ◽  
Procollagen Iii

APRI, the FIB-4 score, and Forn’s index have noninvasive diagnostic value for liver fibrosis in patients with chronic hepatitis B

2013 ◽  
Vol 25 (9) ◽  
pp. 1076-1081 ◽  
Author(s):  
Fatma Ucar ◽  
Sevilay Sezer ◽  
Zeynep Ginis ◽  
Gulfer Ozturk ◽  
Aynur Albayrak ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Diagnostic Value

Diagnostic accuracy of the Coopscore© to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection

2017 ◽  
Vol 55 (2) ◽  
pp. 236-243 ◽  
Author(s):  
Ludmia Taibi ◽  
Anders Boyd ◽  
Nelly Bosselut ◽  
Julie Bottero ◽  
Jérôme Guéchot ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Diagnostic Value ◽  
Virus Hepatitis ◽  
Significant Fibrosis ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Fibrosis Staging

Background Non-invasive methods for assessing liver fibrosis are increasingly used as an alternative to liver biopsy. Recently, a score-based biochemical blood test (Coopscore©) was developed in a cohort of patients chronically infected with hepatitis C virus, showing higher diagnostic performances than Fibrometer®, Fibrotest®, Hepascore® and Fibroscan™. Here, we assess its performance in patients co-infected with the human immunodeficiency virus and hepatitis B virus. Methods Ninety-seven human immunodeficiency virus/hepatitis B virus co-infected patients with liver biopsies were included from a previously described cohort. Histological fibrosis staging using METAVIR criteria was used as the reference. Coopscore©, Fibrotest®, Fibrometer®, Hepascore® and Zeng score were computed and compared with the Coopscore© using the Obuchowski index and area under the receiving operator characteristic curves. Results The distribution of liver fibrosis levels was as follows: F0–F1 ( n = 42), F2 ( n = 25), F3 ( n = 15) and F4 ( n = 15). The Obuchowski index was higher for Coopscore© (0.774) than Fibrometer® (0.668), Hepascore® (0.690) and Zeng scores (0.704) ( P < 0.05), reflecting a better ability to discriminate between fibrosis stages. Similarly, when predicting significant fibrosis (≥F2), the AUROC was significantly greater for the Coopscore© (0.836) than the Hepascore® (0.727) and Zeng scores (0.746), but not for the Fibrotest® (0.778, P = 0.14) or Fibrometer® (0.790, P = 0.19). The Coopscore© did not show a higher capacity than other scores to predict advanced fibrosis (≥F3) or cirrhosis (F4). Conclusions This study supports the diagnostic value of the Coospcore© in fibrosis staging among human immunodeficiency virus/hepatitis B virus co-infected patients, especially to predict significant fibrosis.

Preventative effects of prostaglandin E1 in combination with iodized olive oil on liver fibrosis after transcatheter arterial chemoembolization in a rabbit model of CCl4-induced liver fibrosis

2015 ◽  
Vol 93 (6) ◽  
pp. 451-457 ◽  
Author(s):  
Shuqiang Jin ◽  
Haili Cao ◽  
Kaibing Wang ◽  
Ying Li ◽  
Bin Bai
Keyword(s):  
Liver Fibrosis ◽  
Olive Oil ◽  
Body Mass ◽  
Prostaglandin E1 ◽  
Transcatheter Arterial Chemoembolization ◽  
Rabbit Model ◽  
Serum Levels ◽  
Group B ◽  
Arterial Chemoembolization ◽  
Procollagen Iii

To explore the preventative effects of prostaglandin E1 (PGE1) on a rabbit model of CCl4-induced liver fibrosis after transcatheter arterial chemoembolization (TACE), we generated a rabbit model of CCl4-induced liver fibrosis by treatment with 40% CCl4 in iodized olive oil for 16 weeks. Body mass and serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP), albumin (ALB), albumin:globulin ratio (A:G), total bilirubin (TBIL), and direct bilirubin (DBIL) were measured. After TACE, the levels of hyaluronic acid (HA), procollagen III (PC III), laminin (LN), and collagen IV (IV-C) were measured, and the severity of liver fibrosis as well as the morphology of liver tissues were determined. Body mass in the model group was significantly decreased from 10 to 16 weeks, and the serum levels of ALT, AST, TP, TBIL, and DBIL levels were significantly increased while the model was being generated; the levels of ALB and A:G were significantly decreased. After TACE, serum levels of HA, PC III, and LN in the group injected with 1.0 mL iodized olive oil (Group B) were higher than in the group that were injected with 1.0 mL iodized olive oil + 0.2 mL PGE1 (Group C), whereas the serum levels of IV-C were lower. The severity of liver fibrosis was ameliorated in Group C. The combination of PGE1 and iodized olive oil prevented the development of liver fibrosis following TACE.

scholarly journals The diagnostic value of non-invasive serum liver fibrosis indices in the prediction of portal hypertension in cirrhotic patients: a cross-sectional study

2020 ◽  
Vol 8 (1) ◽  
pp. 23-23
Author(s):  
Masood Faghih Dinevari ◽  
Mohammad Hossein Somi ◽  
Mohammad Kazem Tarzamni ◽  
Leila Alizadeh ◽  
Samaneh Abbasian ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Fibrosis ◽  
Color Doppler ◽  
Area Under The Curve ◽  
Predictive Marker ◽  
Diagnostic Value ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Non Invasive ◽  
Cirrhotic Patients

Introduction: Considering that portal hypertension is principally caused by hepatic fibrosis, some studies postulated the predictive value of serum liver fibrosis indices in the diagnosis of portal hypertension. In this study we assessed the prognostic value of serum indices in the diagnosis of portal hypertension in cirrhotic patients. Methods: One hundred two cirrhotic patients were selected according to inclusion/exclusion criteria. Cirrhosis and the Child-Pugh score was determined by the gastroenterologist. Portal hypertension was diagnosed by the radiologist using the color Doppler method. The fasting blood sample was drawn and different serum indices were determined. The following indices were calculated: FIB4, Fibroindex, APRI, FORNS, LOK. Results: The patients mean age was 54.39±6.60 years. About 52.94% of the patients were women. The mean liver enzymes level was higher in patients with portal hypertension. In 50.98% of patients, the etiology of cirrhosis was viral hepatitis. Significant differences was observed between the two groups regarding the studied indices (P<0.05). According to the results of the ROC curve, the FORNS index was a better predictive marker of portal hypertension in cirrhotic patients. The maximum AUC (area under the curve) was for the FORNS index. According to the results of diagnostic tests, the FORNS index had adequate sensitivity and specificity in the diagnosis of portal hypertension with the cut-off value of 8.51. Conclusion: The results of the present study showed that the FORNS index is a better predictor of portal hypertension in cirrhotic patients.

scholarly journals The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients

2015 ◽  
Vol 107 ◽  
Author(s):  
Banu Demet Coskun ◽  
Engin Altinkaya ◽  
Eylem Sevinc ◽  
Mustafa Ozen ◽  
Hatice Karaman ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Diagnostic Value

scholarly journals Diagnostic Value of Serum Autotaxin Levels in Liver Fibrosis in Children with Chronic Hepatitis

2018 ◽  
Vol 3 (2) ◽  
pp. 71-78
Author(s):  
M.A. El-Baz ◽  
O.G. Behairy ◽  
A.I. Mansour ◽  
R.A. Elsayed
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Diagnostic Value

scholarly journals Identification and Validation of Novel Serum Autoantibodies Biomarkers for Staging Liver Fibrosis in Patients With Chronic Hepatitis B

2022 ◽  
Vol 8 ◽  
Author(s):  
Saiping Qi ◽  
Jing Li ◽  
Xiaomin He ◽  
Jialing Zhou ◽  
Zhibin Chen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Microarray Analysis ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Diagnostic Methods ◽  
Pre Treatment

Aim: Liver fibrosis monitoring is essential in patients with chronic hepatitis B (CHB). However, less robust, noninvasive diagnostic methods for staging liver fibrosis, other than liver biopsy, are available. Our previous study demonstrated a panel of cellular proteins recognized by autoantibodies that may have potential value in discrimination of CHB and liver cirrhosis. We aim to assess the diagnostic value of these serum autoantibodies for staging liver fibrosis.Methods: Candidate autoantigens were screened and assessed by microarray analysis in 96 healthy controls and 227 CHB patients with pre-treatment biopsy-proven METAVIR fibrosis score, comprising 69, 115, and 43 cases with S0-1, S2-3, and S4 stages, respectively. Autoantibodies with potential diagnostic value for staging liver fibrosis were verified by enzyme-linked immunosorbent assays (ELISA). Receiver operating characteristic curve was conducted to evaluate autoantibody performance.Results: Microarray analysis identified autoantigens CENPF, ACY1, HSPA6, and ENO1 with potential diagnostic value for liver fibrosis staging, among which CENPF and ACY1 were validated using ELISA. CENPF and ACY1 autoantibodies had area under the curve values of 0.746 and 0.685, 58.14 and 74.42% sensitivity, and 88.41 and 60.87% specificity, respectively, for discriminating liver fibrosis stages S4 and S0-1. The prevalence of CENPF and ACY1 autoantibodies was not correlated with age, sex or level of inflammation.Conclusions: Autoimmune responses may be elicited during progression of liver fibrosis, and serum autoantibodies may be a valuable biomarker for staging liver fibrosis deserving of further study.

The Diagnostic Value of Normalized ADC Using Spleen As A Reference Organ In Assessment Of Liver Fibrosis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Omina Ahmed Kamal ◽  
Aya Yassin Ahmed ◽  
Mona Mohamed Ali ◽  
Mai Ahmed Mostafa
Keyword(s):  
Liver Fibrosis ◽  
Sensitivity And Specificity ◽  
Transient Elastography ◽  
Characteristic Curve ◽  
Diagnostic Value ◽  
Control Group ◽  
Group Data ◽  
Significant Difference ◽  
Apparent Diffusion ◽  
Adc Values

Abstract Objectives To investigate the value of liver ADC normalization using spleen as a reference organ in liver fibrosis assessment, in comparison with transient elastography (Fibroscan). Materials and methods A total of 60 participants were included,30 HCV positive patients and 30 in the control group. We calculated mean Spleen apparent diffusion coefficient (ADC), liver mean ADC and normalized liver ADC (defined as the ratio of Liver ADC to spleen ADC) which were compared between cirrhotic patients and the control group. Data was analyzed and ROC was used to evaluate the performance of nADC. Results No significant difference between spleen ADC values of patient group and control group or in-between different fibrosis stages. A significant negative linear correlation between control and patient groups using ADC (r = -0.900; p = 0.0374) or nADC(r=-1:p&lt;0,001).We also found that the mean liver ADC and nADC value in patients with hepatic fibrosis was significantly lower than that of volunteers (1.53 × 10 − 3 mm2/s vs.1.65 × 10 − 3 mm2/s, p = 0.001 &1.). Liver ADC only could distinguish F0 from F4. After analysis with ROC, there was a statistically significant difference between area under the receiver operating characteristic curve (AUC) of normalized liver ADC and ADC for all groups except for F4 stage. nADC AUC was 0.878 for detection of stage ≥ F2 with sensitivity and specificity of 87% & 80% respectively while ADC AUC was 0.548 with sensitivity and specificity of 62 % & 72% respectively(p = 0.021), ≥ F3 AUC of nADC was0.891 with sensitivity and specificity of 88.7 % & 80% respectively while ADC AUC is 0.603 with sensitivity and specificity of 72% & 72% respectively(p = 0.03), and F4 stage nADC AUC was0.879 for with sensitivity and specificity of 90% & 80% respectively ,while ADC AUC was 0.648 with sensitivity and specificity of 80 % & 72% respectively(p = 0.054) Conclusion Normalized liver ADC using the spleen as a reference organ increases the diagnostic performance of MRI in evaluation of liver fibrosis in comparison to ADC alone.

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