scholarly journals Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a 16-Year-Old Single Woman: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed Abu-Zaid ◽  
Ayman Azzam ◽  
Lama Abdulhamid Alghuneim ◽  
Mona Tarek Metawee ◽  
Tarek Amin ◽  
...  
Keyword(s):  
Literature Review ◽  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Single Woman ◽  
History Of ◽  
Poorly Differentiated ◽  
Sex Cord Stromal Tumors

Sertoli-Leydig cell tumor (SLCT) of ovary is an exceedingly unusual neoplasm that belongs to a group of sex cord-stromal tumors of ovary and accounts for less than 0.5% of all primary ovarian neoplasms. Very few case reports have been documented in the literature so far. Herein, we report a case of primary poorly differentiated ovarian Sertoli-Leydig cell tumor (SLCT) involving the left ovary in a 16-year-old single woman who presented with a 3-month history of a pelviabdominal mass, acne, hirsutism, and menstrual irregularities. In addition, a literature review on ovarian SLCTs is provided.

scholarly journals Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Laura C. Nwogu ◽  
Josh A. Showalter ◽  
Suvra Roy ◽  
Michael T. Deavers ◽  
Bihong Zhao
Keyword(s):  
Leydig Cell ◽  
Stromal Cells ◽  
Ovarian Neoplasms ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Mass ◽  
Immunohistochemical Examination ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors ◽  
Leydig Cell Tumors

Ovarian sex cord-stromal tumors arise from the stromal cells that surround and support the oocytes. Sertoli-Leydig cell tumors belong to this category of ovarian neoplasms. We present the case of a 38-year-old woman who was found to have a right ovarian mass. The mass was resected and diagnosed as Stage I Sertoli-Leydig cell tumor, retiform variant, following histopathologic and immunohistochemical examination. This case is unusual given the rarity of the retiform variant of Sertoli-Leydig cell tumor and the atypically older age of 38 years at presentation.

scholarly journals True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review

2015 ◽  
Vol 3 ◽  
Author(s):  
Alberto Verrotti ◽  
Laura Penta ◽  
Letizia Zenzeri ◽  
Laura Lucchetti ◽  
Paolo Giovenali ◽  
...  
Keyword(s):  
Literature Review ◽  
Precocious Puberty ◽  
Leydig Cell ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor

scholarly journals SUN-011 Beyond PCOS - Ovarian Neoplasms Presenting with Hirsutism and Virilization

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Shourjo Chakravorty ◽  
Brandon Hoard ◽  
Gina Cosentino ◽  
Karen E Friday ◽  
Gabriel Ikponmosa Uwaifo
Keyword(s):  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Total Serum ◽  
Symptom Improvement ◽  
Ovarian Mass ◽  
Multiple Imaging ◽  
History Of ◽  
Androgen Levels

Abstract BACKGROUND: PCOS is the most common cause of hirsutism in women of reproductive age. The presence of virilization in addition to hirsutism should alert to the possibility of less common causes of hyper-androgenization (HA) in this population including otherwise uncommon functional ovarian neoplasms (FON). We present 3 cases of women initially thought to have PCOS in whom virilization was the prime clue to the correct diagnosis of FON. Clinical Case series: Case 1 is a 40yr old woman with obesity and dysmetabolic syndrome referred for hirsutism presumed due to PCOS. She had noted symptoms over 2–3 yrs with amenorrhea and associated infertility. Examination revealed marked hirsutism and virilization with Ferriman-Galleway score (FGS) of 20. Lab tests confirmed marked male range HA. Multiple imaging tests revealed no adrenal or ovarian mass lesions. FDG-PET scan finally revealed a left ovarian focus for which she has left oophorectomy that revealed a 1cm Leydig cell tumor, Her HA resolved post-op and spontaneous periods resumed. Case 2 is a 45yr old woman referred with possible PCOS who had 5 mth history of progressive hirsutism and generalized hypertrichosis, dull lower abdominal pain and amenorrhea. Examination revealed marked hirsutism with generalized hypertrichosis and virilization. FGS was 25 and clitoral index was 935mm2. Lab tests confirmed marked male range HA and abdominopelvic imaging show no adrenal lesions but a 5.2cm left ovarian mass. Left salpingo-oophorectomy revealed a steroid cell tumor and postoperatively her androgen levels normalized. Case 3 is 37 yr old woman with SLE and obesity with prior gastric bypass referred with presumed PCOS but presenting with 1 yr history of progressive hirsutism. She was initially thought to have non classical CAH and treated with oral glucocorticoids with no symptom improvement. Examination revealed marked hirsutism, virilization with elevated FGS and clitoromegaly. Lab tests showed marked male range HA but multiple imaging studies revealed no apparent adrenal or ovarian lesions. Patient had no fertility interests and so had elective total hysterectomy and bilateral salpingo-oophorectomy. Histopathology revealed a 2.5cm left ovarian Leydig cell tumor not apparent at surgery and post op her androgen levels normalized. Conclusion: The distinction between PCOS which is ubiquitous and FON which is rare hinges on careful history and examination. Rapid onset hirsutism with virilization should prompt suspicion of FON. Marked male range HA (total serum testosterone >250ng/dl) is another “red flag” finding. Persistent radiologic search for such lesions should continue as they may not be immediately apparent on routine abdominopelvic imaging.

scholarly journals Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a Postmenopausal Woman: Case Report

2016 ◽  
Vol 26 (2) ◽  
pp. 119-124
Author(s):  
Hamide SAYAR ◽  
Emel CANAZ ◽  
Perihan Özlem DOĞAN ◽  
Gürkan KIRAN ◽  
Derya GÜMÜRDÜLÜ
Keyword(s):  
Case Report ◽  
Postmenopausal Woman ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Poorly Differentiated

scholarly journals Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review

2014 ◽  
Vol 7 (1) ◽  
Author(s):  
Dalia Moghazy ◽  
Chakradhari Sharan ◽  
Malika Nair ◽  
Cassandra Rackauskas ◽  
Robert Burnette ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Menopausal Woman ◽  
Post Menopausal Woman ◽  
Post Menopausal

scholarly journals Primary Mesenteric Sertoli-Leydig Cell Tumor: A Case Report and Review of the Literature

2008 ◽  
Vol 2008 ◽  
pp. 1-3 ◽  
Author(s):  
Amel Trabelsi ◽  
Soumaya Ben Abdelkarim ◽  
Mohamed Hadfi ◽  
Ridha Fatnaci ◽  
Wided Stita ◽  
...  
Keyword(s):  
Case Report ◽  
Leydig Cell ◽  
English Literature ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors

The occurrence of primary sex cord-stromal tumors at extraovarian sites is exceedingly rare. We report a new case of Sertoli-Leydig cell tumor in the mesentery of a 78-year-old woman who presented with occlusive syndrome and reviewed the previously reported cases of extraovarian sex cord-stromal tumors in the English literature.

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