scholarly journals Phenotypic and Molecular Characterization of Antimicrobial Resistance in Klebsiella spp. Isolates from Companion Animals in Japan: Clonal Dissemination of Multidrug-Resistant Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae

2016 ◽  
Vol 7 ◽  
Author(s):  
Kazuki Harada ◽  
Takae Shimizu ◽  
Yujiro Mukai ◽  
Ken Kuwajima ◽  
Tomomi Sato ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Klebsiella Pneumoniae ◽  
Molecular Characterization ◽  
Companion Animals ◽  
Multidrug Resistant ◽  
Extended Spectrum ◽  
Klebsiella Spp

scholarly journals Susceptibility ofKlebsiella pneumoniaeIsolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates

2011 ◽  
Vol 55 (8) ◽  
pp. 3917-3921 ◽  
Author(s):  
Stephen P. Hawser ◽  
Samuel K. Bouchillon ◽  
Christine Lascols ◽  
Meredith Hackel ◽  
Daryl J. Hoban ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Klebsiella Pneumoniae ◽  
Molecular Characterization ◽  
Clinical Isolates ◽  
Extended Spectrum ◽  
Clinical Breakpoints ◽  
Abdominal Infections

ABSTRACTA total of 2,841 clinical isolates ofKlebsiella pneumoniaefrom intra-abdominal infections worldwide were collected in the Study for Monitoring Antimicrobial Resistance Trends (SMART) during 2008 and 2009. Overall, 22.4% of isolates had extended-spectrum β-lactamases (ESBLs). The most active antibiotics among the 11 tested were imipenem, amikacin, and ertapenem, though even these, like all other comparators, were less consistently active against ESBL-positive isolates than against ESBL-negative isolates. Globally, 6.5% of isolates were ertapenem resistant based on the June 2010 clinical breakpoints published by the Clinical and Laboratory Standards Institute, with MICs of ≥1 μg/ml. Molecular characterization of 43 isolates with ertapenem MICs of ≥4 μg/ml showed that they variously produced CTX-M or SHV ESBLs combined with altered impermeability and/or had KPC (n= 28), OXA-48 (n= 3), or VIM (n= 1) carbapenemases. Further monitoring of ertapenem susceptibility and molecular characterization of ertapenem-resistant isolates are needed.

scholarly journals 1667. Change in characteristics of community-onset ciprofloxacin-resistant E. coli isolates causing community-acquired acute pyelonephritis in South Korea

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S820-S820
Author(s):  
Bongyoung Kim ◽  
Ki Tae Kwon ◽  
Seong-yeol Ryu ◽  
Seong-Heon Wie ◽  
Hyun-uk Jo ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
South Korea ◽  
Molecular Characterization ◽  
Acute Pyelonephritis ◽  
Multilocus Sequence Typing ◽  
Quinolone Resistance ◽  
E Coli ◽  
Extended Spectrum ◽  
Community Onset

Abstract Background The aim of this study was to examine the change in characteristics of community-onset ciprofloxacin-resistant (CIP-R) E. coli isolates causing community-acquired acute pyelonephritis (CA-APN) in South Korea between 2010-2011 and 2017-2018. Methods E. coli samples isolated from the blood or urine were collected from patients with CA-APN aged 19 years and more who were admitted to 8 Korean hospitals from September 2017 to August 2018, prospectively. One isolate was collected from each patient. Phylogenetic typing, multilocus sequence typing (MLST), and molecular characterization of β-lactamase resistance and plasmid-mediated quinolone resistance (PMQR) determinants were performed. The data were compared with those from the previous study with same design in 2010-2011. Results A total of 346 and 300 isolates were collected during 2017-2018 and 2010-2011, respectively. Among them, 76 (22.0%) and 77 (25.7%) were CIP-R isolates. Significantly higher antimicrobial resistance against ampicillin (75.7% vs. 100%, P < 0.001) and cefotaxime (23.9% vs. 77.9%, P < 0.001) were observed for isolates in 2017-2018 compared to those in 2010-2011. The proportion of phylogenic group B2 had increased significantly (44.7% vs. 79.2%, P < 0.001). As for MLST, the proportion of ST131 (27.6% vs. 66.2%, P < 0.001) had increased while that of ST393 (18.4% vs. 3.9%, P =0.004) had decreased significantly. Higher proportion of CIP-R E. coli isolates in 2017-2018 had extended-spectrum β-lactamase (ESBL)/plasmid-mediated AmpC β-lactamase (PABL) (23.7% vs. 79.2%, P < 0.001) and PMQR determinant (11.8% vs. 40.8%, P < 0.001) compared to those in 2010-2011. Phlogenetic tree Analyzed by SplitsTree Conclusion Among uropathogenic CIP-R E. coli isolates in South Korea, ST131 predominance had become more prominent and the proportion of containing ESBL/PABL and/or PMQR determinants had increased. Disclosures All Authors: No reported disclosures

scholarly journals Molecular characterization of clinical multidrug-resistant Klebsiella pneumoniae isolates

2014 ◽  
Vol 13 (1) ◽  
pp. 16 ◽  
Author(s):  
Xiaoli Cao ◽  
Xuejing Xu ◽  
Zhifeng Zhang ◽  
Han Shen ◽  
Junhao Chen ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Characterization ◽  
Multidrug Resistant

scholarly journals Phenotypic and molecular characterization of antimicrobial resistance in Enterobacter spp. isolates from companion animals in Japan

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174178 ◽  
Author(s):  
Kazuki Harada ◽  
Takae Shimizu ◽  
Yujiro Mukai ◽  
Ken Kuwajima ◽  
Tomomi Sato ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Molecular Characterization ◽  
Companion Animals

scholarly journals Molecular characterization of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp. isolates in Mongolia

2016 ◽  
Vol 49 (5) ◽  
pp. 692-700 ◽  
Author(s):  
Cheng-Yen Kao ◽  
Uuganbayar Udval ◽  
Yi-Ting Huang ◽  
Hsiu-Mei Wu ◽  
Ay-Huey Huang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Molecular Characterization ◽  
Extended Spectrum ◽  
Klebsiella Spp
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