scholarly journals The SCO4117 ECF Sigma Factor Pleiotropically Controls Secondary Metabolism and Morphogenesis in Streptomyces coelicolor

2018 ◽  
Vol 9 ◽  
Author(s):  
María T. López-García ◽  
Paula Yagüe ◽  
Nathaly González-Quiñónez ◽  
Beatriz Rioseras ◽  
Angel Manteca
Keyword(s):  
Secondary Metabolism ◽  
Sigma Factor ◽  
Streptomyces Coelicolor ◽  
Ecf Sigma Factor

scholarly journals A genomic island of Streptomyces coelicolor with the self-contained regulon of an ECF sigma factor

2018 ◽  
Author(s):  
Camilla M. Kao ◽  
Nitsara Karoonuthaisiri ◽  
David Weaver ◽  
Jonathan A. Vroom ◽  
Shuning A. Gai ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Sigma Factor ◽  
Genomic Island ◽  
Streptomyces Coelicolor ◽  
Sigma Factors ◽  
Genomic Islands ◽  
Biologically Active ◽  
Transcriptional Unit ◽  
Ecf Sigma Factor

AbstractStreptomycetes constitute the largest genus of actinobacteria, living predominantly in soil and decaying vegetation. The bacteria are widely known for their filamentous morphologies and their capacity to synthesize antibiotics and other biologically active molecules. More than a decade ago, we and others identified 22 genomic islands thatStreptomyces coelicolorM145 possesses and otherStreptomycesstrains lack. One of these genomic islands, Genomic Island (GI) 6, encodes an extracytoplasmic function (ECF) sigma factor that we were characterizing in separate work. Here we report that artificial induction of the ECF sigma factor, which is encoded by SCO3450, causes the transcription of approximately one-fourth of GI 6, or ~26 mostly contiguous genes, to increase. More than half of the regulon encodes putative enzymes involved in small molecule metabolism. A putative haloacid dehalogenase is present. Genes encoding two putative anti-sigma factors flank SCO3450, the three genes residing within the regulon. Our data suggest that the ECF sigma factor and its regulon are a self-contained transcriptional unit that can be transferred by horizontal gene transfer. To our knowledge, only one other example has been identified of an ECF sigma factor and its contiguous regulon appearing to be transferrable by horizontal gene transfer [18,19]. Because the regulon appears not to be induced by the 44 growth conditions recently examined by Byung-Kwan Cho and colleagues [20], if it confers fitness toS. coelicolor, the regulon likely does so in as-yet unknown situations. Those situations might range from scavenging to detoxification to even communication within microbial communities.IMPORTANCEStreptomycesbacteria grow as hyphae that colonize soil and differentiate into spores when nutrients become scarce. In their terrestrial habitats, the bacteria encounter diverse conditions. Presumably so that the bacteria can cope with those conditions, the chromosomes of streptomycetes are highly dynamic, varying greatly in structure not only between species but also between closely related strains of a single species. The bacteria also have large numbers of extracytoplasmic function (ECF) sigma factors, which undoubtedly help the microorganisms respond to the plethora of challenges coming from the environment. This work illustrates these two threads ofStreptomycesbiology dovetailing: Genetic adaptability through horizontal gene transfer seems to have enabledStreptomyces coelicolorto acquire a self-contained transcriptional unit that consists of an ECF sigma factor and its regulon. The suggested facile movement of the regulon between microbial hosts indicates the value of the metabolism of small molecules possibly mediated by the regulon.

Regulation of the FecI-type ECF sigma factor by transmembrane signalling

2003 ◽  
Vol 6 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Volkmar Braun ◽  
Susanne Mahren ◽  
Monica Ogierman
Keyword(s):  
Sigma Factor ◽  
Transmembrane Signalling ◽  
Ecf Sigma Factor

The ECF sigma factor σTis involved in osmotic and oxidative stress responses in Caulobacter crescentus

2007 ◽  
Vol 66 (5) ◽  
pp. 1240-1255 ◽  
Author(s):  
Cristina E. Alvarez-Martinez ◽  
Rogério F. Lourenço ◽  
Regina L. Baldini ◽  
Michael T. Laub ◽  
Suely L. Gomes
Keyword(s):  
Oxidative Stress ◽  
Stress Responses ◽  
Sigma Factor ◽  
Caulobacter Crescentus ◽  
Ecf Sigma Factor ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress

Haemophore-mediated signalling in Serratia marcescens: a new mode of regulation for an extra cytoplasmic function (ECF) sigma factor involved in haem acquisition

2004 ◽  
Vol 53 (4) ◽  
pp. 1267-1277 ◽  
Author(s):  
Francis Biville ◽  
Hélène Cwerman ◽  
Sylvie Létoffé ◽  
Maria-Silvia Rossi ◽  
Valérie Drouet ◽  
...  
Keyword(s):  
Serratia Marcescens ◽  
Sigma Factor ◽  
Ecf Sigma Factor ◽  
Mode Of Regulation
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