scholarly journals A novel herbal treatment reduces depressive-like behaviors and increases brain-derived neurotrophic factor levels in the brain of type 2 diabetic rats

2016 ◽  
Vol Volume 12 ◽  
pp. 3051-3059 ◽  
Author(s):  
Chun Luo ◽  
Yuting Ke ◽  
Yanyan Yuan ◽  
Ming Zhao ◽  
Fuyan Wang ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Diabetic Rats ◽  
Herbal Treatment ◽  
The Brain ◽  
Type 2 Diabetic

Increased neuronal activation in sympathoregulatory regions of the brain and spinal cord in type 2 diabetic rats

2021 ◽  
Author(s):  
Shivani Sethi ◽  
Rachael A. Augustine ◽  
Gregory T. Bouwer ◽  
Michael R. Perkinson ◽  
Isaiah Cheong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diabetic Rats ◽  
Neuronal Activation ◽  
Brain And Spinal Cord ◽  
The Brain ◽  
Type 2 Diabetic

scholarly journals The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus

2021 ◽  
Vol 11 (2) ◽  
pp. 242
Author(s):  
Basem H. Elesawy ◽  
Bassem M. Raafat ◽  
Aya Al Muqbali ◽  
Amr M. Abbas ◽  
Hussein F. Sakr
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Diabetic Rats ◽  
Intermittent Fasting ◽  
Neurotrophin 3 ◽  
The Impact

Type 2 diabetes mellitus (T2DM) is known to be associated with an increased risk of dementia, specifically Alzheimer’s disease and vascular dementia. Intermittent fasting (IF) has been proposed to produce neuroprotective effects through the activation of several signaling pathways. In this study, we investigated the effect of IF on rat behavior in type 2 diabetic rats. Forty male Wistar Kyoto rats were divided into four groups (n = 10 for each): the ad libitum (Ad) group, the intermittent fasting group (IF), the streptozotocin-induced diabetic 2 group (T2DM) fed a high-fat diet for 4 weeks followed by a single intraperitoneal (i.p.) injection of streptozotocin (STZ) 25 mg kg−1, and the diabetic group with intermittent fasting (T2DM+IF). We evaluated the impact of 3 months of IF (16 h of food deprivation daily) on the levels of brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), serotonin, dopamine, and glutamate in the hippocampus, and rat behavior was assessed by the forced swim test and elevated plus maze. IF for 12 weeks significantly increased (p < 0.05) the levels of NT3 and BDNF in both control and T2DM rats. Additionally, it increased serotonin, dopamine, and glutamic acid in diabetic rats. Moreover, IF modulated glucose homeostasis parameters, with a significant decrease (p < 0.05) in insulin resistance and downregulation of serum corticosterone level. Interestingly, T2DM rats showed a significant increase in anxiety and depression behaviors, which were ameliorated by IF. These findings suggest that IF could produce a potentially protective effect by increasing the levels of BDNF and NT3 in both control and T2DM rats. IF could be considered as an additional therapy for depression, anxiety, and neurodegenerative diseases.

scholarly journals Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with Amlodipine/Benazepril or Valsartan/Hydrochlorothiazide

2015 ◽  
Vol 2015 ◽  
pp. 1-8
Author(s):  
I-Te Lee ◽  
Wayne Huey-Herng Sheu ◽  
Yi-Jen Hung ◽  
Jung-Fu Chen ◽  
Chih-Yuan Wang ◽  
...  
Keyword(s):  
Glomerular Filtration ◽  
Neurotrophic Factor ◽  
Multivariate Regression Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Antihypertensive Medications ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Type 2 Diabetic ◽  
Serum Bdnf

Background. Brain-derived neurotrophic factor (BDNF) is associated with sympathetic activation. However, the effects of BDNF on diabetic nephropathy are unknown. The aim of this study was to assess the estimated glomerular filtration rates (eGFRs) and changes in serum BDNF levels in type 2 diabetic subjects treated with antihypertensive medications.Methods. In this randomized, double-blind clinical trial, type 2 diabetic subjects with hypertension were assigned to either the benazepril/amlodipine or valsartan/hydrochlorothiazide treatment groups for a 16-week period. The post hoc analyses were based on increased or decreased serum BDNF levels.Results. Of the 153 enrolled subjects, the changes in eGFR were significantly and inversely correlated with those in BDNF in the 76 subjects treated with valsartan/hydrochlorothiazide (r=-0.264,P=0.021) but not in the 77 subjects treated with benazepril/amlodipine (r=-0.025,P=0.862). The 45 subjects with increased BDNF following valsartan/hydrochlorothiazide treatment exhibited a significantly reduced eGFR (-8.8±14.9 mL/min/1.73 m2;P<0.001). Multivariate regression analysis revealed that increased serum BDNF represents an independent factor for reduced eGFR (95% confidence interval between −0.887 and −0.076,P=0.020).Conclusions. Increased serum BDNF is associated with reduced eGFR in type 2 diabetic subjects treated with valsartan/hydrochlorothiazide but not with amlodipine/benazepril.

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