scholarly journals Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit

2013 ◽  
Vol 7 ◽  
Author(s):  
Fabricio H. Do-Monte ◽  
Jose Rodriguez-Romaguera ◽  
Luis E. Rosas-Vidal ◽  
Gregory J. Quirk
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Fear Extinction ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression

2009 ◽  
Vol 65 (4) ◽  
pp. 267-275 ◽  
Author(s):  
Donald A. Malone ◽  
Darin D. Dougherty ◽  
Ali R. Rezai ◽  
Linda L. Carpenter ◽  
Gerhard M. Friehs ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression ◽  
Deep Brain ◽  
Stimulation Of

Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum Reproducibly Improves Symptoms of Body Dysmorphic Disorder

2016 ◽  
Vol 9 (6) ◽  
pp. 957-959 ◽  
Author(s):  
Juan Carlos Baldermann ◽  
Sina Kohl ◽  
Veerle Visser-Vandewalle ◽  
Martin Klehr ◽  
Daniel Huys ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Body Dysmorphic Disorder ◽  
Deep Brain ◽  
Stimulation Of

S.07.05 Deep brain stimulation of the ventral striatum affects consummatory and motivated behaviour in a location-specific manner

2011 ◽  
Vol 21 ◽  
pp. S196-S197
Author(s):  
G. van der Plasse ◽  
R. Schrama ◽  
S. van Seters ◽  
H.G.M. Westenberg ◽  
L.J.M.J. Vanderschuren
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Specific Manner ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Deep Brain Stimulation of the ventral striatum impairs extinction of morphine place preference (LB76)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Janelle Miranda ◽  
Freddyson Martinez ◽  
José Rodríguez ◽  
Fabricio Do Monte ◽  
Oscar Muñiz ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Place Preference ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus

2019 ◽  
Vol 9 (10) ◽  
pp. 264 ◽  
Author(s):  
Juan Baldermann ◽  
Lisa Hahn ◽  
Till Dembek ◽  
Sina Kohl ◽  
Jens Kuhn ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Food Intake ◽  
Brain Stimulation ◽  
Ventral Striatum ◽  
Therapeutic Potential ◽  
Weight Changes ◽  
Bed Nucleus ◽  
Compulsive Disorder ◽  
Deep Brain ◽  
Stimulation Of

Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential.

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