scholarly journals Brain-derived neurotrophic factor in VMH as the causal factor for and therapeutic tool to treat visceral adiposity and hyperleptinemia in type 2 diabetic Goto–Kakizaki rats

2013 ◽  
Vol 5 ◽  
Author(s):  
Fumihiko Maekawa ◽  
Ken Fujiwara ◽  
Masako Toriya ◽  
Yuko Maejima ◽  
Takashi Nishio ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Causal Factor ◽  
Visceral Adiposity ◽  
Therapeutic Tool ◽  
Type 2 Diabetic

scholarly journals Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with Amlodipine/Benazepril or Valsartan/Hydrochlorothiazide

2015 ◽  
Vol 2015 ◽  
pp. 1-8
Author(s):  
I-Te Lee ◽  
Wayne Huey-Herng Sheu ◽  
Yi-Jen Hung ◽  
Jung-Fu Chen ◽  
Chih-Yuan Wang ◽  
...  
Keyword(s):  
Glomerular Filtration ◽  
Neurotrophic Factor ◽  
Multivariate Regression Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Antihypertensive Medications ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Type 2 Diabetic ◽  
Serum Bdnf

Background. Brain-derived neurotrophic factor (BDNF) is associated with sympathetic activation. However, the effects of BDNF on diabetic nephropathy are unknown. The aim of this study was to assess the estimated glomerular filtration rates (eGFRs) and changes in serum BDNF levels in type 2 diabetic subjects treated with antihypertensive medications.Methods. In this randomized, double-blind clinical trial, type 2 diabetic subjects with hypertension were assigned to either the benazepril/amlodipine or valsartan/hydrochlorothiazide treatment groups for a 16-week period. The post hoc analyses were based on increased or decreased serum BDNF levels.Results. Of the 153 enrolled subjects, the changes in eGFR were significantly and inversely correlated with those in BDNF in the 76 subjects treated with valsartan/hydrochlorothiazide (r=-0.264,P=0.021) but not in the 77 subjects treated with benazepril/amlodipine (r=-0.025,P=0.862). The 45 subjects with increased BDNF following valsartan/hydrochlorothiazide treatment exhibited a significantly reduced eGFR (-8.8±14.9 mL/min/1.73 m2;P<0.001). Multivariate regression analysis revealed that increased serum BDNF represents an independent factor for reduced eGFR (95% confidence interval between −0.887 and −0.076,P=0.020).Conclusions. Increased serum BDNF is associated with reduced eGFR in type 2 diabetic subjects treated with valsartan/hydrochlorothiazide but not with amlodipine/benazepril.

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