scholarly journals Inhibition of DRP-1-Dependent Mitophagy Promotes Cochlea Hair Cell Senescence and Exacerbates Age-Related Hearing Loss

2019 ◽  
Vol 13 ◽  
Author(s):  
Hanqing Lin ◽  
Hao Xiong ◽  
Zhongwu Su ◽  
Jiaqi Pang ◽  
Lan Lai ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Cell Senescence ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Noise-induced and age-related hearing loss:  new perspectives and potential therapies

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 927 ◽  
Author(s):  
M Charles Liberman
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Sensorineural Hearing Loss ◽  
Hair Cells ◽  
Auditory Nerve ◽  
Cell Loss ◽  
Sensorineural Hearing ◽  
Hair Cell Loss ◽  
Age Related ◽  
Age Related Hearing Loss

The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of the synaptic connections between hair cells and the auditory nerve. Similarly, in age-related hearing loss, degeneration of cochlear synapses precedes both hair cell loss and threshold elevation. This primary neural degeneration has remained a “hidden hearing loss” for two reasons: 1) the neuronal cell bodies survive for years despite loss of synaptic connection with hair cells, and 2) the degeneration is selective for auditory nerve fibers with high thresholds. Although not required for threshold detection when quiet, these high-threshold fibers are critical for hearing in noisy environments. Research suggests that primary neural degeneration is an important contributor to the perceptual handicap in sensorineural hearing loss, and it may be key to the generation of tinnitus and other associated perceptual anomalies. In cases where the hair cells survive, neurotrophin therapies can elicit neurite outgrowth from surviving auditory neurons and re-establishment of their peripheral synapses; thus, treatments may be on the horizon.

A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss

2016 ◽  
Vol 332 ◽  
pp. 137-150 ◽  
Author(s):  
Margarete A. Ueberfuhr ◽  
Hannah Fehlberg ◽  
Shawn S. Goodman ◽  
Robert H. Withnell
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Outer Hair Cell ◽  
Cell Integrity ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss

2018 ◽  
Vol 38 (13) ◽  
pp. 3177-3189 ◽  
Author(s):  
Teerawat Wiwatpanit ◽  
Natalie N. Remis ◽  
Aisha Ahmad ◽  
Yingjie Zhou ◽  
John C. Clancy ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Hair Cells ◽  
Outer Hair Cell ◽  
Cochlear Hair Cells ◽  
Age Related ◽  
Age Related Hearing Loss ◽  
Cell Longevity

RETRACTED: miR-34a/Bcl-2 signaling pathway contributes to age-related hearing loss by modulating hair cell apoptosis

2017 ◽  
Vol 661 ◽  
pp. 51-56 ◽  
Author(s):  
Qiuhong Huang ◽  
Yiqing Zheng ◽  
Yongkang Ou ◽  
Hao Xiong ◽  
Haidi Yang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Age Related ◽  
Age Related Hearing Loss

Recent advances in cochlear hair cell regeneration—A promising opportunity for the treatment of age-related hearing loss

2017 ◽  
Vol 36 ◽  
pp. 149-155 ◽  
Author(s):  
Miren Revuelta ◽  
Francisco Santaolalla ◽  
Olatz Arteaga ◽  
Antonia Alvarez ◽  
Ana Sánchez-del-Rey ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Cell Regeneration ◽  
Hair Cell Regeneration ◽  
Cochlear Hair Cell ◽  
Recent Advances ◽  
Age Related ◽  
Age Related Hearing Loss
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