scholarly journals Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor

2014 ◽  
Vol 8 ◽  
Author(s):  
Janine M. Prast ◽  
Aurelia Schardl ◽  
Christoph Schwarzer ◽  
Georg Dechant ◽  
Alois Saria ◽  
...  
Keyword(s):  
Social Interaction ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Medium Spiny Neurons ◽  
Spiny Neurons

scholarly journals Conditioned place preference for social interaction in rats: contribution of sensory components

2011 ◽  
Vol 5 ◽  
Author(s):  
Kummer Kai ◽  
Klement Sabine ◽  
Eggart Vincent ◽  
J. Mayr Michael ◽  
Saria Alois ◽  
...  
Keyword(s):  
Social Interaction ◽  
Conditioned Place Preference ◽  
Place Preference

Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats

2011 ◽  
Vol 16 (2) ◽  
pp. 273-284 ◽  
Author(s):  
Michael Fritz ◽  
Rana El Rawas ◽  
Ahmad Salti ◽  
Sabine Klement ◽  
Michael T. Bardo ◽  
...  
Keyword(s):  
Social Interaction ◽  
Conditioned Place Preference ◽  
Place Preference

scholarly journals Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction

2012 ◽  
Vol 6 ◽  
Author(s):  
Rana El Rawas ◽  
Sabine Klement ◽  
Kai K. Kummer ◽  
Michael Fritz ◽  
Georg Dechant ◽  
...  
Keyword(s):  
Social Interaction ◽  
Conditioned Place Preference ◽  
Brain Regions ◽  
Place Preference

scholarly journals The presence of a social stimulus reduces cocaine-seeking in a place preference conditioning paradigm

2019 ◽  
Vol 33 (12) ◽  
pp. 1501-1511 ◽  
Author(s):  
Patricia Sampedro-Piquero ◽  
Fabiola Ávila-Gámiz ◽  
Román D Moreno Fernández ◽  
Estela Castilla-Ortega ◽  
Luis J Santín
Keyword(s):  
Substance Use ◽  
Social Interaction ◽  
Conditioned Place Preference ◽  
Substance Use Disorders ◽  
Test Session ◽  
Place Preference ◽  
Housing Condition ◽  
Social Stimulus ◽  
Novel Object ◽  
The Social

Background: One challenge in the treatment of substance use disorders is to re-engage the interest toward non-drug-related activities. Among these activities, social interaction has had a prominent role due to its positive influence on treatment outcome. Aims and methods: Our aim was to study whether the presence of a social stimulus during the cocaine-induced conditioned place preference test was able to reduce the time spent in the drug-paired compartment. For that purpose, mice were trained for four days on a conditioned place preference task with one compartment paired with cocaine and the opposite with saline. On the test day, we introduced an unfamiliar juvenile male mouse into the saline-conditioned compartment (inside a pencil cup) to analyse the animal preference towards the two rewarding stimuli (cocaine vs mouse). Additionally, to discard the possible effect of novelty, as well as the housing condition (social isolation) on social preference, we decided to include a novel object during the test session, as well as perform the same conditioned place preference protocol with a group of animals in social housing conditions. Results: The social stimulus was able to reduce the preference for cocaine and enhance the active interaction with the juvenile mouse (sniffing) compared to the empty pencil cup paired with the drug. The introduction of a novel object during the test session did not reduce the preference for the cocaine-paired compartment, and interestingly, the preference for the social stimulus was independent of the housing condition. c-Fos immunohistochemistry revealed a different pattern of activation based on cocaine-paired conditioning or the presence of social stimulus. Conclusions: These results suggest that social interaction could constitute a valuable component in the treatment of substance use disorders by reducing the salience of the drug.

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