Dehydroepiandrosterone rehabilitate BRL-3A cells oxidative stress damage induced by hydrogen peroxide

2018 ◽  
Vol 233 (8) ◽  
pp. 6262-6272 ◽  
Author(s):  
Longlong Li ◽  
Jinlong Zhao ◽  
Chongyang Ge ◽  
Lei Yu ◽  
Haitian Ma
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Stress Damage

scholarly journals 8-Alkylcoumarins from the Fruits of Cnidium monnieri Protect against Hydrogen Peroxide Induced Oxidative Stress Damage

2014 ◽  
Vol 15 (3) ◽  
pp. 4608-4618 ◽  
Author(s):  
Chi-I Chang ◽  
Wan-Chiao Hu ◽  
Che-Piao Shen ◽  
Ban-Dar Hsu ◽  
Wei-Yong Lin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Stress Damage

Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways

Life Sciences ◽  
2015 ◽  
Vol 130 ◽  
pp. 38-46 ◽  
Author(s):  
Xiaolong Hou ◽  
Qing Tong ◽  
Wenqing Wang ◽  
Wei Xiong ◽  
Chunyang Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Endothelial Cells ◽  
Stress Damage

scholarly journals Melatonin Reduces Oxidative Stress Damage Induced by Hydrogen Peroxide in Saccharomyces cerevisiae

2017 ◽  
Vol 8 ◽  
Author(s):  
Jennifer Vázquez ◽  
Beatriz González ◽  
Verónica Sempere ◽  
Albert Mas ◽  
María Jesús Torija ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Hydrogen Peroxide ◽  
Stress Damage

scholarly journals Protective Effects and Mechanism of Hyperoside in PC12 Cells Against Oxidative Stress Injury Induced by Hydrogen Peroxide

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110151
Author(s):  
Yan Feng ◽  
Dongxu Wang ◽  
Qi Wang ◽  
Zhifeng Li ◽  
Shi-Lin Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Neurodegenerative Diseases ◽  
Pc12 Cells ◽  
Neuronal Damage ◽  
Neuroprotective Effect ◽  
Natural Antioxidants ◽  
Protective Effects ◽  
Stress Injury ◽  
Stress Damage

As the aging phenomenon continues to increase, the incidence of neurodegenerative diseases continues to increase annually. As one of the significant contributive factors of neurodegenerative diseases, oxidative stress damage has received extensive attention in recent years. Oxidative stress plays an important role in neuronal damage through various apoptotic mechanisms related to neurodegenerative diseases. The use of natural antioxidants to combat oxidative stress may be a useful approach in delaying disease progression. In this study, we explored the neuroprotective effect of hyperoside on rat pheochromoma (PC12) cells. Specifically, the antioxidant effect and mechanism of hyperoside in hydrogen peroxide (H2O2)-induced cellular cytotoxicity were investigated. Our results showed that hyperoside could significantly increase the survival rate of rat PC12 cells when exposed to H2O2. In addition, hyperoside regulated the expression of genes and proteins in the corresponding pathways by up-regulating the phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), and light chain 3β (LC3B) pathways and down-regulating the nuclear factor-ᴋ-gene binding (NF-κB), Bcl2-associated X (Bax), cysteinyl aspartate specific proteinase 3 (Caspase 3), and P62 pathways, thereby inhibiting cell apoptosis. Therefore, hyperoside can effectively inhibit H2O2-induced oxidative stress damage by regulating inflammation, autophagy, and apoptosis-related pathways.

scholarly journals Conjugation with Methylsulfonylmethane Improves Hyaluronic Acid Anti-Inflammatory Activity in a Hydrogen Peroxide-Exposed Tenocyte Culture In Vitro Model

2020 ◽  
Vol 21 (21) ◽  
pp. 7956
Author(s):  
Francesco Oliva ◽  
Marialucia Gallorini ◽  
Cristina Antonetti Lamorgese Passeri ◽  
Clarissa Gissi ◽  
Alessia Ricci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Hyaluronic Acid ◽  
Rotator Cuff ◽  
Tendon Healing ◽  
Rotator Cuff Tears ◽  
Collagen Iii ◽  
Anti Inflammatory ◽  
Stress Damage

Rotator cuff tears (RCTs) and rotator cuff disease (RCD) are important causes of disability in middle-aged individuals affected by nontraumatic shoulder dysfunctions. Our previous studies have demonstrated that four different hyaluronic acid preparations (HAPs), including Artrosulfur® hyaluronic acid (HA) (Alfakjn S.r.l., Garlasco, Italy), may exert a protective effect in human RCT-derived tendon cells undergoing oxidative stress damage. Recently, methylsulfonylmethane (MSM) (Barentz, Paderno Dugnano, Italy) has proven to have anti-inflammatory properties and to cause pain relief in patients affected by tendinopathies. This study aims at evaluating three preparations (Artrosulfur® HA, MSM, and Artrosulfur® MSM + HA) in the recovery from hydrogen peroxide-induced oxidative stress damage in human tenocyte. Cell proliferation, Lactate Dehydrogenase (LDH) release, and inducible nitric oxide synthases (iNOS) and prostaglandin E2 (PGE2) modulation were investigated. In parallel, expression of metalloproteinases 2 (MMP2) and 14 (MMP14) and collagen types I and III were also examined. Results demonstrate that Artrosulfur® MSM + HA improves cell escape from oxidative stress by decreasing cytotoxicity and by reducing iNOS and PGE2 secretion. Furthermore, it differentially modulates MMP2 and MMP14 levels and enhances collagen III expression after 24 h, proteins globally related to rapid acceleration of the extracellular matrix (ECM) remodelling and thus tendon healing. By improving the anti-cytotoxic effect of HA, the supplementation of MSM may represent a feasible strategy to ameliorate cuff tendinopathies.

scholarly journals Cordyceps Militaris Carotenoids Protect ARPE-19 Cells From Oxidative Stress Damage Induced By Hydrogen Peroxide

2021 ◽  
Author(s):  
Lin Lan ◽  
YuZhi Ren ◽  
XiangYu Zhou ◽  
ShengYu Wang ◽  
JinSen Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Protein Expression ◽  
Macular Degeneration ◽  
Retinal Pigment ◽  
Cordyceps Militaris ◽  
Retinal Pigment Epithelial Cells ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Stress Damage

Abstract A retinal disorder known as age-related macular degeneration (AMD) can be very damaging, which may result in vision loss. Cordyceps militaris has antioxidant, anti-inflammatory, anticancer activity and immunomodulatory functions. carotenoids were considered potential therapeutic agents for the treatment of age-related macular degeneration. In this study, we evaluated for the first time the protective effect of purified carotenoids (CMCT) extracted from Cordyceps militaris on hydrogen peroxide (H2O2)-induced damage to human retinal pigment epithelial cells (ARPE-19). The pretreatment of ARPE-19 cells with CMCT (1, 2.5μg/ml) for 12h after exposure to H2O2 (400μM) greatly improved cell viability and injury tolerance. and reduced reactive oxygen species production (ROS) and decreased malondialdehyde (MDA) formation. Furthermore, Bax and Caspase-3 showed increased protein expression and less protein expression of Bcl-2 in cellular oxidative stress by flow cytometry analysis but showed the opposite expression by adding CMCT. Besides, cells were treated with H2O2 and then CMCT restored catalase (CAT), superoxide dismutase (SOD) and glutathione (GSH) enzyme activities to normal levels. Our results suggest that CMCT can protect RPE cells from oxidative stress damage by regulating oxidative activity and anti-apoptotic function. It indicates that CMCT has a potential therapeutic role in oxidative stress-directed protection and prevention of AMD.

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