scholarly journals Targeting the Oxidative Stress Response System of Fungi with Redox-Potent Chemosensitizing Agents

2012 ◽  
Vol 3 ◽  
Author(s):  
Jong H. Kim ◽  
Kathleen L. Chan ◽  
Natália C. G. Faria ◽  
M. de L. Martins ◽  
Bruce C. Campbell
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Response System ◽  
Stress Response System

The oxidative stress response system

2004 ◽  
pp. 59-76 ◽  
Author(s):  
André Korsloot ◽  
Cornelis A.M. van Gestel ◽  
Nico M. van Straalen
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Response System ◽  
Stress Response System

scholarly journals Increased Oxidative Stress Response in Granulocytes from Older Patients with a Hip Fracture May Account for Slow Regeneration

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Zhiyong Wang ◽  
Sabrina Ehnert ◽  
Christoph Ihle ◽  
Lilianna Schyschka ◽  
Stefan Pscherer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Age Groups ◽  
Young Patients ◽  
The Elderly ◽  
Oxidative Stress Response ◽  
Proximal Femur Fracture ◽  
Mapk Activation ◽  
Stress Markers ◽  
Stress Response System

Proximal femur fracture, a typical fracture of the elderly, is often associated with morbidity, reduced quality of life, impaired physical function and increased mortality. There exists evidence that responses of the hematopoietic microenvironment to fractures change with age. Therefore, we investigated oxidative stress markers and oxidative stress-related MAPK activation in granulocytes from the young and the elderly with and without fractured long bones. Lipid peroxidation levels were increased in the elderly controls and patients. Aged granulocytes were more sensitive towards oxidative stress induced damage than young granulocytes. This might be due to the basally increased expression of SOD-1 in the elderly, which was not further induced by fractures, as observed in young patients. This might be caused by an altered MAPK activation. In aged granulocytes basal p38 and JNK activities were increased and basal ERK1/2 activity was decreased. Following fracture, JNK activity decreased, while ERK1/2 and p38 activities increased in both age groups. Control experiments with HL60 cells revealed that the observed p38 activation depends strongly on age. Summarizing, we observed age-dependent changes in the oxidative stress response system of granulocytes after fractures, for example, altered MAPK activation and SOD-1 expression. This makes aged granulocytes vulnerable to the stress stimuli of the fracture and following surgery.

From germ cells to neonates: the beginning of life and the KEAP1–NRF2 system

2019 ◽  
Author(s):  
Daisuke Matsumaru ◽  
Hozumi Motohashi
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Embryonic Development ◽  
Germ Cells ◽  
Target Genes ◽  
Related Factor ◽  
Environmental Stress Response ◽  
Response System ◽  
Response Systems ◽  
Stress Response System

Abstract The Kelch-like ECH-associated protein 1(KEAP1)–NF-E2-related factor 2 (NRF2) system is one of the most studied environmental stress response systems. In the presence of oxidative and electrophilic insults, the thiols of cysteine residues in KEAP1 are modified, and subsequently stabilized NRF2 activates its target genes that are involved in detoxification and cytoprotection. A myriad of recent studies has revealed the broad range of contributions of the KEAP1–NRF2 system to physiological and pathological processes. However, its functions during gametic and embryonic development are still open for investigation. Although oxidative stress is harmful for embryos, Nrf2−/− mice do not show any apparent morphological abnormalities during development, probably because of the compensatory antioxidant functions of NF-E2-related factor 1 (NRF1). It can also be considered that the antioxidant system is essential for protecting germ cells during reproduction. The maturation processes of germ cells in both sexes are affected by Nrf2 mutation. Hence, in this review, we focus on the stress response system related to reproduction and embryonic development through the functions of the KEAP1–NRF2 system.

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