scholarly journals Modulation of Purkinje cell complex spike waveform by synchrony levels in the olivocerebellar system

2014 ◽  
Vol 8 ◽  
Author(s):  
Eric J. Lang ◽  
Tianyu Tang ◽  
Colleen Y. Suh ◽  
Jianqiang Xiao ◽  
Yuriy Kotsurovskyy ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Cell Complex ◽  
Complex Spike

scholarly journals Patterns of Spontaneous Purkinje Cell Complex Spike Activity in the Awake Rat

1999 ◽  
Vol 19 (7) ◽  
pp. 2728-2739 ◽  
Author(s):  
Eric J. Lang ◽  
Izumi Sugihara ◽  
John P. Welsh ◽  
Rodolfo Llinás
Keyword(s):  
Purkinje Cell ◽  
Spike Activity ◽  
Cell Complex ◽  
Complex Spike ◽  
Awake Rat

Developmental Changes in Evoked Purkinje Cell Complex Spike Responses

2003 ◽  
Vol 90 (4) ◽  
pp. 2349-2357 ◽  
Author(s):  
Daniel A. Nicholson ◽  
John H. Freeman
Keyword(s):  
Motor Learning ◽  
Purkinje Cell ◽  
Inferior Olive ◽  
Cell Complex ◽  
Climbing Fibers ◽  
Somatosensory Stimulation ◽  
Complex Spike ◽  
Long Latency ◽  
Inhibitory Feedback ◽  
Complex Spikes

The development of synaptic interconnections between the cerebellum and inferior olive, the sole source of climbing fibers, could contribute to the ontogeny of certain forms of motor learning (e.g., eyeblink conditioning). Purkinje cell complex spikes are produced exclusively by climbing fibers and exhibit short- and long-latency activity in response to somatosensory stimulation. Previous studies have demonstrated that evoked short- and long-latency complex spikes generally occur on separate trials and that this response segregation is regulated by inhibitory feedback to the inferior olive. The present experiment tested the hypothesis that complex spikes evoked by periorbital stimulation are regulated by inhibitory feedback from the cerebellum and that this feedback develops between postnatal days (PND) 17 and 24. Recordings from individual Purkinje cell complex spikes in urethan-anesthetized rats indicated that the segregation of short- and long-latency evoked complex spike activity emerges between PND17 and PND24. In addition, infusion of picrotoxin, a GABAA-receptor antagonist, into the inferior olive abolished the response pattern segregation in PND24 rats, producing evoked complex spike response patterns similar to those characteristic of younger rats. These data support the view that cerebellar feedback to the inferior olive, which is exclusively inhibitory, undergoes substantial changes in the same developmental time window in which certain forms of motor learning emerge.

scholarly journals Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations

2017 ◽  
Vol 595 (15) ◽  
pp. 5341-5357 ◽  
Author(s):  
Tianyu Tang ◽  
Jianqiang Xiao ◽  
Colleen Y. Suh ◽  
Amelia Burroughs ◽  
Nadia L. Cerminara ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Complex Spike ◽  
Simple Spike
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