scholarly journals A Multidisciplinary Intervention in Childhood Obesity Acutely Improves Insulin Resistance and Inflammatory Markers Independent From Body Composition

2020 ◽  
Vol 8 ◽  
Author(s):  
Ernst Mayerhofer ◽  
Franz Ratzinger ◽  
Nina Elvira Kienreich ◽  
Annika Stiel ◽  
Nadine Witzeneder ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Childhood Obesity ◽  
Inflammatory Markers ◽  
Multidisciplinary Intervention

scholarly journals Effects of Jia Wei Dachaihu-Tang on gut microbiota and inflammatory markers in patients with overweight or obesity: study protocol for a randomized, controlled, double-blinded trial

2021 ◽  
Author(s):  
Yang Gao ◽  
Peipei Hong ◽  
Tingting Liao ◽  
Xuke Han ◽  
Shan Zhou ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Gut Microbiota ◽  
Inflammatory Markers ◽  
Resistance Index ◽  
Overweight And Obesity ◽  
Inflammatory Factors ◽  
Sample Collection ◽  
Double Blinded ◽  
Overweight Or Obesity

Abstract Background The increasing number of overweight and obesity has posed an enormous hazard to the health of worldwide people, but the present methods for it still exist a few drawbacks, which implied that new effective treatment is urgently needed. Jia Wei Dachaihu-Tang (JWDT), a Chinese herbal medicine formulation wildly used to remedy obesity in clinical practice, has been confirmed its effectiveness and safety in our previous studies. In the study, the impacts of JWDT on gut microbiota and inflammatory markers in patients with overweight or obesity will be further investigated. Methods/design: This trial will be a randomized, double-blinded, parallel-group, placebo-controlled single-center trial recruiting 60 participants who are 18 to 80 years of age with a body mass index(BMI) ≥ 25 kg/m2. Participants will be enrolled on a random basis and are equally assigned to either Jia Wei Dachaihu-Tang or placebo for 12 weeks. The primary outcome is the change in BMI during this trial. Secondary outcomes contain changes in waist circumference, waist to hip ratio, blood lipid, insulin resistance index (HOMA-IR), body composition, inflammatory factors, gut microbiome, appetite, etc. Blood and fecal sample collection will be conducted at the baseline and after the 12-week intervention. Discussion This study will further testify the therapeutic effect of JWDT in overweight or obesity, and investigate its power on insulin resistance, body composition, gut microbiota, inflammation, appetite, food intake, emotion. Furthermore, investigators attempt to pursue the possible mechanism that JWDT ameliorates overweight and obesity from the perspective of gut microbiota, expecting to provide new targets and directions for the treatment of obesity. Trial registration: The protocol has been registered on the Chinese Clinical Trial Registry (ChiCTR2000040889) on 14 December 2020,http://www.chictr.org.cn/abouten.aspx.

Effect of restoration of thyroid function on body composition, insulin resistance and visfatin concentrations in women with hypo- and hyperthyroidism

2019 ◽  
Author(s):  
Nadia Sawicka-Gutaj ◽  
Ariadna Zybek-Kocik ◽  
Michal Kloska ◽  
Agata Czarnywojtek ◽  
Jerzy Sowiński ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Thyroid Function

scholarly journals PPAR-γ2 Pro12Ala Variant, Insulin Resistance and Plasma Long-chain Polyunsaturated Fatty Acids in Childhood Obesity

2006 ◽  
Vol 60 (4) ◽  
pp. 485-489 ◽  
Author(s):  
Silvia Scaglioni ◽  
Elvira Verduci ◽  
Michela Salvioni ◽  
Maria Luisa Biondi ◽  
Giovanni Radaelli ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Childhood Obesity ◽  
Polyunsaturated Fatty Acids ◽  
Long Chain

scholarly journals QOL-43. ENDOCRINE AND METABOLIC CHANGES IN CHILDREN TREATED FOR MEDULLOBLASTOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii439-iii439
Author(s):  
Alexey Kalinin ◽  
Natalia Strebkova ◽  
Olga Zheludkova
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Impaired Glucose Tolerance ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Hormone Deficiency ◽  
Oral Glucose ◽  
Oral Glucose Tolerance

Abstract We examined 63 patients (40 males/23 females) after complex treatment of medulloblastoma. Patients had a median age (range) of 11.3 (5.5 ÷ 17.9) years. The median time after the end of treatment was 3.7 (1.5 ÷ 11.6) years. Endocrine disorders were detected with the following frequency: growth hormone deficiency - 98.41% (62 of 63 patients), thyroid hormone deficiency – 69.8% (44/63), adrenal hormone deficiency - 17.4% (11/63). Three cases (4.7%) of premature sexual development were also detected. Lipids levels, beta-cell function and insulin resistance (IR) during 2-h oral glucose tolerance test were evaluated. A mono frequent bioelectrical impedanciometer was used to measure body composition. Overweight (SDS BMI> 1) was observed only in 16 patients (3 girls and 13 boys), obesity (SDS BMI> 2) in 1 boy. Dyslipidemia was found in 34 patients (54%). All patients underwent oral glucose tolerance test. Insulin resistance (ISI Matsuda <2.5 and/or HOMA-IR> 3.2) was detected in 7 patients (11/1%), impaired glucose tolerance (120 min glucose ≥7.8 mmol / l) was observed in 2 patients with IR and in 2 patients without IR. At the same time, IR and impaired glucose tolerance were encountered in only 5 children with overweight and no one with obesity. All patients with impaired glucose tolerance had normal values of fasting glucose (4.3 ÷ 5.04 mmol / l) and HbA1c (4.8 ÷ 5.8%). A bioelectrical impedanciometer was used to measure body composition in 49 cases, the percentage of adipose tissue was increased in 14 patients (28%) with normal BMI.

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