Large-Scale Network Analysis of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury: A Comparative Study

2017 ◽  
Vol 7 (7) ◽  
pp. 413-423 ◽  
Author(s):  
Mayank Kaushal ◽  
Akinwunmi Oni-Orisan ◽  
Gang Chen ◽  
Wenjun Li ◽  
Jack Leschke ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Connectivity ◽  
Network Analysis ◽  
Resting State ◽  
Large Scale ◽  
Resting State Functional Connectivity ◽  
Large Scale Network ◽  
Cord Injury ◽  
Scale Network

scholarly journals Resting-state functional connectivity and quantitation of glutamate and GABA of the PCC/precuneus by magnetic resonance spectroscopy at 7T in healthy individuals

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244491
Author(s):  
Ofer M. Gonen ◽  
Bradford A. Moffat ◽  
Patrick Kwan ◽  
Terence J. O’Brien ◽  
Patricia M. Desmond ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Magnetic Resonance Spectroscopy ◽  
Large Scale ◽  
Resonance Spectroscopy ◽  
Resting State Functional Connectivity ◽  
Disease States ◽  
Large Scale Network ◽  
Age Related ◽  
Scale Network

The default mode network (DMN) is the main large-scale network of the resting brain and the PCC/precuneus is a major hub of this network. Glutamate and GABA (γ-amino butyric acid) are the main excitatory and inhibitory neurotransmitters in the CNS, respectively. We studied glutamate and GABA concentrations in the PCC/precuneus via magnetic resonance spectroscopy (MRS) at 7T in relation to age and correlated them with functional connectivity between this region and other DMN nodes in ten healthy right-handed volunteers ranging in age between 23–68 years. Mean functional connectivity of the PCC/precuneus to the other DMN nodes and the glutamate/GABA ratio significantly correlated with age (r = 0.802, p = 0.005 and r = 0.793, p = 0.006, respectively) but not with each other. Glutamate and GABA alone did not significantly correlate with age nor with functional connectivity within the DMN. The glutamate/GABA ratio and functional connectivity of the PCC/precuneus are, therefore, independent age-related biomarkers of the DMN and may be combined in a multimodal pipeline to study DMN alterations in various disease states.

Resting-State Functional Connectivity of the Thalamus in Complete Spinal Cord Injury

2020 ◽  
Vol 34 (2) ◽  
pp. 122-133
Author(s):  
Keerthana Deepti Karunakaran ◽  
Rui Yuan ◽  
Jie He ◽  
Jian Zhao ◽  
Jian-Ling Cui ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Connectivity ◽  
Resting State ◽  
Functional Organization ◽  
Superior Temporal Gyrus ◽  
Anterior Cingulate ◽  
Connectivity Analysis ◽  
Cord Injury ◽  
Ventrolateral Nucleus

Background. Neuroimaging studies of spinal cord injury (SCI) have mostly examined the functional organization of the cortex, with only limited focus on the subcortical substrates of the injury. However, thalamus is an important modulator and sensory relay that requires investigation at a subnuclei level to gain insight into the neuroplasticity following SCI. Objective. To use resting-state functional magnetic resonance imaging to examine the functional connectivity (FC) of thalamic subnuclei in complete SCI patients. Methods. A seed-based connectivity analysis was applied for 3 thalamic subnuclei: pulvinar, mediodorsal, and ventrolateral nucleus in each hemisphere. A nonparametric 2-sample t test with permutations was applied for each of the 6 thalamic seeds to compute FC differences between 22 healthy controls and 19 complete SCI patients with paraplegia. Results. Connectivity analysis showed a decrease in the FC of the bilateral mediodorsal nucleus with right superior temporal gyrus and anterior cingulate cortex in the SCI group. Similarly, the left ventrolateral nucleus exhibited decreased FC with left superior temporal gyrus in SCI group. In contrast, left pulvinar nucleus demonstrated an increase in FC with left inferior frontal gyrus and left inferior parietal lobule in SCI group. Our findings also indicate a negative relationship between postinjury durations and thalamic FC to regions of sensorimotor and visual cortices, where longer postinjury durations (~12 months) is associated with higher negative connectivity between these regions. Conclusion. This study provides evidence for reorganization in the thalamocortical connections known to be involved in multisensory integration and affective processing, with possible implications in the generation of sensory abnormalities after SCI.

scholarly journals Networks of worry—towards a connectivity-based signature of late-life worry using higher criticism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andrew R. Gerlach ◽  
Helmet T. Karim ◽  
Joseph Kazan ◽  
Howard J. Aizenstein ◽  
Robert T. Krafty ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Resting State ◽  
Large Scale ◽  
Resting State Fmri ◽  
Anterior Cingulate ◽  
Resting State Functional Connectivity ◽  
Targeted Interventions ◽  
Higher Criticism ◽  
Large Scale Network

AbstractSevere worry is a complex transdiagnostic phenotype independently associated with increased morbidity, including cognitive impairment and cardiovascular diseases. We investigated the neurobiological basis of worry in older adults by analyzing resting state fMRI using a large-scale network-based approach. We collected resting fMRI on 77 participants (>50 years old) with varying worry severity. We computed region-wise connectivity across the default mode network (DMN), anterior salience network, and left executive control network. All 22,366 correlations were regressed on worry severity and adjusted for age, sex, race, education, disease burden, depression, anxiety, rumination, and neuroticism. We employed higher criticism, a second-level method of significance testing for rare and weak features, to reveal the functional connectivity patterns associated with worry. The analysis suggests that worry has a complex, yet distinct signature associated with resting state functional connectivity. Intra-connectivities and inter-connectivities of the DMN comprise the dominant contribution. The anterior cingulate, temporal lobe, and thalamus are heavily represented with overwhelmingly negative association with worry. The prefrontal regions are also strongly represented with a mix of positive and negative associations with worry. Identifying the most salient connections may be useful for targeted interventions for reducing morbidity associated with severe worry in older adults.

Large-Scale Network Analysis for Online Social Brand Advertising

MIS Quarterly ◽  
2016 ◽  
Vol 40 (4) ◽  
pp. 849-868 ◽  
Author(s):  
Kunpeng Zhang ◽  
◽  
Siddhartha Bhattacharyya ◽  
Sudha Ram ◽  
◽  
...  
Keyword(s):  
Network Analysis ◽  
Large Scale ◽  
Large Scale Network ◽  
Brand Advertising ◽  
Scale Network

Alterations of resting-state regional and network-level neural function after acute spinal cord injury

Neuroscience ◽  
2014 ◽  
Vol 277 ◽  
pp. 446-454 ◽  
Author(s):  
J.-M. Hou ◽  
T.-S. Sun ◽  
Z.-M. Xiang ◽  
J.-Z. Zhang ◽  
Z.-C. Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Resting State ◽  
Acute Spinal Cord Injury ◽  
Neural Function ◽  
Cord Injury ◽  
State Regional

scholarly journals Functional Brain Connectivity during Multiple Motor Imagery Tasks in Spinal Cord Injury

2018 ◽  
Vol 2018 ◽  
pp. 1-20 ◽  
Author(s):  
Alkinoos Athanasiou ◽  
Nikos Terzopoulos ◽  
Niki Pandria ◽  
Ioannis Xygonakis ◽  
Nicolas Foroglou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Connectivity ◽  
Motor Imagery ◽  
Healthy Subjects ◽  
Brain Connectivity ◽  
Descending Pathways ◽  
Brain Organization ◽  
Sensorimotor Network ◽  
Cord Injury

Reciprocal communication of the central and peripheral nervous systems is compromised during spinal cord injury due to neurotrauma of ascending and descending pathways. Changes in brain organization after spinal cord injury have been associated with differences in prognosis. Changes in functional connectivity may also serve as injury biomarkers. Most studies on functional connectivity have focused on chronic complete injury or resting-state condition. In our study, ten right-handed patients with incomplete spinal cord injury and ten age- and gender-matched healthy controls performed multiple visual motor imagery tasks of upper extremities and walking under high-resolution electroencephalography recording. Directed transfer function was used to study connectivity at the cortical source space between sensorimotor nodes. Chronic disruption of reciprocal communication in incomplete injury could result in permanent significant decrease of connectivity in a subset of the sensorimotor network, regardless of positive or negative neurological outcome. Cingulate motor areas consistently contributed the larger outflow (right) and received the higher inflow (left) among all nodes, across all motor imagery categories, in both groups. Injured subjects had higher outflow from left cingulate than healthy subjects and higher inflow in right cingulate than healthy subjects. Alpha networks were less dense, showing less integration and more segregation than beta networks. Spinal cord injury patients showed signs of increased local processing as adaptive mechanism. This trial is registered with NCT02443558.

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