Recent advances in cochlear hair cell regeneration—A promising opportunity for the treatment of age-related hearing loss

2017 ◽  
Vol 36 ◽  
pp. 149-155 ◽  
Author(s):  
Miren Revuelta ◽  
Francisco Santaolalla ◽  
Olatz Arteaga ◽  
Antonia Alvarez ◽  
Ana Sánchez-del-Rey ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Cell Regeneration ◽  
Hair Cell Regeneration ◽  
Cochlear Hair Cell ◽  
Recent Advances ◽  
Age Related ◽  
Age Related Hearing Loss

SIRT1 protects cochlear hair cell and delays age-related hearing loss via autophagy

2019 ◽  
Vol 80 ◽  
pp. 127-137 ◽  
Author(s):  
Jiaqi Pang ◽  
Hao Xiong ◽  
Yongkang Ou ◽  
Haidi Yang ◽  
Yaodong Xu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Cochlear Hair Cell ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Noise-induced and age-related hearing loss:  new perspectives and potential therapies

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 927 ◽  
Author(s):  
M Charles Liberman
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Sensorineural Hearing Loss ◽  
Hair Cells ◽  
Auditory Nerve ◽  
Cell Loss ◽  
Sensorineural Hearing ◽  
Hair Cell Loss ◽  
Age Related ◽  
Age Related Hearing Loss

The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of the synaptic connections between hair cells and the auditory nerve. Similarly, in age-related hearing loss, degeneration of cochlear synapses precedes both hair cell loss and threshold elevation. This primary neural degeneration has remained a “hidden hearing loss” for two reasons: 1) the neuronal cell bodies survive for years despite loss of synaptic connection with hair cells, and 2) the degeneration is selective for auditory nerve fibers with high thresholds. Although not required for threshold detection when quiet, these high-threshold fibers are critical for hearing in noisy environments. Research suggests that primary neural degeneration is an important contributor to the perceptual handicap in sensorineural hearing loss, and it may be key to the generation of tinnitus and other associated perceptual anomalies. In cases where the hair cells survive, neurotrophin therapies can elicit neurite outgrowth from surviving auditory neurons and re-establishment of their peripheral synapses; thus, treatments may be on the horizon.

scholarly journals Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

Neuron ◽  
2013 ◽  
Vol 78 (2) ◽  
pp. 403 ◽  
Author(s):  
Kunio Mizutari ◽  
Masato Fujioka ◽  
Makoto Hosoya ◽  
Naomi Bramhall ◽  
Hirotaka James Okano ◽  
...  
Keyword(s):  
Hair Cell ◽  
Acoustic Trauma ◽  
Cell Regeneration ◽  
Hair Cell Regeneration ◽  
Cochlear Hair Cell ◽  
Notch Inhibition

scholarly journals Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Yan Chen ◽  
Huiqian Yu ◽  
Yanping Zhang ◽  
Wen Li ◽  
Na Lu ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Regeneration ◽  
Hair Cell Regeneration ◽  
Cochlear Hair Cell
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