scholarly journals Diagnostic Value of Serum Autotaxin Levels in Liver Fibrosis in Children with Chronic Hepatitis

2018 ◽  
Vol 3 (2) ◽  
pp. 71-78
Author(s):  
M.A. El-Baz ◽  
O.G. Behairy ◽  
A.I. Mansour ◽  
R.A. Elsayed
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Diagnostic Value

APRI, the FIB-4 score, and Forn’s index have noninvasive diagnostic value for liver fibrosis in patients with chronic hepatitis B

2013 ◽  
Vol 25 (9) ◽  
pp. 1076-1081 ◽  
Author(s):  
Fatma Ucar ◽  
Sevilay Sezer ◽  
Zeynep Ginis ◽  
Gulfer Ozturk ◽  
Aynur Albayrak ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Diagnostic Value

scholarly journals The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients

2015 ◽  
Vol 107 ◽  
Author(s):  
Banu Demet Coskun ◽  
Engin Altinkaya ◽  
Eylem Sevinc ◽  
Mustafa Ozen ◽  
Hatice Karaman ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Diagnostic Value

scholarly journals Identification and Validation of Novel Serum Autoantibodies Biomarkers for Staging Liver Fibrosis in Patients With Chronic Hepatitis B

2022 ◽  
Vol 8 ◽  
Author(s):  
Saiping Qi ◽  
Jing Li ◽  
Xiaomin He ◽  
Jialing Zhou ◽  
Zhibin Chen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Microarray Analysis ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Diagnostic Methods ◽  
Pre Treatment

Aim: Liver fibrosis monitoring is essential in patients with chronic hepatitis B (CHB). However, less robust, noninvasive diagnostic methods for staging liver fibrosis, other than liver biopsy, are available. Our previous study demonstrated a panel of cellular proteins recognized by autoantibodies that may have potential value in discrimination of CHB and liver cirrhosis. We aim to assess the diagnostic value of these serum autoantibodies for staging liver fibrosis.Methods: Candidate autoantigens were screened and assessed by microarray analysis in 96 healthy controls and 227 CHB patients with pre-treatment biopsy-proven METAVIR fibrosis score, comprising 69, 115, and 43 cases with S0-1, S2-3, and S4 stages, respectively. Autoantibodies with potential diagnostic value for staging liver fibrosis were verified by enzyme-linked immunosorbent assays (ELISA). Receiver operating characteristic curve was conducted to evaluate autoantibody performance.Results: Microarray analysis identified autoantigens CENPF, ACY1, HSPA6, and ENO1 with potential diagnostic value for liver fibrosis staging, among which CENPF and ACY1 were validated using ELISA. CENPF and ACY1 autoantibodies had area under the curve values of 0.746 and 0.685, 58.14 and 74.42% sensitivity, and 88.41 and 60.87% specificity, respectively, for discriminating liver fibrosis stages S4 and S0-1. The prevalence of CENPF and ACY1 autoantibodies was not correlated with age, sex or level of inflammation.Conclusions: Autoimmune responses may be elicited during progression of liver fibrosis, and serum autoantibodies may be a valuable biomarker for staging liver fibrosis deserving of further study.

The diagnostic value of non-invasive tests for the evaluation of liver fibrosis in chronic hepatitis B patients

2013 ◽  
Vol 73 (4) ◽  
pp. 300-308 ◽  
Author(s):  
Serpil Erdogan ◽  
Halef Okan Dogan ◽  
Sevilay Sezer ◽  
Sema Uysal ◽  
Esra Ozhamam ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Diagnostic Value ◽  
Non Invasive

scholarly journals Diagnostic value of fibronectin discriminant score for predicting liver fibrosis stages in chronic hepatitis C virus patients

2013 ◽  
Vol 12 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Abdelfattah M. Attallah ◽  
Sanaa O. Abdallah ◽  
Ahmed A. Attallah ◽  
Mohamed M. Omran ◽  
Khaled Farid ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Diagnostic Value ◽  
Discriminant Score ◽  
Chronic Hepatitis C Virus

scholarly journals Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C

2017 ◽  
Vol 1 ◽  
pp. 28-33
Author(s):  
Katarzyna Kalita ◽  
Krzysztof Filipczak ◽  
Małgorzata Bieńkiewicz ◽  
Wojciech Deroń ◽  
Zbigniew Deroń ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Real Time ◽  
Chronic Hepatitis B ◽  
Diagnostic Value

scholarly journals The Diagnostic value of FibroScan for the degree of liver fibrosis in patients with ALT<2×ULN chronic hepatitis B

2020 ◽  
Vol 7 (1) ◽  
pp. 030-033
Author(s):  
Shi Wenjian ◽  
Che Tuanjie ◽  
Li Chun ◽  
Li Caidong ◽  
Zhang Yan ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Diagnostic Value
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