scholarly journals Significant Enrichment and Diversity of the Staphylococcal Arginine Catabolic Mobile Element ACME in Staphylococcus epidermidis Isolates From Subgingival Peri-implantitis Sites and Periodontal Pockets

2018 ◽  
Vol 9 ◽  
Author(s):  
Aoife M. O’Connor ◽  
Brenda A. McManus ◽  
Peter M. Kinnevey ◽  
Gráinne I. Brennan ◽  
Tanya E. Fleming ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Mobile Element ◽  
Arginine Catabolic Mobile Element ◽  
Significant Enrichment

scholarly journals Arginine Catabolic Mobile Element Is Associated With Low Antibiotic Resistance and Low Pathogenicity in Staphylococcus epidermidis From Neonates

2010 ◽  
Vol 68 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Hildegunn N Granslo ◽  
Claus Klingenberg ◽  
Elizabeth G A Fredheim ◽  
Arild Rønnestad ◽  
Tom E Mollnes ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Staphylococcus Epidermidis ◽  
Mobile Element ◽  
Arginine Catabolic Mobile Element

scholarly journals High prevalence of the arginine catabolic mobile element in carriage isolates of methicillin-resistant Staphylococcus epidermidis

2010 ◽  
Vol 66 (1) ◽  
pp. 29-36 ◽  
Author(s):  
François Barbier ◽  
David Lebeaux ◽  
David Hernandez ◽  
Anne-Sophie Delannoy ◽  
Valérie Caro ◽  
...  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Mobile Element ◽  
Methicillin Resistant ◽  
Arginine Catabolic Mobile Element ◽  
High Prevalence

scholarly journals Characterization of a Novel Arginine Catabolic Mobile Element (ACME) and Staphylococcal Chromosomal CassettemecComposite Island with Significant Homology to Staphylococcus epidermidis ACME Type II in Methicillin-Resistant Staphylococcus aureus Genotype ST22-MRSA-IV

2011 ◽  
Vol 55 (5) ◽  
pp. 1896-1905 ◽  
Author(s):  
Anna C. Shore ◽  
Angela S. Rossney ◽  
Orla M. Brennan ◽  
Peter M. Kinnevey ◽  
Hilary Humphreys ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Staphylococcus Epidermidis ◽  
Mobile Element ◽  
Type I ◽  
Type Ii ◽  
Coagulase Negative Staphylococci ◽  
Methicillin Resistant ◽  
Content Type ◽  
Arginine Catabolic Mobile Element

ABSTRACTThe arginine catabolic mobile element (ACME) is prevalent among methicillin-resistantStaphylococcus aureus(MRSA) isolates of sequence type 8 (ST8) and staphylococcal chromosomal cassettemec(SCCmec) type IVa (USA300) (ST8-MRSA-IVa isolates), and evidence suggests that ACME enhances the ability of ST8-MRSA-IVa to grow and survive on its host. ACME has been identified in a small number of isolates belonging to other MRSA clones but is widespread among coagulase-negative staphylococci (CoNS). This study reports the first description of ACME in two distinct strains of the pandemic ST22-MRSA-IV clone. A total of 238 MRSA isolates recovered in Ireland between 1971 and 2008 were investigated for ACME using a DNA microarray. Twenty-three isolates (9.7%) were ACME positive, and all were either MRSA genotype ST8-MRSA-IVa (7/23, 30%) or MRSA genotype ST22-MRSA-IV (16/23, 70%). Whole-genome sequencing and comprehensive molecular characterization revealed the presence of a novel 46-kb ACME and staphylococcal chromosomal cassettemec(SCCmec) composite island (ACME/SCCmec-CI) in ST22-MRSA-IVh isolates (n= 15). This ACME/SCCmec-CI consists of a 12-kb DNA region previously identified in ACME type II inS. epidermidisATCC 12228, a truncated copy of the J1 region of SCCmectype I, and a complete SCCmectype IVh element. The composite island has a novel genetic organization, with ACME located withinorfXand SCCmeclocated downstream of ACME. One PVL locus-positive ST22-MRSA-IVa isolate carried ACME located downstream of SCCmectype IVa, as previously described in ST8-MRSA-IVa. These results suggest that ACME has been acquired by ST22-MRSA-IV on two independent occasions. At least one of these instances may have involved horizontal transfer and recombination events between MRSA and CoNS. The presence of ACME may enhance dissemination of ST22-MRSA-IV, an already successful MRSA clone.

scholarly journals Genetic Diversity of Arginine Catabolic Mobile Element in Staphylococcus epidermidis

PLoS ONE ◽  
2009 ◽  
Vol 4 (11) ◽  
pp. e7722 ◽  
Author(s):  
Maria Miragaia ◽  
Herminia de Lencastre ◽  
Francoise Perdreau-Remington ◽  
Henry F. Chambers ◽  
Julie Higashi ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Staphylococcus Epidermidis ◽  
Mobile Element ◽  
Arginine Catabolic Mobile Element
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