scholarly journals Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation

2020 ◽  
Vol 14 ◽  
Author(s):  
Stephano J. Chang ◽  
Iahn Cajigas ◽  
Ioan Opris ◽  
James D. Guest ◽  
Brian R. Noga
Keyword(s):  
Cuneiform Nucleus

Hemodynamic responses and c-Fos changes associated with hypotensive hemorrhage: standardizing a protocol for severe hemorrhage in conscious rats

2007 ◽  
Vol 292 (5) ◽  
pp. R1862-R1871 ◽  
Author(s):  
Joslyn Ahlgren ◽  
Karen Porter ◽  
Linda F. Hayward
Keyword(s):  
Potential Role ◽  
Cardiovascular Response ◽  
Brain Regions ◽  
Total Blood Volume ◽  
Total Blood ◽  
Conscious Rats ◽  
Cuneiform Nucleus ◽  
Severe Hemorrhage ◽  
Lateral Nucleus

The central mechanisms underlying the transition from compensation to decompensation during severe hemorrhage (HEM) are poorly understood. Furthermore, a lack of consistency in HEM protocols exists in the current literature. This study assessed the cardiovascular response and Fos-like immunoreactivity (FLI) in specific brain regions following severe HEM at three rates (2, 1, or 0.5 ml·kg−1·min−1) in conscious rats. Heart rate (HR) and arterial pressure were recorded during the withdrawal of 30% of total blood volume (TBV). Data from animals hemorrhaged at the fast (F-HEM, n = 6), intermediate (I-HEM, n = 7), or slow (S-HEM, n = 7) rates were compared with saline (SAL, n = 5) and hypotensive (hydrazaline-induced, HYDRAZ, n = 5) controls. All HEM rates produced similar degrees of hypotension at the time of 30% TBV withdrawal. All HEM rates also produced bradycardia, but the change in HR was only significant in the F-HEM and I-HEM groups. Associated with I-HEM and F-HEM, but not HYDRAZ treatment were significant increases in FLI in the caudal ventrolateral periaqueductal gray (PAG), the central lateral nucleus of the rostral parabrachial nucleus, and locus coeruleus compared with SAL treatment. I-HEM also induced significant increases in FLI in the dorsomedial PAG, A7 region, and the cuneiform nucleus compared with SAL. S-HEM did not induce any significant change in FLI. Our results suggest that HEM at a rate of 1 ml·kg−1·min−1 may be most useful for investigating the potential role of the rostral brainstem regions in mediating hemorrhagic decompensation in conscious rats.

scholarly journals Brain circuits mediating baroreflex bradycardia inhibition in rats: an anatomical and functional link between the cuneiform nucleus and the periaqueductal grey

2011 ◽  
Vol 589 (8) ◽  
pp. 2079-2091 ◽  
Author(s):  
Florence Netzer ◽  
Jean-François Bernard ◽  
Anthony J. M. Verberne ◽  
Michel Hamon ◽  
Françoise Camus ◽  
...  
Keyword(s):  
Functional Link ◽  
Periaqueductal Grey ◽  
Brain Circuits ◽  
Cuneiform Nucleus
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