scholarly journals ARS2 Plays Diverse Roles in DNA Damage Response, Fungal Development, and Pathogenesis in the Plant Pathogenic Fungus Fusarium graminearum

2019 ◽  
Vol 10 ◽  
Author(s):  
Duc-Cuong Bui ◽  
Jung-Eun Kim ◽  
Jiyoung Shin ◽  
Jae Yun Lim ◽  
Gyung Ja Choi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Fusarium Graminearum ◽  
Dna Damage Response ◽  
Pathogenic Fungus ◽  
Fungal Development ◽  
Plant Pathogenic Fungus ◽  
Damage Response

scholarly journals A novel transcription factor gene FHS1 is involved in the DNA damage response in Fusarium graminearum

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Hokyoung Son ◽  
Minmin Fu ◽  
Yoonji Lee ◽  
Jae Yun Lim ◽  
Kyunghun Min ◽  
...  
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Fusarium Graminearum ◽  
Dna Damage Response ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Damage Response

scholarly journals Genetic interaction between Ptc2 and protein phosphatase 4 (PP4) in the regulation of DNA damage response and virulence in Candida albicans

2019 ◽  
Vol 19 (8) ◽  
Author(s):  
Jia Feng ◽  
Aidi Shan ◽  
Jing Hu ◽  
Zhenyu Cao ◽  
Rui Lv ◽  
...  
Keyword(s):  
Dna Damage ◽  
Candida Albicans ◽  
Dna Damage Response ◽  
Protein Phosphatase ◽  
Genetic Interaction ◽  
Pathogenic Fungus ◽  
Single Gene ◽  
Critical Role ◽  
Genotoxic Stress ◽  
Damage Response

ABSTRACT In the pathogenic fungus Candida albicans, phosphoregulation of the checkpoint kinase Rad53 plays a crucial role in the filamentous growth response to genotoxic stresses. The protein phosphatase 4 (PP4) complex, containing Pph3 and either Psy2 or Psy4, is proved to play a critical role in Rad53 dephosphorylation. In previous studies, we characterized CaPtc2 (the ortholog of both Ptc2 and Ptc3 in Saccharomyces cerevisiae) as a potential DNA-damage-related protein phosphatase. In this study, we checked the genetic interaction of PTC2 with the PP4 complex in the DNA damage response pathway. The results suggest that Ptc2 shows a negative genetic interaction with Pph3, but positive genetic interaction with either Psy2 or Psy4 in response to genotoxic stress. Deletion of PTC2 alone resulted in no significant change in cell virulence, but double deletion of PTC2 PPH3 significantly decreased virulence, while double deletions of either PTC2 PSY2 or PTC2 PSY4 caused virulence levels similar to that shown by PSY2 or PSY4 single-gene deletion cells. Taken together, we propose that Ptc2 in C. albicans plays a compensatory role for Pph3 but is dependent on Psy2 and Psy4 in regulation of DNA damage and cell virulence.

2118-P: Regulation of Ataxia-Telangiectasia and Rad3-Related (ATR)–Dependent DNA Damage Response by Nitric Oxide in ß-Cells

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2118-P
Author(s):  
CHAY TENG YEO ◽  
BRYNDON OLESON ◽  
JOHN A. CORBETT ◽  
JAMIE K. SCHNUCK
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Ataxia Telangiectasia ◽  
Damage Response

DNA damage response and neuroprotection

10.2741/2862 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 2504 ◽  
Author(s):  
Inna, I. Kruman
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response
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