scholarly journals The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis

2018 ◽  
Vol 5 ◽  
Author(s):  
Robert J. Ju ◽  
Samantha J. Stehbens ◽  
Nikolas K. Haass
Keyword(s):  
Cell Motility ◽  
Melanoma Cell ◽  
Invasion And Metastasis

scholarly journals The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors

2006 ◽  
Vol 173 (3) ◽  
pp. 395-404 ◽  
Author(s):  
Weigang Wang ◽  
Ghassan Mouneimne ◽  
Mazen Sidani ◽  
Jeffrey Wyckoff ◽  
Xiaoming Chen ◽  
...  
Keyword(s):  
Cell Motility ◽  
Cell Invasion ◽  
Actin Polymerization ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Over Expression ◽  
Cell Biol ◽  
Tumor Cell Motility ◽  
New Strategies

Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis, and therapy of metastatic cancers. LIM kinase1 (LIMK1) is a member of a novel class of serine–threonine protein kinases. Cofilin, a LIMK1 substrate, is essential for the regulation of actin polymerization and depolymerization during cell migration. Previous studies have made opposite conclusions as to the role of LIMK1 in tumor cell motility and metastasis, claiming either an increase or decrease in cell motility and metastasis as a result of LIMK1 over expression (Zebda, N., O. Bernard, M. Bailly, S. Welti, D.S. Lawrence, and J.S. Condeelis. 2000. J. Cell Biol. 151:1119–1128; Davila, M., A.R. Frost, W.E. Grizzle, and R. Chakrabarti. 2003. J. Biol. Chem. 278:36868–36875; Yoshioka, K., V. Foletta, O. Bernard, and K. Itoh. 2003. Proc. Natl. Acad. Sci. USA. 100:7247–7252; Nishita, M., C. Tomizawa, M. Yamamoto, Y. Horita, K. Ohashi, and K. Mizuno. 2005. J. Cell Biol. 171:349–359). We resolve this paradox by showing that the effects of LIMK1 expression on migration, intravasation, and metastasis of cancer cells can be most simply explained by its regulation of the output of the cofilin pathway. LIMK1-mediated decreases or increases in the activity of the cofilin pathway are shown to cause proportional decreases or increases in motility, intravasation, and metastasis of tumor cells.

Role of α6β4 Integrin in Cell Motility, Invasion and Metastasis of Mammary Tumors

2011 ◽  
Vol 12 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Jun Chung ◽  
John L. Clifford ◽  
Young Hwa Soung ◽  
Hyea Jin Gil
Keyword(s):  
Cell Motility ◽  
Mammary Tumors ◽  
Invasion And Metastasis

scholarly journals Long Noncoding RNA HOTAIR Is Associated with Motility, Invasion, and Metastatic Potential of Metastatic Melanoma

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Lihua Tang ◽  
Wei Zhang ◽  
Bing Su ◽  
Bo Yu
Keyword(s):  
Lymph Node ◽  
Cell Motility ◽  
Metastatic Melanoma ◽  
Melanoma Cell ◽  
Noncoding Rna ◽  
Primary Melanoma ◽  
Melanoma Metastasis ◽  
Gelatin Matrix ◽  
Gelatinase Activity

Metastatic melanoma, the primary cause of skin cancer-related death, warrants new therapeutic approaches that target the regulatory machinery at molecular level. While long noncoding RNAs (lncRNAs) are dysregulated in a number of cancer types, limited data are available on the expression and function of lncRNAs in melanoma metastasis. The primary objective of this study was to investigate the role of 6 metastasis-related lncRNAs in pairs of primary melanoma and matched lymph node metastatic tissues. Among the tested lncRNAs, HOTAIR was the most highly expressed in lymph node metastasis. The role of HOTAIR in melanoma cell motility and invasion was further evaluated by knocking down HOTAIR with siRNAs. Knockdown of HOTAIR resulted in the reduction of motility and invasion of human melanoma cell line A375, as assessed by wound healing assay and Matrigel-based invasion assay. siHOTAIR also suppressed the degradation of gelatin matrix, suggesting that HOTAIR promotes gelatinase activity. Together, our study shows that HOTAIR is overexpressed in metastatic tissue, which is associated with the ability of HOTAIR to promote melanoma cell motility and invasion. These data indicate that lncRNAs may be involved in the metastasis of melanoma and provide support for further evaluation of lncRNAs in melanoma.

Role of NCAM in cell motility, invasion and metastasis

1992 ◽  
Vol 21 ◽  
pp. S15
Author(s):  
E. Bock ◽  
C.H. Barton ◽  
F. Walsh ◽  
K. Edvardsen
Keyword(s):  
Cell Motility ◽  
Invasion And Metastasis

Contextual role of E2F1 in suppression of melanoma cell motility and invasiveness

2019 ◽  
Vol 58 (9) ◽  
pp. 1701-1710
Author(s):  
Peng Meng ◽  
Roble G. Bedolla ◽  
Huiyoung Yun ◽  
James E. Fitzpatrick ◽  
Addanki P. Kumar ◽  
...  
Keyword(s):  
Cell Motility ◽  
Melanoma Cell
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