scholarly journals Assessment of Liver Function for Evaluation of Long-Term Outcomes of Intrahepatic Cholangiocarcinoma: A Multi-Institutional Analysis of 620 Patients

2020 ◽  
Vol 10 ◽  
Author(s):  
Hui Li ◽  
Jiaxin Li ◽  
Jinju Wang ◽  
Hailing Liu ◽  
Bole Cai ◽  
...  
Keyword(s):  
Liver Function ◽  
Intrahepatic Cholangiocarcinoma ◽  
Institutional Analysis ◽  
Long Term Outcomes

scholarly journals Abnormal Liver Function Tests and Long-Term Outcomes in Patients Discharged after Acute Heart Failure

2021 ◽  
Vol 10 (8) ◽  
pp. 1730
Author(s):  
Hiroshi Miyama ◽  
Yasuyuki Shiraishi ◽  
Shun Kohsaka ◽  
Ayumi Goda ◽  
Yosuke Nishihata ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Adverse Outcomes ◽  
Long Term Outcomes ◽  
Function Tests ◽  
Parameter Values

Abnormal liver function tests (LFTs) are known to be associated with impaired clinical outcomes in heart failure (HF) patients. However, this implication varies with each single LFT panel. We aim to evaluate the long-term outcomes of acute HF (AHF) patients by assessing multiple LFT panels in combination. From a prospective multicenter registry in Japan, 1158 AHF patients who were successfully discharged were analyzed (mean age, 73.9 ± 13.5 years; men, 58%). LFTs (i.e., total bilirubin, aspartate aminotransferase or alanine aminotransferase, and alkaline phosphatase) at discharge were assessed; borderline and abnormal LFTs were defined as 1 and ≥2 parameter values above the normal range, respectively. The primary endpoint was composite of all-cause death or HF readmission. At the time of discharge, 28.7% and 8.6% of patients showed borderline and abnormal LFTs, respectively. There were 196 (16.9%) deaths and 298 (25.7%) HF readmissions during a median 12.4-month follow-up period. The abnormal LFTs group had a significantly higher risk of experiencing the composite outcome (adjusted hazard ratio: 1.51, 95% confidence interval: 1.08–2.12, p = 0.017), whereas the borderline LFTs group was not associated with higher risk of adverse events when referenced to the normal LFTs group. Among AHF patients, the combined elevation of ≥2 LFT panels at discharge was associated with long-term adverse outcomes.

scholarly journals Preoperative Risk Score and Prediction of Long-Term Outcomes after Hepatectomy for Intrahepatic Cholangiocarcinoma

2018 ◽  
Vol 226 (4) ◽  
pp. 393-403 ◽  
Author(s):  
Kazunari Sasaki ◽  
Georgios A. Margonis ◽  
Nikolaos Andreatos ◽  
Fabio Bagante ◽  
Matthew Weiss ◽  
...  
Keyword(s):  
Risk Score ◽  
Intrahepatic Cholangiocarcinoma ◽  
Long Term Outcomes ◽  
Preoperative Risk

scholarly journals Long-term outcomes of patients with intraductal growth sub-type of intrahepatic cholangiocarcinoma

HPB ◽  
2018 ◽  
Vol 20 (12) ◽  
pp. 1189-1197 ◽  
Author(s):  
Fabio Bagante ◽  
Matthew Weiss ◽  
Sorin Alexandrescu ◽  
Hugo P. Marques ◽  
Luca Aldrighetti ◽  
...  
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Long Term Outcomes ◽  
Intraductal Growth
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