scholarly journals Can Your DNA Influence Your Bet-Placing? The Impact of Cannabinoid Receptor 1 Gene on Gambling Tasks

2018 ◽  
Vol 12 ◽  
Author(s):  
Huihui Qin ◽  
Jianmin Zeng ◽  
Hong Chen ◽  
Ling Deng ◽  
Li Su
Keyword(s):  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1 ◽  
The Impact

scholarly journals Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis

2021 ◽  
Vol 22 (14) ◽  
pp. 7388
Author(s):  
Thomas Murphy ◽  
Justin Matheson ◽  
Robert E. Mann ◽  
Bruna Brands ◽  
Christine M. Wickens ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Subjective Effects ◽  
Area Under The Curve ◽  
Controlled Clinical Trial ◽  
Cannabinoid Receptor 1 ◽  
Maximum Value ◽  
Global Trend ◽  
The World ◽  
Double Blinded ◽  
The Impact

As many jurisdictions consider relaxing cannabis legislation and usage is increasing in North America and other parts of the world, there is a need to explore the possible genetic differences underlying the subjective effects of cannabis. This pilot study investigated specific genetic variations within the cannabinoid receptor 1 (CNR1) gene for association with the subjective effects of smoked cannabis. Data were obtained from a double-blinded, placebo-controlled clinical trial studying the impact of cannabis intoxication on driving performance. Participants randomized to the active cannabis group who consented to secondary genetic analysis (n = 52) were genotyped at the CNR1 rs1049353 and rs2023239 polymorphic areas. Maximum value and area under the curve (AUC) analyses were performed on subjective measures data. Analysis of subjective effects by genotype uncovered a global trend towards greater subjective effects for rs1049353 T-allele- and rs2023239 C-allele-carrying subjects. However, significant differences attributed to allelic identity were only documented for a subset of subjective effects. Our findings suggest that rs1049353 and rs2023239 minor allele carriers experience augmented subjective effects during acute cannabis intoxication.

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis

2020 ◽  
Vol 29 (7) ◽  
pp. 616-622 ◽  
Author(s):  
Attila Oláh ◽  
Majid Alam ◽  
Jérémy Chéret ◽  
Nikolett Gréta Kis ◽  
Zoltán Hegyi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cannabinoid Receptor ◽  
Human Epidermis ◽  
Cannabinoid Receptor 1 ◽  
Mitochondrial Energy Metabolism

scholarly journals Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice

2016 ◽  
Vol 332 ◽  
pp. 217-222 ◽  
Author(s):  
Katrina L. Toal ◽  
Kelly E. Radziwon ◽  
David P. Holfoth ◽  
Matthew A. Xu-Friedman ◽  
Micheal L. Dent
Keyword(s):  
Knockout Mice ◽  
Cannabinoid Receptor ◽  
Frequency Difference ◽  
Gap Detection ◽  
Cannabinoid Receptor 1 ◽  
Detection Thresholds

Effects on Food Intake and Blood Lipids of Cannabinoid Receptor 1 Antagonist Treatment in Lean Rats

Obesity ◽  
2008 ◽  
Vol 16 (11) ◽  
pp. 2451-2455 ◽  
Author(s):  
Marianne F. Bennetzen ◽  
Maria P. Nielsen ◽  
Bjørn Richelsen ◽  
Steen B. Pedersen
Keyword(s):  
Food Intake ◽  
Blood Lipids ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1
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