scholarly journals Streptococcus infantis, Streptococcus mitis, and Streptococcus oralis Strains With Highly Similar cps5 Loci and Antigenic Relatedness to Serotype 5 Pneumococci

2019 ◽  
Vol 9 ◽  
Author(s):  
Fabiana Pimenta ◽  
Robert E. Gertz ◽  
So Hee Park ◽  
Ellie Kim ◽  
Iaci Moura ◽  
...  
Keyword(s):  
Streptococcus Mitis ◽  
Streptococcus Oralis ◽  
Antigenic Relatedness ◽  
Serotype 5

scholarly journals A Case of Recurrent Erysipelas Caused by Streptococcus mitis Group

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
David Nygren ◽  
Bo Nilson ◽  
Magnus Rasmussen
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Medical History ◽  
Clinical Picture ◽  
Breast Cancer Surgery ◽  
Past Medical History ◽  
Node Dissection ◽  
Streptococcus Mitis ◽  
Streptococcus Oralis ◽  
Causative Agents

The aetiology of erysipelas remains poorly defined though beta-haemolytic streptococci are considered as the main causative pathogens. We describe a case of a 70-year-old woman with recurrent erysipelas in her left arm due to infection with streptococci of the mitis group. Her past medical history includes lymphoedema of the left arm secondary to lymph node dissection due to breast cancer surgery. On seven different occasions during a decade, she has presented a clinical picture of erysipelas and in three of them with Streptococcus mitis group bacteraemia. The results indicate that two cases were caused by Streptococcus mitis and one case was caused by Streptococcus oralis. This is, to our knowledge, the first reported cases of S. mitis and of S. oralis as the causative agents of erysipelas.

scholarly journals Vaccination With the Commensal Streptococcus mitis Expressing Pneumococcal Serotype 5 Capsule Elicits IgG/IgA and Th17 Responses Against Streptococcus pneumoniae

2021 ◽  
Vol 12 ◽  
Author(s):  
Sudhanshu Shekhar ◽  
Heidi A. Åmdal ◽  
Fernanda Cristina Petersen
Keyword(s):  
Streptococcus Pneumoniae ◽  
Protective Immunity ◽  
Mediastinal Lymph Node ◽  
Pneumococcal Infection ◽  
Streptococcus Mitis ◽  
Serotype 5 ◽  
Pneumococcal Serotype ◽  
Iga Antibody ◽  
Antibody Levels

Recent studies have identified a clinical isolate of the commensal Streptococcus mitis that expresses Streptococcus pneumoniae serotype 5 capsule (S. mitis serotype 5) and shows serospecificity toward pneumococcal serotype 5. However, it remains unknown whether S. mitis serotype 5 induces protective immunity against pneumococcal serotype 5. In this study, we evaluated the ability of S. mitis serotype 5 to generate protective immunity in a mouse model of lung infection with pneumococcal serotype 5. Upon challenge infection with S. pneumoniae serotype 5, mice intranasally immunized with S. mitis serotype 5 exhibited reduced pneumococcal loads in the lungs, nasal wash, and bronchoalveolar lavage fluid compared with those receiving PBS (control). The immunized mice displayed significantly higher levels of IgG and IgA antibodies reactive to S. mitis serotype 5, S. pneumoniae serotype 5 or S. pneumoniae serotype 4 than the antibody levels in control mice. In vaccinated mice, the IgG/IgA antibody levels reactive to S. mitis serotype 5 or S. pneumoniae serotype 5 were higher than the levels reactive to S. pneumoniae serotype 4. Furthermore, in-vitro restimulation of the lung-draining mediastinal lymph node cells and splenocytes from immunized mice with killed S. mitis serotype 5, S. pneumoniae serotype 5 or S. pneumoniae serotype 4 showed enhanced Th17, but not Th1 and Th2, responses. Overall, our findings show that mucosal immunization with S. mitis serotype 5 protects against S. pneumoniae serotype 5 infection and induces Th17 and predominant serotype-specific IgG/IgA antibody responses against pneumococcal infection.

scholarly journals Deep Neck Infection Caused by Eikenella Corrodens Coinfection with Streptococcus Mitis and Streptococcus Oralis in an Infant

2016 ◽  
Author(s):  
Nurhayat YAKUT ◽  
Eda KEPENEKLİ KADAYIFÇI ◽  
Ayşe KARAASLAN ◽  
Serkan ATICI ◽  
Gülşen AKKOÇ ◽  
...  
Keyword(s):  
Deep Neck Infection ◽  
Streptococcus Mitis ◽  
Eikenella Corrodens ◽  
Neck Infection ◽  
Streptococcus Oralis

scholarly journals Viridans Group Streptococci Are Donors in Horizontal Transfer of Topoisomerase IV Genes to Streptococcus pneumoniae

2003 ◽  
Vol 47 (7) ◽  
pp. 2072-2081 ◽  
Author(s):  
Luz Balsalobre ◽  
María José Ferrándiz ◽  
Josefina Liñares ◽  
Fe Tubau ◽  
Adela G. de la Campa
Keyword(s):  
Streptococcus Pneumoniae ◽  
Nucleotide Sequence ◽  
Horizontal Transfer ◽  
Southern Blot Analysis ◽  
Fluoroquinolone Resistance ◽  
Topoisomerase Iv ◽  
Streptococcus Mitis ◽  
Streptococcus Oralis ◽  
Viridans Group Streptococci ◽  
Interspecific Recombination

ABSTRACT A total of 46 ciprofloxacin-resistant (Cipr) Streptococcus pneumoniae strains were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed unexpectedly high rates of nucleotide variations in the quinolone resistance-determining regions (QRDRs) of their parC, parE, and gyrA genes. The nucleotide sequence of the full-length parC, parE, and gyrA genes of one of these isolates revealed a mosaic structure compatible with an interspecific recombination origin. Southern blot analysis and nucleotide sequence determinations showed the presence of an ant-like gene in the intergenic parE-parC regions of the S. pneumoniae Cipr isolates with high rates of variations in their parE and parC QRDRs. The ant-like gene was absent from typical S. pneumoniae strains, whereas it was present in the intergenic parE-parC regions of the viridans group streptococci (Streptococcus mitis and Streptococcus oralis). These results suggest that the viridans group streptococci are acting as donors in the horizontal transfer of fluoroquinolone resistance genes to S. pneumoniae.

scholarly journals Population Diversity and Dynamics of Streptococcus mitis, Streptococcus oralis, and Streptococcus infantis in the Upper Respiratory Tracts of Adults, Determined by a Nonculture Strategy

2008 ◽  
Vol 76 (5) ◽  
pp. 1889-1896 ◽  
Author(s):  
Malene Bek-Thomsen ◽  
Hervé Tettelin ◽  
Ioana Hance ◽  
Karen E. Nelson ◽  
Mogens Kilian
Keyword(s):  
Clonal Diversity ◽  
Housekeeping Gene ◽  
Culture Technique ◽  
Population Diversity ◽  
Ecological Niches ◽  
Upper Respiratory Tract ◽  
Streptococcus Mitis ◽  
Streptococcus Oralis ◽  
Upper Respiratory ◽  
Species Specific

ABSTRACT We reinvestigated the clonal diversity and dynamics of Streptococcus mitis and two other abundant members of the commensal microbiota of the upper respiratory tract, Streptococcus oralis and Streptococcus infantis, to obtain information about the origin of frequently emerging clones in this habitat. A culture-independent method was used, based on cloning and sequencing of PCR amplicons of the housekeeping gene gdh, which shows remarkable, yet species-specific, genetic polymorphism. Samples were collected from all potential ecological niches in the oral cavity and pharynx of two adults on two occasions separated by 2 years. Based on analysis of close to 10,000 sequences, significant diversity was observed in populations of all three species. Fluctuations in the relative proportions of individual clones and species were observed over time. While a few clones dominated, the proportions of most clones were very small. The results show that the frequent turnover of S. mitis, S. oralis, and S. infantis clones observed by cultivation can be explained by fluctuations in the relative proportions of clones, most of which are below the level of detection by the traditional culture technique, possibly combined with loss and acquisition from contacts. These findings provide a platform for understanding the mechanisms that govern the balance within the complex microbiota at mucosal sites and between the microbiota and the mucosal immune system of the host.

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