scholarly journals Prebiotic and Synbiotic Modifications of Beta Oxidation and Lipogenic Gene Expression after Experimental Hypercholesterolemia in Rat Liver

2017 ◽  
Vol 8 ◽  
Author(s):  
Claudia C. Alves ◽  
Dan L. Waitzberg ◽  
Laila S. de Andrade ◽  
Laís dos Santos Aguiar ◽  
Milene B. Reis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
Beta Oxidation ◽  
Lipogenic Gene ◽  
Lipogenic Gene Expression ◽  
Experimental Hypercholesterolemia

scholarly journals Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1

2010 ◽  
Vol 432 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Aldo Grefhorst ◽  
Marijke Schreurs ◽  
Maaike H. Oosterveer ◽  
Victor A. Cortés ◽  
Rick Havinga ◽  
...  
Keyword(s):  
Gene Expression ◽  
Binding Protein ◽  
Glycogen Storage Disease Type ◽  
Glycogen Storage ◽  
Hepatic Glycogen ◽  
Lipogenic Gene ◽  
Lipogenic Gene Expression ◽  
Liver X Receptor Α ◽  
Element Binding Protein

GSD-1 (glycogen storage disease type 1) is caused by an inherited defect in glucose-6-phosphatase activity, resulting in a massive accumulation of hepatic glycogen content and an induction of de novo lipogenesis. The chlorogenic acid derivative S4048 is a pharmacological inhibitor of the glucose 6-phosphate transporter, which is part of glucose-6-phosphatase, and allows for mechanistic studies concerning metabolic defects in GSD-1. Treatment of mice with S4048 resulted in an ~60% reduction in blood glucose, increased hepatic glycogen and triacylglycerol (triglyceride) content, and a markedly enhanced hepatic lipogenic gene expression. In mammals, hepatic expression of lipogenic genes is regulated by the co-ordinated action of the transcription factors SREBP (sterol-regulatory-element-binding protein)-1c, LXRα (liver X receptor α) and ChREBP (carbohydrate-response-element-binding protein). Treatment of Lxra−/− mice and Chrebp−/− mice with S4048 demonstrated that ChREBP, but not LXRα, mediates the induction of hepatic lipogenic gene expression in this murine model of GSD-1. Thus ChREBP is an attractive target to alleviate derangements in lipid metabolism observed in patients with GSD-1.

High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling

2021 ◽  
Author(s):  
De Xie ◽  
Hairong Zhao ◽  
Jiaming Lu ◽  
Furong He ◽  
Weidong Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Uric Acid ◽  
Fatty Acid Synthase ◽  
Specific Inhibitor ◽  
Urate Oxidase ◽  
Alcoholic Fatty Liver ◽  
Fat Accumulation ◽  
Lipogenic Gene ◽  
Lipogenic Gene Expression ◽  
Jnk Activation

Uric acid is the end metabolite derived from the oxidation of purine compounds. Overwhelming evidence shows the vital interrelation between hyperuricemia (HUA) and non-alcoholic fatty liver disease (NAFLD). However, the mechanisms for this association remain unclear. In this study, we investigated the effect of HUA on fat accumulation in human HepG2 hepatoma cells and urate oxidase-knockout (Uox-KO) mice. HUA activated c-Jun N-terminal kinase (JNK) in vivo and in vitro. Furthermore, inhibiting JNK activation by a JNK-specific inhibitor, SP600125, decreased fat accumulation and lipogenic gene expression induced by HUA. Overexpression of the lipogenic enzymes fatty acid synthase and acetyl-CoA carboxylase 1 was via activation of JNK, which was blocked by the JNK inhibitor SP600125. HUA activated AP-1 to upregulate lipogenic gene expression via JNK activation. In addition, HUA caused mitochondrial dysfunction and reactive oxygen species production. Pre-treatment with the antioxidant N-acetyl-L-cysteine could ameliorate HUA-activated JNK and hepatic steatosis. These data suggest that ROS/JNK/AP-1 signaling plays an important role in HUA-mediated fat accumulation in liver.

scholarly journals Dietary trans Fatty Acid Isomers Differ in Their Effects on Mammary Lipid Metabolism As Well As Lipogenic Gene Expression in Lactating Mice

2010 ◽  
Vol 140 (5) ◽  
pp. 919-924 ◽  
Author(s):  
Anil K. G. Kadegowda ◽  
Erin E. Connor ◽  
Beverly B. Teter ◽  
Joseph Sampugna ◽  
Pierluigi Delmonte ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Trans Fatty Acid ◽  
Lipogenic Gene ◽  
Lipogenic Gene Expression ◽  
Trans Fatty Acid Isomers
Sign in / Sign up

Export Citation Format

Share Document