scholarly journals True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review

2015 ◽  
Vol 3 ◽  
Author(s):  
Alberto Verrotti ◽  
Laura Penta ◽  
Letizia Zenzeri ◽  
Laura Lucchetti ◽  
Paolo Giovenali ◽  
...  
Keyword(s):  
Literature Review ◽  
Precocious Puberty ◽  
Leydig Cell ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor

scholarly journals Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a 16-Year-Old Single Woman: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed Abu-Zaid ◽  
Ayman Azzam ◽  
Lama Abdulhamid Alghuneim ◽  
Mona Tarek Metawee ◽  
Tarek Amin ◽  
...  
Keyword(s):  
Literature Review ◽  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Single Woman ◽  
History Of ◽  
Poorly Differentiated ◽  
Sex Cord Stromal Tumors

Sertoli-Leydig cell tumor (SLCT) of ovary is an exceedingly unusual neoplasm that belongs to a group of sex cord-stromal tumors of ovary and accounts for less than 0.5% of all primary ovarian neoplasms. Very few case reports have been documented in the literature so far. Herein, we report a case of primary poorly differentiated ovarian Sertoli-Leydig cell tumor (SLCT) involving the left ovary in a 16-year-old single woman who presented with a 3-month history of a pelviabdominal mass, acne, hirsutism, and menstrual irregularities. In addition, a literature review on ovarian SLCTs is provided.

scholarly journals Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review

2014 ◽  
Vol 7 (1) ◽  
Author(s):  
Dalia Moghazy ◽  
Chakradhari Sharan ◽  
Malika Nair ◽  
Cassandra Rackauskas ◽  
Robert Burnette ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Menopausal Woman ◽  
Post Menopausal Woman ◽  
Post Menopausal

scholarly journals Sertoli-Leydig Cell Tumor of the Ovary, a Rare Cause of Precocious Puberty in a 12-Month-Old Infant

2002 ◽  
Vol 87 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Catherine S. Choong ◽  
Peter J. Fuller ◽  
Simon Chu ◽  
Yvette Jeske ◽  
Francis Bowling ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Leydig Cell ◽  
Central Precocious Puberty ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Total Serum ◽  
Surgical Removal ◽  
Mrna Levels ◽  
Lh Receptor ◽  
Early Juvenile Stage

We report a 12-month-old infant who presented with a 4-month history of isosexual precocious puberty secondary to an estrogenizing Sertoli-Leydig cell tumor of the ovary. Total serum immunoreactive inhibin and subunits A and B were markedly elevated before surgical resection and subsequently decreased 7 wk later into the normal prepubertal range. Twenty weeks following surgical removal, the patient presented again with central precocious puberty; inhibin B levels were raised on this occasion, a luteinizing releasing hormone stimulation test confirmed central precocious puberty. This is the youngest reported occurrence of this rare sex cord stromal neoplasm. The prognosis of this extremely rare tumor presenting at this early juvenile stage is uncertain. This report illustrates the usefulness of serum inhibin as a tumor marker during therapeutic suppression with leuprorelin acetate for central precocious puberty. Analysis of genomic and tumor DNA revealed a normal nucleotide sequence for the LH receptor and the Gαs gene. To understand the molecular pathogenesis of this tumor we analyzed mRNA levels for the inhibin A and B subunits, FSH receptor, LH receptor aromatase, steroidogenic factor-1 and the ER β genes. Molecular characterization reveals the presence of genes specific for granulosa and Leydig cells; the relative expression of these genes, in addition to its histologic characteristics, suggests that this tumor may result from a dysdifferentiation of a primordial follicle.

scholarly journals Leydig Cell Tumor in a 53-Year-Old Patient with Gynecomastia and Gynecodynia: A Case Report and Literature Review

2017 ◽  
Vol 10 (10) ◽  
Author(s):  
Piergustavo De Francesco ◽  
Jamil Ghahhari ◽  
Pietro Castellan ◽  
Michele Nicolai ◽  
Graziano De Luca ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor
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