scholarly journals Δ24-Sterol Methyltransferase Plays an Important Role in the Growth and Development of Sporothrix schenckii and Sporothrix brasiliensis

2016 ◽  
Vol 7 ◽  
Author(s):  
Luana P. Borba-Santos ◽  
Gonzalo Visbal ◽  
Thalita Gagini ◽  
Anderson M. Rodrigues ◽  
Zoilo P. de Camargo ◽  
...  
Keyword(s):  
Growth And Development ◽  
Sporothrix Schenckii ◽  
Sporothrix Brasiliensis ◽  
Sterol Methyltransferase

Synthesis and Antifungal Activity of Coumarins Derivatives Against Sporothrix spp.

2018 ◽  
Vol 18 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Luana da S.M. Forezi ◽  
Luana Pereira Borba-Santos ◽  
Mariana F.C. Cardoso ◽  
Vitor F. Ferreira ◽  
Sonia Rozental ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Sporothrix Schenckii ◽  
Public Health Problem ◽  
Domestic Animals ◽  
Coumarin Derivatives ◽  
Sporothrix Brasiliensis ◽  
Synthetic Routes ◽  
Effective Drugs

Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. The three-components synthetic routes used for the preparation of coumarin derivatives have proved to be quite efficient and compounds 16 and 17 have been prepared in good yields. The inhibitory activity of nineteen synthetic coumarins derivatives 16a-i and 17a-j were evaluated against Sporothrix spp. yeasts and the most potent compounds were 16b and 17i. However, according to concentrations able to inhibit (minimum inhibitory concentrations) and kill (minimum fungicidal concentrations) the cells, 17i was more effective than 16b against Sporothrix spp. Thus, 17i exhibited good antifungal activity against S. brasiliensis and S. schenckii, suggesting that it is an important scaffold for the development of novel antifungal agents.

scholarly journals Sporotrichosis in Mexico

2020 ◽  
Author(s):  
Conchita Toriello ◽  
Carolina Brunner-Mendoza ◽  
Estela Ruiz-Baca ◽  
Esperanza Duarte-Escalante ◽  
Amelia Pérez-Mejía ◽  
...  
Keyword(s):  
Systematic Review ◽  
Geographic Distribution ◽  
Sporothrix Schenckii ◽  
Public Information ◽  
Laboratory Diagnosis ◽  
Sensu Stricto ◽  
Sporothrix Brasiliensis ◽  
Source Of Infection ◽  
Common Clinical Presentation ◽  
Subcutaneous Mycoses

Abstract Sporotrichosis is an endemic mycosis caused by the species of the Sporothrix genus, and it is considered one of the most frequent subcutaneous mycoses in Mexico. This mycosis has become a relevant fungal infection in the last two decades. Today, much is known of its epidemiology and distribution, and its taxonomy has undergone revisions. New clinical species have been identified and classified through molecular tools, and they now include Sporothrix schenckii sensu stricto, Sporothrix brasiliensis, Sporothrix globosa, and Sporothrix luriei. In this article, we present a systematic review of sporotrichosis in Mexico that analyzes its epidemiology, geographic distribution, and diagnosis. The results show that the most common clinical presentation of sporotrichosis in Mexico is the lymphocutaneous form, with a higher incidence in the 0–15 age range, mainly in males, and for which trauma with plants is the most frequent source of infection. In Mexico, the laboratory diagnosis of sporotrichosis is mainly carried out using conventional methods, but in recent years, several researchers have used molecular methods to identify the Sporothrix species. The treatment of choice depends mainly on the clinical form of the disease, the host’s immunological status, and the species of Sporothrix involved. Despite the significance of this mycosis in Mexico, public information about sporotrichosis is scarce, and it is not considered reportable according to Mexico’s epidemiological national system, the “Sistema Nacional de Vigilancia Epidemiológica.” Due to the lack of data in Mexico regarding the epidemiology of this disease, we present a systematic review of sporotrichosis in Mexico, between 1914 and 2019, that analyzes its epidemiology, geographic distribution, and diagnosis.

scholarly journals Comparison of Cell Wall Polysaccharide Composition and Structure Between Strains of Sporothrix schenckii and Sporothrix brasiliensis

2021 ◽  
Vol 12 ◽  
Author(s):  
Héctor L. Villalobos-Duno ◽  
Laura A. Barreto ◽  
Álvaro Alvarez-Aular ◽  
Héctor M. Mora-Montes ◽  
Nancy E. Lozoya-Pérez ◽  
...  
Keyword(s):  
Cell Wall ◽  
Sporothrix Schenckii ◽  
Cell Wall Composition ◽  
Cell Wall Polysaccharide ◽  
Sporothrix Brasiliensis ◽  
Composition And Structure ◽  
Causative Agents ◽  
Polysaccharide Composition ◽  
Pathogenic Process

Sporothrix schenckii, Sporothrix brasiliensis, and Sporothrix globosa are the main causative agents of sporotrichosis, a human subcutaneous mycosis. Differences in virulence patterns are associated with each species but remain largely uncharacterized. The S. schenckii and S. brasiliensis cell wall composition and virulence are influenced by the culturing media, with little or no influence on S. globosa. By keeping constant the culturing media, we compared the cell wall composition of three S. schenckii and two S. brasiliensis strains, previously described as presenting different virulence levels on a murine model of infection. The cell wall composition of the five Sporothrix spp. strains correlated with the biochemical composition of the cell wall previously reported for the species. However, the rhamnose-to-β-glucan ratio exhibits differences among strains, with an increase in cell wall rhamnose-to-β-glucan ratio as their virulence increased. This relationship can be expressed mathematically, which could be an important tool for the determination of virulence in Sporothrix spp. Also, structural differences in rhamnomannan were found, with longer side chains present in strains with lower virulence reported for both species here studied, adding insight to the importance of this polysaccharide in the pathogenic process of these fungi.

scholarly journals Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and Sporothrix spp.

2020 ◽  
Vol 64 (5) ◽  
Author(s):  
Jose Aleixo de Azevedo-França ◽  
Renato Granado ◽  
Sara Teixeira de Macedo Silva ◽  
Gabrielle dos Santos-Silva ◽  
Sandra Scapin ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Sporothrix Schenckii ◽  
Parasitic Diseases ◽  
Protozoan Parasites ◽  
Content Type ◽  
Sporothrix Brasiliensis ◽  
Low Concentrations ◽  
Elemental Analyses ◽  
Zinc Salts ◽  
Medical Importance

ABSTRACT The new complexes Zn(ITZ)2Cl2 (1) and Zn(ITZ)2(OH)2 (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spectrometry, 1H and 13C{1H} nuclear magnetic resonance, and UV-vis and infrared spectroscopies. The antiparasitic and antifungal activity of Zn-ITZ complexes was evaluated against three protozoans of medical importance, namely, Leishmania amazonensis, Trypanosoma cruzi, and Toxoplasma gondii, and two fungi, namely, Sporothrix brasiliensis and Sporothrix schenckii. The Zn-ITZ complexes exhibited a broad spectrum of action, with antiparasitic and antifungal activity in low concentrations. The strategy of combining zinc with ITZ was efficient to enhance ITZ activity since Zn-ITZ-complexes were more active than the azole alone. This study opens perspectives for future applications of these Zn-ITZ complexes in the treatment of parasitic diseases and sporotrichosis.

Interaction with Pantoea agglomerans Modulates Growth and Melanization of Sporothrix brasiliensis and Sporothrix schenckii

2019 ◽  
Vol 184 (3) ◽  
pp. 367-381 ◽  
Author(s):  
Rodrigo Almeida-Paes ◽  
Fábio Brito-Santos ◽  
Manoel Marques Evangelista Oliveira ◽  
Alexandre Melo Bailão ◽  
Clayton Luiz Borges ◽  
...  
Keyword(s):  
Sporothrix Schenckii ◽  
Pantoea Agglomerans ◽  
Sporothrix Brasiliensis

The interaction between Sporothrix schenckii sensu stricto and Sporothrix brasiliensis with Acanthamoeba castellanii

Mycoses ◽  
2019 ◽  
Vol 63 (3) ◽  
pp. 302-307 ◽  
Author(s):  
Priscila Lemos Tavares ◽  
Amanda Carvalho Ribeiro ◽  
Francisco Kercher Berte ◽  
Alessandra Helena Silva Hellwig ◽  
Danielle Machado Pagani ◽  
...  
Keyword(s):  
Sporothrix Schenckii ◽  
Acanthamoeba Castellanii ◽  
Sensu Stricto ◽  
Sporothrix Brasiliensis

Sporothrix brasiliensis on cats with skin ulcers in Southern Brazil

2020 ◽  
Author(s):  
Andréia Spanamberg ◽  
Ricardo Araujo ◽  
Ana Paulo Ravazzolo ◽  
David Driemeier ◽  
Rosane Maria Sordi Driemeier ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Genetic Variants ◽  
Molecular Level ◽  
Sporothrix Schenckii ◽  
Southern Brazil ◽  
Porto Alegre ◽  
Dimorphic Fungi ◽  
Sporothrix Brasiliensis ◽  
Fungal Isolates ◽  
Skin Ulcers

Abstract Sporotrichosis is a disease caused by thermally dimorphic fungi belonging to the Sporothrix schenckii complex. We report the occurrence of multiple cases of sporotrichosis in cats in Porto Alegre (RS), Brazil, from 2015 to 2019. A set of 21 fungal isolates were collected and the partial sequence of calmodulin (CAL) gene compared. All isolates were identified at phenotypic and molecular level as S. brasiliensis. Phylogenetic analysis showed the isolates clustered in two distinct groups, suggesting the presence of multiple genetic variants of S. brasiliensis in the region.

Sign in / Sign up

Export Citation Format

Share Document