scholarly journals Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction

2012 ◽  
Vol 6 ◽  
Author(s):  
Rana El Rawas ◽  
Sabine Klement ◽  
Kai K. Kummer ◽  
Michael Fritz ◽  
Georg Dechant ◽  
...  
Keyword(s):  
Social Interaction ◽  
Conditioned Place Preference ◽  
Brain Regions ◽  
Place Preference

scholarly journals Conditioned place preference for social interaction in rats: contribution of sensory components

2011 ◽  
Vol 5 ◽  
Author(s):  
Kummer Kai ◽  
Klement Sabine ◽  
Eggart Vincent ◽  
J. Mayr Michael ◽  
Saria Alois ◽  
...  
Keyword(s):  
Social Interaction ◽  
Conditioned Place Preference ◽  
Place Preference

scholarly journals Cannabidiol attenuates methamphetamine-induced conditioned place preference via the Sigma1R/AKT/GSK-3β/CREB signaling pathway in rats

2020 ◽  
Vol 9 (3) ◽  
pp. 202-211 ◽  
Author(s):  
Genmeng Yang ◽  
Liu Liu ◽  
Ruilin Zhang ◽  
Juan Li ◽  
Chi-Kwan Leung ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Conditioned Place Preference ◽  
Intraperitoneal Injection ◽  
Brain Regions ◽  
Cellular Protein ◽  
Place Preference ◽  
Therapeutic Effects ◽  
Expression Levels ◽  
Dose Dependent Fashion ◽  
Gsk 3Β

Abstract Methamphetamine (METH) is a highly addictive psychostimulant. Cannabidiol (CBD) is an exogenous cannabinoid without psychostimulating activity, which has potential therapeutic effects on opioid addiction. However, it is unclear whether CBD has therapeutic effects on METH-induced motivational effects. The present study examines whether CBD has a protective effect on METH-induced conditioned place preference (CPP) in rats by regulating the Sigma1R and AKT-GSK3β-CREB signaling pathway. Seventy rats were equally and randomly divided into seven groups. The rat CPP model was established via the intraperitoneal injection (IP) of 2 mg/kg of METH. Next, the intraperitoneal injection of 10, 20, 40, and 80 mg/kg CBD was performed 1 h prior to the injection of saline or METH. The protein expression levels of Sigma1R, AKT, p-AKT, GSK-3β, p-GSK-3β, CREB, and p-CREB in the rats’ prefrontal cortex, nucleus accumbens, and hippocampus and ventral tegmental were detected using western blot analysis. CBD was found to inhibit METH-induced CPP in a dose-dependent fashion. The expression levels of Sigma1R, p-AKT, p-GSK3β, and p-CREB increased significantly in the METH-induced CPP model. Treatment involving different doses of CBD caused differential inhibitory responses in the cellular protein abundance of Sigma1R, p-AKT, p-GSK3β, and p-CREB across various brain regions. The present study found that METH can induce CPP in rats. When a pretreatment of CBD is applied, the CBD can weaken CPP in METH-induced rats by regulating the SigmaR1/AKT/GSK-3β/CREB signaling pathway. The results of this study indicate that CBD has a potential therapeutic effect on METH-induced rewarding effects.

Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats

2011 ◽  
Vol 16 (2) ◽  
pp. 273-284 ◽  
Author(s):  
Michael Fritz ◽  
Rana El Rawas ◽  
Ahmad Salti ◽  
Sabine Klement ◽  
Michael T. Bardo ◽  
...  
Keyword(s):  
Social Interaction ◽  
Conditioned Place Preference ◽  
Place Preference

Conditioned place preference of kisspeptin-10

2021 ◽  
Vol 19 (1) ◽  
pp. 47-53
Author(s):  
Ilia Yu. Tissen ◽  
Polina A. Chepik ◽  
Andrei A. Lebedev ◽  
Leila A. Magarramova ◽  
Eugenii R. Bychkov ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Open Field Test ◽  
Physiological Saline ◽  
Preference Test ◽  
Brain Regions ◽  
Place Preference ◽  
Male Rats ◽  
Plus Maze ◽  
Male Wistar Rats ◽  
Positive State

INTRODUCTION: Kisspeptins (KISS), a group of brain neuropeptides are involved in sexual behavior. KISS activate the hypothalamic neurons that synthesize gonadotropin releasing hormone. KISS was also detected in the limbic system. Earlier, we showed the activation of sexual motivation after the administration of kisspeptin-10 without increasing the level of testosterone in male rats, which suggests the extrahypothalamic effect of KISS. The aim of this work was to study the possibility of aquisition of conditioned place preference of kisspeptin-10, as well as to study the emotional and investigational behavior in rats after intranasal peptide administration. METHODS: Conditioned place preference test (CPP), open field test (OP) and elevated plus maze (EPM) were used in male Wistar rats. RESULTS: When studying CPP, animals spent 78.6 6.3% of the time in the chamber associated with the administration of KISS compared to control animals with administration of physiological saline (51.2% of the experiment time; p 0.05). After kisspeptin-10 administration locomotor activity was 2-fold increased (p 0.05), and the number of sniffings was 2-fold increased too (p 0.05). The parameters did not significantly differ in animals treated with kisspeptin or saline in PCL. CONCLUSION: Thus repeated intranasal administration of kisspeptin-10 induces the aquisition of CPP in rats. This suggests that kisspeptin-10 can cause activity in the reward system or the activation of brain regions associated with this system, which ultimately leads to the formation of an emotionally positive state.

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