scholarly journals Serotonin Transporter Genotype Linked to Adolescent Substance Use Treatment Outcome through Externalizing Behavior

2014 ◽  
Vol 2 ◽  
Author(s):  
Tammy Chung ◽  
Jack R. Cornelius ◽  
Christopher S. Martin ◽  
Robert Ferrell ◽  
Stephen A. Maisto ◽  
...  
Keyword(s):  
Substance Use ◽  
Treatment Outcome ◽  
Serotonin Transporter ◽  
Externalizing Behavior ◽  
Adolescent Substance Use ◽  
Substance Use Treatment ◽  
Adolescent Substance ◽  
Serotonin Transporter Genotype

scholarly journals The association of prenatal cocaine exposure, externalizing behavior and adolescent substance use

2017 ◽  
Vol 176 ◽  
pp. 33-43 ◽  
Author(s):  
Sonia Minnes ◽  
Meeyoung O. Min ◽  
June-Yung Kim ◽  
Meredith W. Francis ◽  
Adelaide Lang ◽  
...  
Keyword(s):  
Substance Use ◽  
Externalizing Behavior ◽  
Adolescent Substance Use ◽  
Cocaine Exposure ◽  
Prenatal Cocaine Exposure ◽  
Adolescent Substance ◽  
Prenatal Cocaine

scholarly journals Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior

2007 ◽  
Vol 38 (9) ◽  
pp. 1341-1350 ◽  
Author(s):  
L. N. Legrand ◽  
M. Keyes ◽  
M. McGue ◽  
W. G. Iacono ◽  
R. F. Krueger
Keyword(s):  
Substance Use ◽  
Environmental Factors ◽  
Externalizing Behavior ◽  
Genetic Influence ◽  
Adolescent Substance Use ◽  
Environment Interaction ◽  
Adolescent Substance ◽  
Oppositional Defiant ◽  
Rural Environments ◽  
Rule Breaking

BackgroundThere is increasing evidence that certain environmental factors can modify genetic effects. This is an important area of investigation as such work will help to guide the development of new intervention programs. In this paper, we address whether rural environments moderate the genetic influence on adolescent substance use and rule-breaking behavior (i.e. externalizing psychopathology).MethodOver 1200 Minnesotan 17-year-old twins were classified as either urban or rural. Externalizing behavior was operationalized as the use and abuse of alcohol and drugs along with symptoms of conduct, oppositional defiant, and antisocial personality disorders. Biometric factor modeling estimated whether the relative contribution of genetic and shared environmental factors varied from urban to rural settings.ResultsResidency effects reached statistical significance in the male sample only. In urban environments, externalizing behavior was substantially influenced by genetic factors, but in rural environments, shared environmental factors became more influential. This was apparent at both the individual-variable and factor levels.ConclusionsThese findings suggest a gene–environment interaction in the development of male adolescents' problem behaviors, including substance use. The results fit within an expanding literature demonstrating both the contextual nature of the heritability statistic and how certain environments may constrain the expression of genetic tendencies.

scholarly journals Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use.

2016 ◽  
Vol 125 (4) ◽  
pp. 565-575 ◽  
Author(s):  
Elisa M. Trucco ◽  
Brian M. Hicks ◽  
Sandra Villafuerte ◽  
Joel T. Nigg ◽  
Margit Burmeister ◽  
...  
Keyword(s):  
Substance Use ◽  
Genetic Risk ◽  
Externalizing Behavior ◽  
Adolescent Substance Use ◽  
Adolescent Substance
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