scholarly journals Fluoroquinolone Resistance Mechanisms and population structure of Enterobacter cloacae non-susceptible to Ertapenem in North-Eastern France

2015 ◽  
Vol 6 ◽  
Author(s):  
Thomas Guillard ◽  
Pascal Cholley ◽  
Anne Limelette ◽  
Didier Hocquet ◽  
Lucie Matton ◽  
...  
Keyword(s):  
Population Structure ◽  
Enterobacter Cloacae ◽  
Resistance Mechanisms ◽  
Fluoroquinolone Resistance ◽  
North Eastern

scholarly journals Characterization of resistance mechanisms of Enterobacter cloacae Complex co-resistant to carbapenem and colistin

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shixing Liu ◽  
Renchi Fang ◽  
Ying Zhang ◽  
Lijiang Chen ◽  
Na Huang ◽  
...  
Keyword(s):  
Lipid A ◽  
Efflux Pump ◽  
Resistance Mechanism ◽  
Carbapenem Resistance ◽  
Enterobacter Cloacae ◽  
Resistance Mechanisms ◽  
Colistin Resistance ◽  
Carbapenem Resistant ◽  
Horizontal Spread

Abstract Background The emergence of carbapenem-resistant and colistin-resistant ECC pose a huge challenge to infection control. The purpose of this study was to clarify the mechanism of the carbapenems and colistin co-resistance in Enterobacter cloacae Complex (ECC) strains. Results This study showed that the mechanisms of carbapenem resistance in this study are: 1. Generating carbapenemase (7 of 19); 2. The production of AmpC or ESBLs combined with decreased expression of out membrane protein (12 of 19). hsp60 sequence analysis suggested 10 of 19 the strains belong to colistin hetero-resistant clusters and the mechanism of colistin resistance is increasing expression of acrA in the efflux pump AcrAB-TolC alone (18 of 19) or accompanied by a decrease of affinity between colistin and outer membrane caused by the modification of lipid A (14 of 19). Moreover, an ECC strain co-harboring plasmid-mediated mcr-4.3 and blaNDM-1 has been found. Conclusions This study suggested that there is no overlap between the resistance mechanism of co-resistant ECC strains to carbapenem and colistin. However, the emergence of strain co-harboring plasmid-mediated resistance genes indicated that ECC is a potential carrier for the horizontal spread of carbapenems and colistin resistance.

scholarly journals Cefazolin and Imipenem Enhance AmpC Expression and Resistance in NagZ-Dependent Manner in Enterobacter Cloacae

2021 ◽  
Author(s):  
Xianggui Yang ◽  
Zhenguo Wang ◽  
Xuejing Yu ◽  
Yuanxiu Zhong ◽  
Fuying Wang ◽  
...  
Keyword(s):  
Clinical Isolate ◽  
Target Genes ◽  
Ectopic Expression ◽  
Enterobacter Cloacae ◽  
Opportunistic Pathogen ◽  
Resistance Mechanisms ◽  
Induction Effect ◽  
Dependent Manner ◽  
Critical Determinant ◽  
2Nd Generation

Abstract Background: Enterobacter cloacae (EC) is a commonly occurring opportunistic pathogen and is responsible for causing various infections in humans. Owing to its inducible chromosomal AmpC β-lactamase (AmpC), EC is inherently resistant to the 1st- and 2nd- generation cephalosporins. However, whether β-lactams antibiotics enhance EC resistance remains unclear.Results: In this study, we found that subinhibitory concentrations (SICs) of cefazolin (CFZ) and imipenem (IMP) are able to advance the expression of AmpC and improve its resistance towards β - lactams through NagZ in EC clinical isolate. Our work indicate that AmpC manifested a substantial upregulation in EC in response to SICs of CFZ and IMP. In nagZ knockout EC (ΔnagZ), we found that the resistance to β - lactam antibiotics was rather weakened and the effect of CFZ and IMP on induction of AmpC was completely abrogated. Ectopic expression of NagZ can rescue the induction effect of CFZ and IMP on AmpC and enhance resistance in ΔnagZ. More importantly, CFZ and IMP have the potential to bring about the target genes expressions of AmpR in a NagZ-dependent manner.Conclusions: Our findings show that NagZ is a critical determinant for CFZ and IMP to promote AmpC expression and improve resistance and that CFZ and IMP should be used with caution since they may aggravate EC resistance. At the same time, this study further improves our understanding of resistance mechanisms in EC.

scholarly journals Analysis of Genetic Diversity and Population Structure of Rice Germplasm from North-Eastern Region of India and Development of a Core Germplasm Set

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e113094 ◽  
Author(s):  
Debjani Roy Choudhury ◽  
Nivedita Singh ◽  
Amit Kumar Singh ◽  
Sundeep Kumar ◽  
Kalyani Srinivasan ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Population Structure ◽  
Eastern Region ◽  
Rice Germplasm ◽  
North Eastern ◽  
Core Germplasm

First characterization of fluoroquinolone resistance mechanisms in CTX-M-producing Escherichia coli from Mongolia

2016 ◽  
Vol 38 ◽  
pp. 79-81 ◽  
Author(s):  
Cheng-Yen Kao ◽  
Uuganbayar Udval ◽  
Hsiu-Mei Wu ◽  
Enkhbaatar Bolormaa ◽  
Jing-Jou Yan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Resistance Mechanisms ◽  
Fluoroquinolone Resistance

scholarly journals Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Eva Heinz ◽  
Hasan Ejaz ◽  
Josefin Bartholdson Scott ◽  
Nancy Wang ◽  
Shruti Gujaran ◽  
...  
Keyword(s):  
Population Structure ◽  
Resistance Mechanisms ◽  
Drug Resistant

scholarly journals Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem.

1991 ◽  
Vol 35 (6) ◽  
pp. 1093-1098 ◽  
Author(s):  
E H Lee ◽  
M H Nicolas ◽  
M D Kitzis ◽  
G Pialoux ◽  
E Collatz ◽  
...  
Keyword(s):  
Clinical Isolate ◽  
Enterobacter Cloacae ◽  
Resistance Mechanisms ◽  
High Level ◽  
Level Resistance
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