scholarly journals Melatonin Reduces Oxidative Stress Damage Induced by Hydrogen Peroxide in Saccharomyces cerevisiae

2017 ◽  
Vol 8 ◽  
Author(s):  
Jennifer Vázquez ◽  
Beatriz González ◽  
Verónica Sempere ◽  
Albert Mas ◽  
María Jesús Torija ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Hydrogen Peroxide ◽  
Stress Damage

Idebenone Treatment Mediates the Effect of Menadione Oxidative Stress Damage in Saccharomyces cerevisiae

2012 ◽  
Vol 6 (2) ◽  
pp. 120-123 ◽  
Author(s):  
Oliver Gamondi ◽  
Sebastian Chapela ◽  
Ines Nievas ◽  
Isabel Burgos ◽  
Manuel Alonso ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Stress Damage

scholarly journals 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

2014 ◽  
Vol 15 (3) ◽  
pp. 4608-4618 ◽  
Author(s):  
Chi-I Chang ◽  
Wan-Chiao Hu ◽  
Che-Piao Shen ◽  
Ban-Dar Hsu ◽  
Wei-Yong Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Stress Damage

Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways

Life Sciences ◽  
2015 ◽  
Vol 130 ◽  
pp. 38-46 ◽  
Author(s):  
Xiaolong Hou ◽  
Qing Tong ◽  
Wenqing Wang ◽  
Wei Xiong ◽  
Chunyang Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Endothelial Cells ◽  
Stress Damage

Dehydroepiandrosterone rehabilitate BRL-3A cells oxidative stress damage induced by hydrogen peroxide

2018 ◽  
Vol 233 (8) ◽  
pp. 6262-6272 ◽  
Author(s):  
Longlong Li ◽  
Jinlong Zhao ◽  
Chongyang Ge ◽  
Lei Yu ◽  
Haitian Ma
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Stress Damage

scholarly journals Protective Effects and Mechanism of Hyperoside in PC12 Cells Against Oxidative Stress Injury Induced by Hydrogen Peroxide

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110151
Author(s):  
Yan Feng ◽  
Dongxu Wang ◽  
Qi Wang ◽  
Zhifeng Li ◽  
Shi-Lin Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Neurodegenerative Diseases ◽  
Pc12 Cells ◽  
Neuronal Damage ◽  
Neuroprotective Effect ◽  
Natural Antioxidants ◽  
Protective Effects ◽  
Stress Injury ◽  
Stress Damage

As the aging phenomenon continues to increase, the incidence of neurodegenerative diseases continues to increase annually. As one of the significant contributive factors of neurodegenerative diseases, oxidative stress damage has received extensive attention in recent years. Oxidative stress plays an important role in neuronal damage through various apoptotic mechanisms related to neurodegenerative diseases. The use of natural antioxidants to combat oxidative stress may be a useful approach in delaying disease progression. In this study, we explored the neuroprotective effect of hyperoside on rat pheochromoma (PC12) cells. Specifically, the antioxidant effect and mechanism of hyperoside in hydrogen peroxide (H2O2)-induced cellular cytotoxicity were investigated. Our results showed that hyperoside could significantly increase the survival rate of rat PC12 cells when exposed to H2O2. In addition, hyperoside regulated the expression of genes and proteins in the corresponding pathways by up-regulating the phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), and light chain 3β (LC3B) pathways and down-regulating the nuclear factor-ᴋ-gene binding (NF-κB), Bcl2-associated X (Bax), cysteinyl aspartate specific proteinase 3 (Caspase 3), and P62 pathways, thereby inhibiting cell apoptosis. Therefore, hyperoside can effectively inhibit H2O2-induced oxidative stress damage by regulating inflammation, autophagy, and apoptosis-related pathways.

scholarly journals Conjugation with Methylsulfonylmethane Improves Hyaluronic Acid Anti-Inflammatory Activity in a Hydrogen Peroxide-Exposed Tenocyte Culture In Vitro Model

2020 ◽  
Vol 21 (21) ◽  
pp. 7956
Author(s):  
Francesco Oliva ◽  
Marialucia Gallorini ◽  
Cristina Antonetti Lamorgese Passeri ◽  
Clarissa Gissi ◽  
Alessia Ricci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Hyaluronic Acid ◽  
Rotator Cuff ◽  
Tendon Healing ◽  
Rotator Cuff Tears ◽  
Collagen Iii ◽  
Anti Inflammatory ◽  
Stress Damage

Rotator cuff tears (RCTs) and rotator cuff disease (RCD) are important causes of disability in middle-aged individuals affected by nontraumatic shoulder dysfunctions. Our previous studies have demonstrated that four different hyaluronic acid preparations (HAPs), including Artrosulfur® hyaluronic acid (HA) (Alfakjn S.r.l., Garlasco, Italy), may exert a protective effect in human RCT-derived tendon cells undergoing oxidative stress damage. Recently, methylsulfonylmethane (MSM) (Barentz, Paderno Dugnano, Italy) has proven to have anti-inflammatory properties and to cause pain relief in patients affected by tendinopathies. This study aims at evaluating three preparations (Artrosulfur® HA, MSM, and Artrosulfur® MSM + HA) in the recovery from hydrogen peroxide-induced oxidative stress damage in human tenocyte. Cell proliferation, Lactate Dehydrogenase (LDH) release, and inducible nitric oxide synthases (iNOS) and prostaglandin E2 (PGE2) modulation were investigated. In parallel, expression of metalloproteinases 2 (MMP2) and 14 (MMP14) and collagen types I and III were also examined. Results demonstrate that Artrosulfur® MSM + HA improves cell escape from oxidative stress by decreasing cytotoxicity and by reducing iNOS and PGE2 secretion. Furthermore, it differentially modulates MMP2 and MMP14 levels and enhances collagen III expression after 24 h, proteins globally related to rapid acceleration of the extracellular matrix (ECM) remodelling and thus tendon healing. By improving the anti-cytotoxic effect of HA, the supplementation of MSM may represent a feasible strategy to ameliorate cuff tendinopathies.

scholarly journals Antioxidant potential of yerba mate (Ilex paraguariensis St. Hil.) extracts in Saccharomyces cerevisae deficient in oxidant defense genes

2016 ◽  
Vol 76 (2) ◽  
pp. 539-544 ◽  
Author(s):  
A. C. Piovezan-Borges ◽  
C. Valério-Júnior ◽  
I. L. Gonçalves ◽  
A. A. Mielniczki-Pereira ◽  
A. T. Valduga
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Hydrogen Peroxide ◽  
Antioxidant Defense ◽  
New Products ◽  
Antioxidant Potential ◽  
Ilex Paraguariensis ◽  
Yerba Mate ◽  
Aqueous Extracts ◽  
Defense Genes

Abstract Yerba-mate (Ilex paraguariensis St. Hil) is mainly consumed as “chimarrão”, a hot drink highly appreciated in Brazil, Argentina, Paraguay and Uruguay. This study evaluated the antioxidant potential of aqueous extracts of I. paraguariensis precipitated with ethanol. The leaves were processed as for tea product (TM) and oxidized (OX). The antioxidant potential was evaluated in cells of Saccharomyces cerevisiae deficient in antioxidant defense genes. Three strains evaluated were: a wild (EG) and two mutants (ctt1Δ e ctt1Δsod1Δ). These strains were pre-treated with the yerba-mate extracts (TM e OX) and submitted to oxidative stress induced by hydrogen peroxide. None of the extracts produced loss of cell viability. The extracts exerted antioxidant activity, protecting the strains (except sod1∆ctt1∆). The TM extract was more effective than OX. I. paraguariensis extracts showed a potential to be explored in the development of new products.

Idebenone Treatment Mediates the Effect of Menadione Oxidative Stress Damage in Saccharomyces cerevisiae

2012 ◽  
Vol 6 (2) ◽  
pp. 120-123
Author(s):  
Oliver Gamondi ◽  
Sebastian Chapela ◽  
Ines Nievas ◽  
Isabel Burgos ◽  
Manuel Alonso ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Stress Damage
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