scholarly journals A novel transcription factor gene FHS1 is involved in the DNA damage response in Fusarium graminearum

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Hokyoung Son ◽  
Minmin Fu ◽  
Yoonji Lee ◽  
Jae Yun Lim ◽  
Kyunghun Min ◽  
...  
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Fusarium Graminearum ◽  
Dna Damage Response ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Damage Response

scholarly journals The Mef/Elf4 Transcription Factor Fine Tunes the DNA Damage Response

2011 ◽  
Vol 71 (14) ◽  
pp. 4857-4865 ◽  
Author(s):  
Goro Sashida ◽  
Narae Bae ◽  
Silvana Di Giandomenico ◽  
Takashi Asai ◽  
Nadia Gurvich ◽  
...  
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1

2018 ◽  
Vol 9 (9) ◽  
Author(s):  
Aline Kowalski-Chauvel ◽  
Anouchka Modesto ◽  
Valerie Gouaze-andersson ◽  
Laurent Baricault ◽  
Julia Gilhodes ◽  
...  
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Dna Damage Response ◽  
Damage Response

scholarly journals A ChIP–chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response

2009 ◽  
Vol 37 (4) ◽  
pp. 1073-1085 ◽  
Author(s):  
Mattia Frontini ◽  
Meeraa Vijayakumar ◽  
Alexander Garvin ◽  
Nicole Clarke
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Dna Damage Response ◽  
Damage Response ◽  
Chip Chip

scholarly journals Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

2020 ◽  
Author(s):  
Andrew M. Cobb ◽  
Syabira Yusoff ◽  
Robert Hayward ◽  
Sadia Ahmad ◽  
Mengxi Sun ◽  
...  
Keyword(s):  
Dna Damage ◽  
Transcription Factor ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Dna Damage Response ◽  
Genotoxic Stress ◽  
Dna Damage Signaling ◽  
Damage Response ◽  
Related Transcription Factor ◽  
Osteogenic Gene

Objective: The development of ectopic vascular calcification is strongly linked with organismal aging, which is primarily caused by the accumulation of DNA damage over time. As Runx2 (Runt-related transcription factor 2) has been identified as a regulator of vascular smooth muscle cell osteogenic transition, a key component of vascular calcification, we examined the relationship between DNA damage and Runx2 activation. Approach and Results: We found genotoxic stress-stimulated Runx2 accumulation and transactivation of its osteogenic target genes, leading to enhanced calcification. Inhibition of DNA damage signaling attenuated this response. Runx2 localized to sites of DNA damage and participated in DNA repair by regulating phosphorylation events on histone H2AX, with exogenous expression of Runx2 resulting in unrepaired DNA damage and increased apoptosis. Mechanistically, Runx2 was PARylated in response to genotoxic stress, and inhibition of this modification disrupted its localization at DNA lesions and reduced its binding to osteogenic gene promoters. Conclusions: These data identify Runx2 as a novel component of the DNA damage response, coupling DNA damage signaling to both osteogenic gene transcription and apoptosis and providing a mechanism for accelerated mineralization in aging and chronic disease.

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