scholarly journals A knowledge based approach to matching human neurodegenerative disease and animal models

2013 ◽  
Vol 7 ◽  
Author(s):  
Sarah M. Maynard ◽  
Christopher J. Mungall ◽  
Suzanna E. Lewis ◽  
Fahim T. Imam ◽  
Maryann E. Martone
Keyword(s):  
Animal Models ◽  
Neurodegenerative Disease ◽  
Knowledge Based ◽  
Human Neurodegenerative Disease

scholarly journals Screening Pesticides for Neuropathogenicity

2006 ◽  
Vol 2006 ◽  
pp. 1-13 ◽  
Author(s):  
John D. Doherty
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Animal Models ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Laboratory Animals ◽  
The Public ◽  
Delayed Neuropathy ◽  
Time Of Administration ◽  
Human Neurodegenerative Disease

Pesticides are routinely screened in studies that follow specific guidelines for possible neuropathogenicity in laboratory animals. These tests will detect chemicals that are by themselves strong inducers of neuropathogenesis if the tested strain is susceptible relative to the time of administration and methodology of assessment. Organophosphate induced delayed neuropathy (OPIDN) is the only known human neurodegenerative disease associated with pesticides and the existing study guidelines with hens are a standard for predicting the potential for organophosphates to cause OPIDN. Although recent data have led to the suggestion that pesticides may be risk factors for Parkinsonism syndrome, there are no specific protocols to evaluate this syndrome in the existing study guidelines. Ideally additional animal models for human neurodegenerative diseases need to be developed and incorporated into the guidelines to further assure the public that limited exposure to pesticides is not a risk factor for neurodegenerative diseases.

scholarly journals Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases

2021 ◽  
Vol 22 (19) ◽  
pp. 10766
Author(s):  
Jing Wang ◽  
Hong Cao
Keyword(s):  
Animal Models ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Large Scale ◽  
Gene Knockout ◽  
Forward Genetics ◽  
Suitable Model ◽  
Human Beings ◽  
Fast Development ◽  
Human Neurodegenerative Disease

Animal models of human neurodegenerative disease have been investigated for several decades. In recent years, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become popular in pathogenic and therapeutic studies about human neurodegenerative diseases due to their small size, the optical clarity of embryos, their fast development, and their suitability to large-scale therapeutic screening. Following the emergence of a new generation of molecular biological technologies such as reverse and forward genetics, morpholino, transgenesis, and gene knockout, many human neurodegenerative disease models, such as Parkinson’s, Huntington’s, and Alzheimer’s, were constructed in zebrafish and medaka. These studies proved that zebrafish and medaka genes are functionally conserved in relation to their human homologues, so they exhibit similar neurodegenerative phenotypes to human beings. Therefore, fish are a suitable model for the investigation of pathologic mechanisms of neurodegenerative diseases and for the large-scale screening of drugs for potential therapy. In this review, we summarize the studies in modelling human neurodegenerative diseases in zebrafish and medaka in recent years.

Experimental Aluminum Encephalomyelopathy: Relationship to Human Neurodegenerative Disease

1998 ◽  
Vol 18 (4) ◽  
pp. 687-698 ◽  
Author(s):  
Jagannatha K.S. Rao ◽  
Christos D. Katsetos ◽  
Mary M. Herman ◽  
John Savory
Keyword(s):  
Neurodegenerative Disease ◽  
Human Neurodegenerative Disease

scholarly journals BACE2 Expression Increases in Human Neurodegenerative Disease

2012 ◽  
Vol 180 (1) ◽  
pp. 337-350 ◽  
Author(s):  
Christopher J. Holler ◽  
Robin L. Webb ◽  
Ashley L. Laux ◽  
Tina L. Beckett ◽  
Dana M. Niedowicz ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Human Neurodegenerative Disease

Naujagimių ir kūdikių smegenų ląastelių apoptozė ir perioperacinis periodas: ar yra ryšys?

2013 ◽  
Vol 23 (1) ◽  
pp. 133-137 ◽  
Author(s):  
Ilona Šuškevičienė ◽  
Milda Nekrašienė ◽  
Danguolė Rugytė ◽  
Alina Vilkė ◽  
Tomas Bukauskas ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Animal Models ◽  
Biological Markers ◽  
Current Knowledge ◽  
Cell Damage ◽  
Epidemiological Studies ◽  
Damage Scenarios ◽  
Knowledge Based ◽  
Specific Proteins ◽  
Brain Specific Proteins

In these latter decades neurotoxicity of general anaesthetics has been demonstrated in neonatal animal models. These data raised a concern about the safety of neonatal and paediatric anaesthesia. However, prospective epidemiological studies in humans are still ongoing. Biological markers, which could be associated with anaesthesia and outcome would be helpful in timely decisions regarding clinical practice in newborns and infants. To date, some brain specific proteins have been studies in various brain damage scenarios in neonates, children and adults. The purpose of the present paper is to describe current knowledge, based on experimental and clinical data, on the influence of anaesthetics on the developing brain and the applicability of certain biomarkers in cases of cerebral cell damage.

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