The interaction between Sporothrix schenckii sensu stricto and Sporothrix brasiliensis with Acanthamoeba castellanii

Mycoses ◽  
2019 ◽  
Vol 63 (3) ◽  
pp. 302-307 ◽  
Author(s):  
Priscila Lemos Tavares ◽  
Amanda Carvalho Ribeiro ◽  
Francisco Kercher Berte ◽  
Alessandra Helena Silva Hellwig ◽  
Danielle Machado Pagani ◽  
...  
Keyword(s):  
Sporothrix Schenckii ◽  
Acanthamoeba Castellanii ◽  
Sensu Stricto ◽  
Sporothrix Brasiliensis

scholarly journals Sporotrichosis in Mexico

2020 ◽  
Author(s):  
Conchita Toriello ◽  
Carolina Brunner-Mendoza ◽  
Estela Ruiz-Baca ◽  
Esperanza Duarte-Escalante ◽  
Amelia Pérez-Mejía ◽  
...  
Keyword(s):  
Systematic Review ◽  
Geographic Distribution ◽  
Sporothrix Schenckii ◽  
Public Information ◽  
Laboratory Diagnosis ◽  
Sensu Stricto ◽  
Sporothrix Brasiliensis ◽  
Source Of Infection ◽  
Common Clinical Presentation ◽  
Subcutaneous Mycoses

Abstract Sporotrichosis is an endemic mycosis caused by the species of the Sporothrix genus, and it is considered one of the most frequent subcutaneous mycoses in Mexico. This mycosis has become a relevant fungal infection in the last two decades. Today, much is known of its epidemiology and distribution, and its taxonomy has undergone revisions. New clinical species have been identified and classified through molecular tools, and they now include Sporothrix schenckii sensu stricto, Sporothrix brasiliensis, Sporothrix globosa, and Sporothrix luriei. In this article, we present a systematic review of sporotrichosis in Mexico that analyzes its epidemiology, geographic distribution, and diagnosis. The results show that the most common clinical presentation of sporotrichosis in Mexico is the lymphocutaneous form, with a higher incidence in the 0–15 age range, mainly in males, and for which trauma with plants is the most frequent source of infection. In Mexico, the laboratory diagnosis of sporotrichosis is mainly carried out using conventional methods, but in recent years, several researchers have used molecular methods to identify the Sporothrix species. The treatment of choice depends mainly on the clinical form of the disease, the host’s immunological status, and the species of Sporothrix involved. Despite the significance of this mycosis in Mexico, public information about sporotrichosis is scarce, and it is not considered reportable according to Mexico’s epidemiological national system, the “Sistema Nacional de Vigilancia Epidemiológica.” Due to the lack of data in Mexico regarding the epidemiology of this disease, we present a systematic review of sporotrichosis in Mexico, between 1914 and 2019, that analyzes its epidemiology, geographic distribution, and diagnosis.

Analysis of Sporothrix schenckii sensu stricto and Sporothrix brasiliensis virulence in Galleria mellonella

2016 ◽  
Vol 122 ◽  
pp. 73-77 ◽  
Author(s):  
Diana M. Clavijo-Giraldo ◽  
José A. Matínez-Alvarez ◽  
Leila M. Lopes-Bezerra ◽  
Patricia Ponce-Noyola ◽  
Bernardo Franco ◽  
...  
Keyword(s):  
Galleria Mellonella ◽  
Sporothrix Schenckii ◽  
Sensu Stricto ◽  
Sporothrix Brasiliensis

scholarly journals Sporothrix brasiliensis induces a more severe disease associated with sustained Th17 and regulatory T cells responses than Sporothrix schenckii sensu stricto in mice

2018 ◽  
Vol 122 (12) ◽  
pp. 1163-1170 ◽  
Author(s):  
Alexander Batista-Duharte ◽  
Damiana Téllez-Martínez ◽  
Cleverton Roberto de Andrade ◽  
Deivys Leandro Portuondo ◽  
Juliana Aparecida Jellmayer ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Severe Disease ◽  
Sporothrix Schenckii ◽  
Sensu Stricto ◽  
Sporothrix Brasiliensis

scholarly journals In VitroandIn VivoEfficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis

2015 ◽  
Vol 59 (8) ◽  
pp. 5018-5021 ◽  
Author(s):  
Débora Nunes Mario ◽  
Josep Guarro ◽  
Janio Morais Santurio ◽  
Sydney Hartz Alves ◽  
Javier Capilla
Keyword(s):  
Synergistic Effect ◽  
Amphotericin B ◽  
Murine Model ◽  
Sporothrix Schenckii ◽  
Sensu Stricto ◽  
Content Type ◽  
Sporothrix Brasiliensis ◽  
Systemic Infections

ABSTRACTWe evaluated the combination of posaconazole with amphotericin Bin vitroand in a murine model of systemic infections caused bySporothrix brasiliensisandSporothrix schenckiisensu stricto.In vitrodata demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.

scholarly journals Efficacy of Posaconazole in Murine Experimental Sporotrichosis

2012 ◽  
Vol 56 (5) ◽  
pp. 2273-2277 ◽  
Author(s):  
Fabiola Fernández-Silva ◽  
Javier Capilla ◽  
Emilio Mayayo ◽  
Josep Guarro
Keyword(s):  
Body Weight ◽  
Amphotericin B ◽  
Murine Model ◽  
Sporothrix Schenckii ◽  
Sensu Stricto ◽  
Control Treatment ◽  
Content Type ◽  
Good Efficacy ◽  
Sporothrix Brasiliensis ◽  
Tissue Burden

ABSTRACTWe developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e.,Sporothrix schenckiisensu stricto andSporothrix brasiliensis, in order to evaluate the efficacy of posaconazole (PSC). The drug was administered at a dose of 2.5 or 5 mg/kg of body weight twice a day by gavage, and one group was treated with amphotericin B (AMB) as a control treatment. Posaconazole, especially at 5 mg/kg, showed good efficacy against all the strains tested, regardless of their MICs, as measured by prolonged survival, tissue burden reduction, and histopathology.

Synthesis and Antifungal Activity of Coumarins Derivatives Against Sporothrix spp.

2018 ◽  
Vol 18 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Luana da S.M. Forezi ◽  
Luana Pereira Borba-Santos ◽  
Mariana F.C. Cardoso ◽  
Vitor F. Ferreira ◽  
Sonia Rozental ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agents ◽  
Sporothrix Schenckii ◽  
Public Health Problem ◽  
Domestic Animals ◽  
Coumarin Derivatives ◽  
Sporothrix Brasiliensis ◽  
Synthetic Routes ◽  
Effective Drugs

Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. The three-components synthetic routes used for the preparation of coumarin derivatives have proved to be quite efficient and compounds 16 and 17 have been prepared in good yields. The inhibitory activity of nineteen synthetic coumarins derivatives 16a-i and 17a-j were evaluated against Sporothrix spp. yeasts and the most potent compounds were 16b and 17i. However, according to concentrations able to inhibit (minimum inhibitory concentrations) and kill (minimum fungicidal concentrations) the cells, 17i was more effective than 16b against Sporothrix spp. Thus, 17i exhibited good antifungal activity against S. brasiliensis and S. schenckii, suggesting that it is an important scaffold for the development of novel antifungal agents.

Identification of multiple species and subpopulations among Australian clinical Sporothrix isolates using whole genome sequencing

2018 ◽  
Vol 57 (7) ◽  
pp. 905-908 ◽  
Author(s):  
David New ◽  
Alicia G Beukers ◽  
Sarah E Kidd ◽  
Adam J Merritt ◽  
Kerry Weeks ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Sporothrix Schenckii ◽  
Sensu Stricto ◽  
Northern Territory ◽  
Whole Genome ◽  
Phylogenetic Resolution ◽  
Genetic Clustering ◽  
Multiple Species

AbstractWhole genome sequencing (WGS) was used to demonstrate the wide genetic variability within Sporothrix schenckii sensu lato and establish that there are two main species of Sporothrix within Australian clinical isolates—S. schenckii sensu stricto and Sporothrix globosa. We also demonstrated southwest Western Australia contained genetically similar S. schenckii ss strains that are distinct from strains isolated in the eastern and northern states of Australia. Some genetic clustering by region was also noted for northern NSW, Queensland, and Northern Territory. Phylogenetic analysis of WGS data provided greater phylogenetic resolution compared to analysis of the calmodulin gene alone.

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