scholarly journals A Novel Iron Transporter SPD_1590 in Streptococcus pneumoniae Contributing to Bacterial Virulence Properties

2018 ◽  
Vol 9 ◽  
Author(s):  
Xinyu Miao ◽  
Jiaojiao He ◽  
Liang Zhang ◽  
Xinlu Zhao ◽  
Ruiguang Ge ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Bacterial Virulence ◽  
Iron Transporter ◽  
Virulence Properties

scholarly journals Mice Naturally Resistant to Yersinia pestis Δpgm Strains Commonly Used in Pathogenicity Studies

2006 ◽  
Vol 74 (11) ◽  
pp. 6501-6504 ◽  
Author(s):  
Yasemin H. K. Congleton ◽  
Christine R. Wulff ◽  
Edward J. Kerschen ◽  
Susan C. Straley
Keyword(s):  
Yersinia Pestis ◽  
Mouse Strain ◽  
Host Resistance ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Bacterial Virulence ◽  
Powerful System ◽  
Virulence Properties ◽  
Resistance Traits

ABSTRACT We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Δpgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.

Anti-virulence activities of some Tillandsia species (Bromeliaceae)

2020 ◽  
Vol 98 (1) ◽  
pp. 117-127
Author(s):  
Macrina Pérez-López ◽  
María Flores-Cruz ◽  
Mariano Martínez-Vázquez ◽  
Ramón Marcos Soto Hernández ◽  
Rodolfo García-Contreras ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Phenolic Compounds ◽  
Virulence Factors ◽  
Biofilm Formation ◽  
Bacterial Virulence ◽  
Induce Resistance ◽  
Violacein Production ◽  
Potential Strategy ◽  
Total Diversity ◽  
Virulence Properties

Background: Using molecules that inhibit bacterial virulence is a potential strategy to fight infections, with the advantage that, in contrast to bactericidal compounds, they do not induce resistance. Several compounds with anti-virulence properties have been identified in plants, however, they represent a small portion of the total diversity, and in Mexico there are still few studies on this matter.  Hypothesis: Extracts of species of the Tillandsia genus inhibit the expression of diverse virulence factors without affecting the bacterial growth.  Studied species: Tillandsia recurvata (L.) L., T. schiedeana Steud. and T. fasciculata Sw.  Study site and date: These species were collected in December 2016 in the municipalities of Ixtlahuaca and Santo Tomás de los Plátanos, State of Mexico. Methods: The ability of dichloromethane (CH2Cl2) and methanol (CH3OH) extracts to inhibit production of violacein in Chromobacterium violaceum was evaluated, as well as the virulence factors regulated by quorum sensing, motility and biofilm in Pseudomonas aeruginosa. In addition, the bioactive fractions obtained were partially identified by 1H NMR. Results: CH2Cl2 and CH3OH extracts reduced violacein production from 43 to 85 %, but only those from CH2Cl2 reduced protease activity, biofilm formation and swarming. Interestingly, CH3OH extracts stimulated the formation of biofilms by up to 37 %. Presence of terpenes and phenolic compounds in these species was confirmed. In T. schiedeana glycosylated compounds and cycloartane-type triterpenes were identified. Conclusion: The species of Tillandsia show anti-virulence activity, mainly on factors related to adhesion and dispersion in Pseudomonas aeruginosa.

scholarly journals Survival and growth of Stenotrophomonas maltophilia in free-living amoebae (FLA) and bacterial virulence properties

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192308 ◽  
Author(s):  
Elodie Denet ◽  
Valentin Vasselon ◽  
Béatrice Burdin ◽  
Sylvie Nazaret ◽  
Sabine Favre-Bonté
Keyword(s):  
Stenotrophomonas Maltophilia ◽  
Bacterial Virulence ◽  
Free Living ◽  
Survival And Growth ◽  
Virulence Properties

scholarly journals Host Response and Bacterial Virulence Factor Expression in Pseudomonas aeruginosa and Streptococcus pneumoniae Corneal Ulcers

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e64867 ◽  
Author(s):  
Rajapandian SivaGanesa Karthikeyan ◽  
Jeganathan Lakshmi Priya ◽  
Sixto M. Leal ◽  
Jonida Toska ◽  
Arne Rietsch ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Streptococcus Pneumoniae ◽  
Virulence Factor ◽  
Host Response ◽  
Bacterial Virulence ◽  
Corneal Ulcers ◽  
Factor Expression ◽  
Bacterial Virulence Factor

scholarly journals Cortex Cercis chinensis Granules Attenuate Streptococcus pneumoniae Virulence by Targeting Pneumolysin

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yan Xu ◽  
Yanbo Wang ◽  
Yinan Guo ◽  
Lina Wei ◽  
Lizhong Ding ◽  
...  
Keyword(s):  
Cell Death ◽  
Antibacterial Activity ◽  
Streptococcus Pneumoniae ◽  
Chinese Medicine ◽  
A549 Cell ◽  
Animal Experiments ◽  
Vital Role ◽  
Bacterial Virulence ◽  
Promising Target ◽  
Novel Strategy

Pore-forming toxins produced by bacteria are some of the most important molecular weapons for bacterial virulence. Pneumolysin (PLY) is a pore-forming toxin secreted by Streptococcus pneumoniae (S. pneumoniae) and plays a vital role in the spread, colonization, and invasion of this bacterium in the host, indicating that PLY is a promising target for developing treatments against S. pneumoniae infection. In this study, Cortex Cercis chinensis granules (CCCGs), a prescription drug on the market, were shown to inhibit the pore-forming activity of PLY and protect against PLY-mediated cell hemolysis and A549 cell death without antibacterial activity or inhibition of PLY production. In addition, CCCG treatment inhibited the oligomerization of PLY. Animal experiments showed that CCCGs can reduce the death of mice infected with S. pneumoniae, the degree of pathological damage to the lungs, and the levels of TNF-α and IL-6 in the lungs. In summary, our results demonstrated that CCCGs, a marketed Chinese medicine, inhibit PLY activity and subsequently attenuate S. pneumoniae virulence, which would offer a novel strategy for fighting S. pneumoniae infection and a new use for CCCGs.

Sign in / Sign up

Export Citation Format

Share Document