scholarly journals Misfolded, protease-resistant proteins in animal models and human neurodegenerative disease

2002 ◽  
Vol 110 (10) ◽  
pp. 1403-1405 ◽  
Author(s):  
Dennis W. Dickson
Keyword(s):  
Animal Models ◽  
Neurodegenerative Disease ◽  
Human Neurodegenerative Disease

scholarly journals A knowledge based approach to matching human neurodegenerative disease and animal models

2013 ◽  
Vol 7 ◽  
Author(s):  
Sarah M. Maynard ◽  
Christopher J. Mungall ◽  
Suzanna E. Lewis ◽  
Fahim T. Imam ◽  
Maryann E. Martone
Keyword(s):  
Animal Models ◽  
Neurodegenerative Disease ◽  
Knowledge Based ◽  
Human Neurodegenerative Disease

scholarly journals Screening Pesticides for Neuropathogenicity

2006 ◽  
Vol 2006 ◽  
pp. 1-13 ◽  
Author(s):  
John D. Doherty
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Animal Models ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Laboratory Animals ◽  
The Public ◽  
Delayed Neuropathy ◽  
Time Of Administration ◽  
Human Neurodegenerative Disease

Pesticides are routinely screened in studies that follow specific guidelines for possible neuropathogenicity in laboratory animals. These tests will detect chemicals that are by themselves strong inducers of neuropathogenesis if the tested strain is susceptible relative to the time of administration and methodology of assessment. Organophosphate induced delayed neuropathy (OPIDN) is the only known human neurodegenerative disease associated with pesticides and the existing study guidelines with hens are a standard for predicting the potential for organophosphates to cause OPIDN. Although recent data have led to the suggestion that pesticides may be risk factors for Parkinsonism syndrome, there are no specific protocols to evaluate this syndrome in the existing study guidelines. Ideally additional animal models for human neurodegenerative diseases need to be developed and incorporated into the guidelines to further assure the public that limited exposure to pesticides is not a risk factor for neurodegenerative diseases.

scholarly journals Zebrafish and Medaka: Important Animal Models for Human Neurodegenerative Diseases

2021 ◽  
Vol 22 (19) ◽  
pp. 10766
Author(s):  
Jing Wang ◽  
Hong Cao
Keyword(s):  
Animal Models ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Large Scale ◽  
Gene Knockout ◽  
Forward Genetics ◽  
Suitable Model ◽  
Human Beings ◽  
Fast Development ◽  
Human Neurodegenerative Disease

Animal models of human neurodegenerative disease have been investigated for several decades. In recent years, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become popular in pathogenic and therapeutic studies about human neurodegenerative diseases due to their small size, the optical clarity of embryos, their fast development, and their suitability to large-scale therapeutic screening. Following the emergence of a new generation of molecular biological technologies such as reverse and forward genetics, morpholino, transgenesis, and gene knockout, many human neurodegenerative disease models, such as Parkinson’s, Huntington’s, and Alzheimer’s, were constructed in zebrafish and medaka. These studies proved that zebrafish and medaka genes are functionally conserved in relation to their human homologues, so they exhibit similar neurodegenerative phenotypes to human beings. Therefore, fish are a suitable model for the investigation of pathologic mechanisms of neurodegenerative diseases and for the large-scale screening of drugs for potential therapy. In this review, we summarize the studies in modelling human neurodegenerative diseases in zebrafish and medaka in recent years.

Experimental Aluminum Encephalomyelopathy: Relationship to Human Neurodegenerative Disease

1998 ◽  
Vol 18 (4) ◽  
pp. 687-698 ◽  
Author(s):  
Jagannatha K.S. Rao ◽  
Christos D. Katsetos ◽  
Mary M. Herman ◽  
John Savory
Keyword(s):  
Neurodegenerative Disease ◽  
Human Neurodegenerative Disease

scholarly journals BACE2 Expression Increases in Human Neurodegenerative Disease

2012 ◽  
Vol 180 (1) ◽  
pp. 337-350 ◽  
Author(s):  
Christopher J. Holler ◽  
Robin L. Webb ◽  
Ashley L. Laux ◽  
Tina L. Beckett ◽  
Dana M. Niedowicz ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Human Neurodegenerative Disease
Sign in / Sign up

Export Citation Format

Share Document