scholarly journals The Fungal Pathogen Candida glabrata Does Not Depend on Surface Ferric Reductases for Iron Acquisition

2017 ◽  
Vol 8 ◽  
Author(s):  
Franziska Gerwien ◽  
Abu Safyan ◽  
Stephanie Wisgott ◽  
Sascha Brunke ◽  
Lydia Kasper ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Iron Acquisition ◽  
Ferric Reductases

scholarly journals Candida albicans Ferric Reductases Are Differentially Regulated in Response to Distinct Forms of Iron Limitation by the Rim101 and CBF Transcription Factors

2008 ◽  
Vol 7 (7) ◽  
pp. 1168-1179 ◽  
Author(s):  
Yong-Un Baek ◽  
Mingchun Li ◽  
Dana A. Davis
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Candida Albicans ◽  
Transcription Factors ◽  
Iron Acquisition ◽  
Mammalian Host ◽  
Regulatory Sequence ◽  
Ferric Reductase ◽  
Reductase Gene ◽  
Ferric Reductases

ABSTRACT Iron is an essential nutrient that is severely limited in the mammalian host. Candida albicans encodes a family of 15 putative ferric reductases, which are required for iron acquisition and utilization. Despite the central role of ferric reductases in iron acquisition and mobilization, relatively little is known about the regulatory networks that govern ferric reductase gene expression in C. albicans. Here we have demonstrated the differential regulation of two ferric reductases, FRE2 and FRP1, in response to distinct iron-limited environments. FRE2 and FRP1 are both induced in alkaline-pH environments directly by the Rim101 transcription factor. However, FRP1 but not FRE2 is also induced by iron chelation. We have identified a CCAAT motif as the critical regulatory sequence for chelator-mediated induction and have found that the CCAAT binding factor (CBF) is essential for FRP1 expression in iron-limited environments. We found that a hap5Δ/hap5Δ mutant, which disrupts the core DNA binding activity of CBF, is unable to grow under iron-limited conditions. C. albicans encodes three CBF-dependent transcription factors, and we identified the Hap43 protein as the CBF-dependent transcription factor required for iron-limited responses. These studies provide key insights into the regulation of ferric reductase gene expression in the fungal pathogen C. albicans.

scholarly journals Jjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata

mSphere ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Sarah G. Whaley ◽  
Kelly E. Caudle ◽  
Lucia Simonicova ◽  
Qing Zhang ◽  
W. Scott Moye-Rowley ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Antifungal Agents ◽  
Common Species ◽  
Negative Regulator ◽  
Gene Encoding ◽  
Fluconazole Resistance ◽  
Mechanism Of Resistance ◽  
Primary Mechanism ◽  
Activating Mutation

Candida glabrata is the second most common species of Candida recovered from patients with invasive candidiasis. The increasing number of infections due to C. glabrata, combined with its high rates of resistance to the commonly used, well-tolerated azole class of antifungal agents, has limited the use of this antifungal class. This has led to the preferential use of echinocandins as empirical treatment for serious Candida infections. The primary mechanism of resistance found in clinical isolates is the presence of an activating mutation in the gene encoding the transcription factor Pdr1 that results in upregulation of one or more of the efflux pumps Cdr1, Pdh1, and Snq2. By developing a better understanding of this mechanism of resistance to the azoles, it will be possible to develop strategies for reclaiming the utility of the azole antifungals against this important fungal pathogen.

Carbonic anhydrase regulation and CO2 sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog

2013 ◽  
Vol 21 (6) ◽  
pp. 1549-1554 ◽  
Author(s):  
Fabien Cottier ◽  
Worraanong Leewattanapasuk ◽  
Laura R. Kemp ◽  
Mariana Murphy ◽  
Claudiu T. Supuran ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Fungal Pathogen ◽  
Candida Glabrata

scholarly journals Opportunistic fungal pathogen Candida glabrata circulates between humans and yellow-legged gulls

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mohammed Hashim Al-Yasiri ◽  
Anne-Cécile Normand ◽  
Coralie L’Ollivier ◽  
Laurence Lachaud ◽  
Nathalie Bourgeois ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Opportunistic Fungal Pathogen

scholarly journals Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells

mBio ◽  
2021 ◽  
Author(s):  
Rocio Garcia-Rubio ◽  
Cristina Jimenez-Ortigosa ◽  
Lucius DeGregorio ◽  
Christopher Quinteros ◽  
Erika Shor ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Clinical Failure ◽  
First Line ◽  
Content Type ◽  
First Line Therapy ◽  
Line Therapy ◽  
Resistant Strains ◽  
Opportunistic Fungal Pathogen

Echinocandin drugs are a first-line therapy to treat invasive candidiasis, which is a major source of morbidity and mortality worldwide. The opportunistic fungal pathogen Candida glabrata is a prominent bloodstream fungal pathogen, and it is notable for rapidly developing echinocandin-resistant strains associated with clinical failure.

Understand the genomic diversity and evolution of fungal pathogen Candida glabrata by genome-wide analysis of genetic variations

Methods ◽  
2020 ◽  
Vol 176 ◽  
pp. 82-90 ◽  
Author(s):  
Xiaoxian Guo ◽  
Ruoyu Zhang ◽  
Yudong Li ◽  
Zhe Wang ◽  
Olena P. Ishchuk ◽  
...  
Keyword(s):  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Genetic Variations ◽  
Genomic Diversity ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata

2011 ◽  
Vol 4 (1) ◽  
pp. 169-186 ◽  
Author(s):  
Michael Tscherner ◽  
Tobias Schwarzmüller ◽  
Karl Kuchler
Keyword(s):  
Drug Resistance ◽  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Antifungal Drug ◽  
Antifungal Drug Resistance ◽  
Human Fungal Pathogen

Candida glabrata: Multidrug Resistance and Increased Virulence in a Major Opportunistic Fungal Pathogen

2012 ◽  
Vol 6 (3) ◽  
pp. 154-164 ◽  
Author(s):  
Michael A. Pfaller ◽  
Mariana Castanheira ◽  
Shawn R. Lockhart ◽  
Ronald N. Jones
Keyword(s):  
Multidrug Resistance ◽  
Fungal Pathogen ◽  
Candida Glabrata ◽  
Opportunistic Fungal Pathogen
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