scholarly journals Risk Factors for Indeterminate Interferon-Gamma Release Assay for the Diagnosis of Tuberculosis in Children—A Systematic Review and Meta-Analysis

2019 ◽  
Vol 7 ◽  
Author(s):  
Noëmi R. Meier ◽  
Thomas Volken ◽  
Marc Geiger ◽  
Ulrich Heininger ◽  
Marc Tebruegge ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Interferon Gamma ◽  
Meta Analysis ◽  
Interferon Gamma Release Assay ◽  
Release Assay ◽  
Tuberculosis In Children

scholarly journals Interferon-Gamma Release Assay Improves the Diagnosis of Tuberculosis in Children

2009 ◽  
Vol 28 (6) ◽  
pp. 510-514 ◽  
Author(s):  
Leila Bianchi ◽  
Luisa Galli ◽  
Maria Moriondo ◽  
Giuseppina Veneruso ◽  
Laura Becciolini ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Interferon Gamma Release Assay ◽  
Release Assay ◽  
Tuberculosis In Children

scholarly journals Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Claudia Arrieta-Villegas ◽  
Alberto Allepuz ◽  
Miriam Grasa ◽  
Maite Martín ◽  
Zoraida Cervera ◽  
...  
Keyword(s):  
Risk Factors ◽  
Interferon Gamma ◽  
Diagnostic Tests ◽  
Bcg Vaccine ◽  
Interferon Gamma Release Assay ◽  
Risk Of Infection ◽  
Bcg Vaccination ◽  
High Prevalence ◽  
Release Assay

AbstractVaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.

scholarly journals Radiological Signs of Latent Tuberculosis on Chest Radiography: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 6 (7) ◽  
Author(s):  
Jonathan W Uzorka ◽  
Jacco Wallinga ◽  
Lucia J M Kroft ◽  
Tom H M Ottenhoff ◽  
Sandra M Arend
Keyword(s):  
Systematic Review ◽  
Chest Radiography ◽  
Meta Analysis ◽  
Latent Tuberculosis ◽  
Added Value ◽  
Interferon Gamma Release Assay ◽  
Cross Sectional ◽  
Random Effects Models ◽  
Previous Infection ◽  
Release Assay

Abstract Objective Current guidelines recommend screening for latent tuberculosis infection (LTBI) with a tuberculin skin test (TST) or interferon gamma release assay (IGRA), or both. Many also recommend chest radiography (CXR), although its added value is uncertain. This systematic review assessed the prevalence of abnormalities suggestive of LTBI on CXR (LTBI-CXR lesions) and evaluated the strength of the association. Method We searched 4 databases up to September 2017 and systematically reviewed cross-sectional and cohort studies reporting LTBI-CXR lesions in individuals with a positive TST or IGRA, or both, result. Prevalence estimates were pooled using random effects models and odds ratios (ORs) were used to calculate risk estimates. Results In the 26 included studies, the pooled proportion of individuals with LTBI having LTBI-CXR lesions was 0.15 (95% confidence interval [CI], 0.12–0.18]. In 16 studies that reported on individuals with LTBI and uninfected controls, LTBI-CXR lesions were associated with a positive TST result ≥ 5 mm or ≥ 10 mm (OR, 2.45; 95% CI, 1.00–5.99; and OR, 2.06; 95% CI, 1.38–3.09, respectively) and with a positive QuantiFERON result (OR, 1.99; 95% CI, 1.17–3.39) compared to CXR in uninfected controls. Although few studies reported specified lesions, calcified nodules were most frequently reported in individuals with LTBI (proportion, 0.07; 95% CI, 0.02–0.11). Conclusions Lesions on CXR suggestive of previous infection with Mycobacterium tuberculosis were significantly associated with positive tests for LTBI, although the sensitivity was only 15%. This finding may have added value when detection of past LTBI is important but immunodiagnostic tests may be unreliable.

17417 Risk factors and impact of conversion to an indeterminate interferon-gamma release assay result in patients receiving biologics

2020 ◽  
Vol 83 (6) ◽  
pp. AB82
Author(s):  
Urmi Khanna ◽  
Ariana Ellis ◽  
Anokhi Saklecha ◽  
Joshua Gallop ◽  
Abdulaziz Galadari ◽  
...  
Keyword(s):  
Risk Factors ◽  
Interferon Gamma ◽  
Interferon Gamma Release Assay ◽  
Assay Result ◽  
Release Assay
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