scholarly journals The Effect of Intravenous Vitamin C on Cancer- and Chemotherapy-Related Fatigue and Quality of Life

2014 ◽  
Vol 4 ◽  
Author(s):  
Anitra C. Carr ◽  
Margreet C. M. Vissers ◽  
John S. Cook
Keyword(s):  
Quality Of Life ◽  
Vitamin C ◽  
Intravenous Vitamin

High-dose intravenous vitamin C improves quality of life in cancer patients

2012 ◽  
Vol 1 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Hidenori Takahashi ◽  
Haruyoshi Mizuno ◽  
Atsuo Yanagisawa
Keyword(s):  
Quality Of Life ◽  
Vitamin C ◽  
Cancer Patients ◽  
High Dose ◽  
Intravenous Vitamin

scholarly journals The Use of Intravenous Vitamin C as a Supportive Therapy for a Patient with Glioblastoma Multiforme

Antioxidants ◽  
2018 ◽  
Vol 7 (9) ◽  
pp. 115 ◽  
Author(s):  
Nicola Baillie ◽  
Anitra Carr ◽  
Selene Peng
Keyword(s):  
Quality Of Life ◽  
Glioblastoma Multiforme ◽  
Vitamin C ◽  
Supportive Therapy ◽  
European Organization ◽  
Eortc Qlq C30 ◽  
Mri Scans ◽  
Intravenous Vitamin ◽  
Eortc Qlq

Glioblastoma multiforme is a high grade malignant brain tumour with a poor prognosis. Here we report the case of a woman with glioblastoma who lived for over four years from diagnosis (median survival 12 months and 2% survival for three years), experiencing good quality of life for most of that time. She underwent initial debulking craniotomy, radiotherapy and chemotherapy, as well as having intravenous vitamin C infusions 2–3 times weekly over the four years from diagnosis. Her progress was monitored by blood tests, regular computerised tomography (CT) and magnetic resonance imaging (MRI) scans, clinical reviews and European Organization for the Research and Treatment of Cancer quality of life questionnaires (EORTC QLQ C30). Our case report highlights the benefits of intravenous vitamin C as a supportive therapy for patients with glioblastoma.

scholarly journals Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3142
Author(s):  
Julie C Lim ◽  
Mariana Caballero Arredondo ◽  
Andrea J. Braakhuis ◽  
Paul J. Donaldson
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Vitamin C ◽  
Oxidative Damage ◽  
Cataract Surgery ◽  
Future Studies ◽  
The World ◽  
Diabetic Population ◽  
Lens Physiology

Cataracts or clouding of the lens is the leading cause of blindness in the world. Age and diabetes are major risk factors, and with an increasing aging and diabetic population, the burden of cataracts will grow. Cataract surgery is an effective way to restore vision; however, alternatives to cataract surgery are required to reduce the looming cataract epidemic. Since it is well established that oxidative damage plays a major role in the etiology of cataracts, antioxidants have been promoted as therapies to delay and/or prevent cataracts. However, many antioxidant interventions including vitamin C have produced mixed results as anti-cataract therapies. Progress has been made towards our understanding of lens physiology and the mechanisms involved in the delivery and uptake of antioxidants to the lens which may guide future studies aimed at addressing some of the inconsistencies seen in previous animal and human studies. Of interest is the potential for vitamin C based supplements in delaying the onset of cataracts post vitrectomy which occurs in up to 80% of patients within two years. These targeted approaches are required to reduce the burden of cataract on hospitals and improve the quality of life of our aging and diabetic population.

scholarly journals Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Quality of Life of Patient with History of Relapsed Acute Myeloid Leukaemia

Antioxidants ◽  
2018 ◽  
Vol 7 (7) ◽  
pp. 92 ◽  
Author(s):  
Mike Foster ◽  
Anitra Carr ◽  
Alina Antony ◽  
Selene Peng ◽  
Mike Fitzpatrick
Keyword(s):  
Quality Of Life ◽  
Vitamin C ◽  
Health Related Quality ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Related Quality ◽  
Health Related ◽  
History Of ◽  
Acute Myeloid

A 52-year-old female presented to Integrated Health Options Clinic in October 2014 with a history of relapsed acute myeloid leukaemia (AML, diagnosed in 2009 and relapsed in 2014). Intravenous(IV) vitamin C therapy was initiated (in 2014) following completion of chemotherapy as an alternative to haematopoietic stem cell transplantation. IV vitamin C was administered twice weekly at a dose of 70 g/infusion. Within 4 weeks of initiation of IV vitamin C therapy, there was a dramatic improvement in the patient’s blood indices with platelet cell counts increasing from 25 × 109/L to 196 × 109/L and white blood cell counts increasing from 0.29 × 109/L to 4.0 × 109/L, with further improvements observed over the next 18 months. Furthermore, there was a clear and sustained improvement in the patient’s health-related quality of life scores assessed using a validated questionnaire. She has remained healthy and in complete remission until the present day. This case study highlights the benefits of IV vitamin C as a supportive therapy for previously relapsed AML.

scholarly journals Vitamin C can reduce mortality in sepsis: a systematic review and meta-analysis of animal and human evidence

2020 ◽  
Author(s):  
Cong-Cong Zhao ◽  
Li-Nan Han ◽  
Gui-Jun Zhu ◽  
Zhi-Qiang Li ◽  
Zhen-Jie Hu
Keyword(s):  
Systematic Review ◽  
Mean Arterial Pressure ◽  
Vitamin C ◽  
Animal Studies ◽  
Meta Analysis ◽  
Capillary Density ◽  
Human Studies ◽  
Pooled Data ◽  
Intravenous Vitamin

Abstract Background: The effect of vitamin C on outcomes in sepsis is unclear. This systematic review and meta-analysis included animal and human studies to evaluate the value of intravenous vitamin C as a monotherapy in sepsis. Methods: We searched MEDLINE via PubMed, EMBASE, CENTRAL and CBM for animal studies, randomized controlled trials (RCTs), and quasi-RCTs dated up to August 10, 2020. The included studies compared the effect of intravenous vitamin C and control on outcomes in sepsis. No language restrictions were applied. Two authors independently assessed the eligibility and quality of the trials and extracted data. Results: A total of 7 animal studies and 5 RCTs were included. Four animal studies (n=176) and all 5 RCTs (n=472) reported mortality, the primary outcome of this meta-analysis. The mortality of the vitamin C group was lower than that of the control group (odds ratio (OR) 0.22, 95% CI 0.06 to 0.81, P = 0.02; I2 =60% in animal studies, and OR 0.48, 95% CI 0.33 to 0.71, P < 0.001; I2 =0% in human studies). The GRADE assessment showed that the outcome was downgraded from high- to moderate-quality evidence due to imprecision. With regard to the secondary outcomes, the pooled data from animal studies showed that vitamin C had a beneficial effect on mean arterial pressure (std. mean difference (SMD) 1.36, 95% CI 0.32 to 2.41, P = 0.01; I2 =78%) and capillary density (SMD 1.97, 95% CI 0.89 to 3.04, P=0.69; I2 =0%) but had no effect on the level of lactate. The pooled data from human studies showed that vitamin C was associated with a reduction in vasopressor duration (MD -18.85, 95% CI -24.61 to -11.55, P < 0.001; I2 =0%) but could not shorten the length of ICU stay or duration of mechanical ventilation. No adverse effects were reported.Conclusions: Evidence from animal and human studies suggests that intravenous vitamin C monotherapy can reduce mortality in sepsis, with a moderate quality of evidence. We also found that vitamin C had a beneficial effect on mean arterial pressure, capillary density, and reduction of vasopressor duration in sepsis.

scholarly journals Effect of intravenous vitamin C supplementation on the quality of sleep, itching and restless leg syndrome in patients undergoing hemodialysis; A double-blind randomized clinical trial

2018 ◽  
Vol 7 (2) ◽  
pp. 131-136 ◽  
Author(s):  
Shahdak Dadashpour ◽  
Minoo Sadat Hajmiri ◽  
Daem Roshani
Keyword(s):  
Clinical Trial ◽  
Vitamin C ◽  
Sleep Quality ◽  
Intervention Group ◽  
Hemodialysis Patients ◽  
Restless Leg Syndrome ◽  
Quality Of Sleep ◽  
Double Blind ◽  
Intravenous Vitamin

Introduction: Poor sleep quality is common among hemodialysis patients and can potentially predict morbidity, mortality and quality of life in these patients. On the other hand, hemodialysis patients are encountered with vitamin C deficiency. Objectives: The purpose of this study was to determine the effect of intravenous vitamin C on sleep quality, itching and restless leg syndrome in hemodialysis patients. Patients and Methods: In this double-blind randomized clinical trial, 90 qualified hemodialysis patients were gone under investigation in Sanandaj in 2016. Patients randomly allocated in two equal intervention and control groups. The main measured outcome was the Pittsburg Sleep Quality Index (PSQI) which consists of seven components. At the end of each hemodialysis session, the intervention group received vitamin C vial (500 mg/5 cc) intravenously, three times a week for 8 weeks and the control group received normal saline as placebo in the same way. Data were collected at pretreatment and after 2 months of treatment. Additionally raises questions related to restless leg syndrome and was assessed by VAS scale for determining the incidence of pruritus. Data were analyzed by independent t test, paired t test, Wilcoxon and chi-square tests. Results: Around 52.2% of subjects were female and 47.8% were male and most of them were in the age group above 50 years old. Results showed a notable difference in the value of itching and restless leg syndrome between the two groups as these values decreased significantly in the intervention group (P=0.0001). There was also a great difference in the quality of sleep disorder in subjective sleep quality, sleep latency and daily function between the two groups and those disorders was significantly lower in the intervention group (P=0.0001). Conclusion: This study showed that intravenous vitamin C can effectively improve sleep quality, itching and restless legs syndrome in hemodialysis patients.

scholarly journals Correlation between serum vitamin C level and COPD assessment test score in chronic obstructive pulmonary disease patients

2020 ◽  
Vol 4 (1) ◽  
pp. 35
Author(s):  
Cipuk Muhaswitri ◽  
Drupadi Dillon ◽  
Jamal Zaini
Keyword(s):  
Quality Of Life ◽  
Lung Function ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Standard Test ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Copd Assessment Test

Background: COPD is a disease due to oxidative stress causing low pulmonary function, resulting in low quality of life. A standard test to measure the quality of life in COPD is COPD Assessment Test (CAT). Vitamin C as antioxidant is widely available in the pulmonary epithelial fluid.  This study aimed to investigate the correlation between serum vitamin C level and CAT score in COPD.Methods: This cross-sectional study was conducted at Persahabatan Hospital, East Jakarta, involving 47 subjects using consecutive sampling method. Interview was used to assess subjects’ characteristics and vitamin C intake using semi-quantitative FFQ. Clinical classification, lung function, comorbidity, and CAT scores were gathered from medical records or interview. BMI was used to determine nutritional status, while vitamin C serum level was assessed using spectrophotometry. Results and conclusions: All subjects were male, mean age was 66.6 years, mostly ex-heavy  smokers, with decreased lung function, and 25% were undernourished. Vitamin C intake was sufficient, but low in serum vitamin C level and CAT score.There was no correlation between serum vitamin C level and CAT score.

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