scholarly journals The Promise of Systems Biology Approaches for Revealing Host Pathogen Interactions in Malaria

2017 ◽  
Vol 8 ◽  
Author(s):  
Meghan Zuck ◽  
Laura S. Austin ◽  
Samuel A. Danziger ◽  
John D. Aitchison ◽  
Alexis Kaushansky
Keyword(s):  
Systems Biology ◽  
Host Pathogen Interactions ◽  
Host Pathogen

Uncovering complex molecular networks in host–pathogen interactions using systems biology

2019 ◽  
Vol 3 (4) ◽  
pp. 371-378
Author(s):  
Joshua M. Peters ◽  
Sydney L. Solomon ◽  
Christopher Y. Itoh ◽  
Bryan D. Bryson
Keyword(s):  
Systems Biology ◽  
High Throughput ◽  
Cell Biology ◽  
Molecular Networks ◽  
Host Pathogen Interactions ◽  
Exciting Field ◽  
Specific Host ◽  
Biomolecular Network ◽  
Host Pathogen ◽  
Analytical Frameworks

Abstract Interactions between pathogens and their hosts can induce complex changes in both host and pathogen states to privilege pathogen survival or host clearance of the pathogen. To determine the consequences of specific host–pathogen interactions, a variety of techniques in microbiology, cell biology, and immunology are available to researchers. Systems biology that enables unbiased measurements of transcriptomes, proteomes, and other biomolecules has become increasingly common in the study of host–pathogen interactions. These approaches can be used to generate novel hypotheses or to characterize the effects of particular perturbations across an entire biomolecular network. With proper experimental design and complementary data analysis tools, high-throughput omics techniques can provide novel insights into the mechanisms that underlie processes from phagocytosis to pathogen immune evasion. Here, we provide an overview of the suite of biochemical approaches for high-throughput analyses of host–pathogen interactions, analytical frameworks for understanding the resulting datasets, and a vision for the future of this exciting field.

Using a Systems Biology Approach To Study Host-Pathogen Interactions

2020 ◽  
pp. 337-347
Author(s):  
Amy Yeung ◽  
Christine Hale ◽  
Simon Clare ◽  
Sophie Palmer ◽  
Josefin Bartholdson Scott ◽  
...  
Keyword(s):  
Systems Biology ◽  
Host Pathogen Interactions ◽  
Host Pathogen

scholarly journals On the road to systems biology of host–pathogen interactions

2010 ◽  
Vol 5 (2) ◽  
pp. 131-133 ◽  
Author(s):  
Klaus Früh ◽  
Brett Finlay ◽  
Grant McFadden
Keyword(s):  
Systems Biology ◽  
Host Pathogen Interactions ◽  
The Road ◽  
Host Pathogen ◽  
On The Road

Using a Systems Biology Approach To Study Host-Pathogen Interactions

2019 ◽  
pp. 349-356 ◽  
Author(s):  
Amy Yeung ◽  
Christine Hale ◽  
Simon Clare ◽  
Sophie Palmer ◽  
Josefin Bartholdson Scott ◽  
...  
Keyword(s):  
Systems Biology ◽  
Host Pathogen Interactions ◽  
Host Pathogen

Spatiotemporal Structure of Host-Pathogen Interactions in a Metapopulation

2009 ◽  
Vol 174 (3) ◽  
pp. 308
Author(s):  
Soubeyrand ◽  
Laine ◽  
Hanski ◽  
Penttinen
Keyword(s):  
Host Pathogen Interactions ◽  
Spatiotemporal Structure ◽  
Host Pathogen

scholarly journals Porcine small intestinal organoids as a model to explore ETEC–host interactions in the gut

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Bjarne Vermeire ◽  
Liara M. Gonzalez ◽  
Robert J. J. Jansens ◽  
Eric Cox ◽  
Bert Devriendt
Keyword(s):  
Intestinal Epithelial ◽  
Gut Health ◽  
Functional Responses ◽  
Host Pathogen Interactions ◽  
Epithelial Surface ◽  
Host Interactions ◽  
Intestinal Organoids ◽  
Host Pathogen ◽  
Small Intestinal

AbstractSmall intestinal organoids, or enteroids, represent a valuable model to study host–pathogen interactions at the intestinal epithelial surface. Much research has been done on murine and human enteroids, however only a handful studies evaluated the development of enteroids in other species. Porcine enteroid cultures have been described, but little is known about their functional responses to specific pathogens or their associated virulence factors. Here, we report that porcine enteroids respond in a similar manner as in vivo gut tissues to enterotoxins derived from enterotoxigenic Escherichia coli, an enteric pathogen causing postweaning diarrhoea in piglets. Upon enterotoxin stimulation, these enteroids not only display a dysregulated electrolyte and water balance as shown by their swelling, but also secrete inflammation markers. Porcine enteroids grown as a 2D-monolayer supported the adhesion of an F4+ ETEC strain. Hence, these enteroids closely mimic in vivo intestinal epithelial responses to gut pathogens and are a promising model to study host–pathogen interactions in the pig gut. Insights obtained with this model might accelerate the design of veterinary therapeutics aimed at improving gut health.

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