scholarly journals Role of microRNA-21 in uveal melanoma cell invasion and metastasis by regulating p53 and its downstream protein

2018 ◽  
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Cell Invasion ◽  
Invasion And Metastasis ◽  
Uveal Melanoma Cell

scholarly journals A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of α1β1, α4β1 and α6β1 integrins

2001 ◽  
Vol 85 (6) ◽  
pp. 732-738 ◽  
Author(s):  
Shona R Elshaw ◽  
Karen Sisley ◽  
Neil Cross ◽  
Anna K Murray ◽  
Shiela M MacNeil ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Cell Invasion ◽  
Uveal Melanoma Cell

scholarly journals The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors

2006 ◽  
Vol 173 (3) ◽  
pp. 395-404 ◽  
Author(s):  
Weigang Wang ◽  
Ghassan Mouneimne ◽  
Mazen Sidani ◽  
Jeffrey Wyckoff ◽  
Xiaoming Chen ◽  
...  
Keyword(s):  
Cell Motility ◽  
Cell Invasion ◽  
Actin Polymerization ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Over Expression ◽  
Cell Biol ◽  
Tumor Cell Motility ◽  
New Strategies

Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis, and therapy of metastatic cancers. LIM kinase1 (LIMK1) is a member of a novel class of serine–threonine protein kinases. Cofilin, a LIMK1 substrate, is essential for the regulation of actin polymerization and depolymerization during cell migration. Previous studies have made opposite conclusions as to the role of LIMK1 in tumor cell motility and metastasis, claiming either an increase or decrease in cell motility and metastasis as a result of LIMK1 over expression (Zebda, N., O. Bernard, M. Bailly, S. Welti, D.S. Lawrence, and J.S. Condeelis. 2000. J. Cell Biol. 151:1119–1128; Davila, M., A.R. Frost, W.E. Grizzle, and R. Chakrabarti. 2003. J. Biol. Chem. 278:36868–36875; Yoshioka, K., V. Foletta, O. Bernard, and K. Itoh. 2003. Proc. Natl. Acad. Sci. USA. 100:7247–7252; Nishita, M., C. Tomizawa, M. Yamamoto, Y. Horita, K. Ohashi, and K. Mizuno. 2005. J. Cell Biol. 171:349–359). We resolve this paradox by showing that the effects of LIMK1 expression on migration, intravasation, and metastasis of cancer cells can be most simply explained by its regulation of the output of the cofilin pathway. LIMK1-mediated decreases or increases in the activity of the cofilin pathway are shown to cause proportional decreases or increases in motility, intravasation, and metastasis of tumor cells.

The prognostic value of uveal melanoma cell type

2021 ◽  
Vol 83 (4) ◽  
pp. 14
Author(s):  
V.A. Yarovaya ◽  
A.V. Shatskikh ◽  
A.R. Zaretsky ◽  
I.A. Levashov ◽  
D.P. Volodin ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Prognostic Value ◽  
Cell Type ◽  
Uveal Melanoma Cell

Depsipeptide (FR901228) Inhibits Proliferation and Induces Apoptosis in Primary and Metastatic Human Uveal Melanoma Cell Lines

2003 ◽  
Vol 44 (6) ◽  
pp. 2390 ◽  
Author(s):  
Dino D. Klisovic ◽  
Steven E. Katz ◽  
David Effron ◽  
Marko I. Klisovic ◽  
Joseph Wickham ◽  
...  
Keyword(s):  
Cell Lines ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Lines

scholarly journals The Role of WAVE2 Signaling in Cancer

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1217
Author(s):  
Priyanka Shailendra Rana ◽  
Akram Alkrekshi ◽  
Wei Wang ◽  
Vesna Markovic ◽  
Khalid Sossey-Alaoui
Keyword(s):  
Actin Cytoskeleton ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Critical Role ◽  
Therapeutic Strategies ◽  
Small Gtpases ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Regulatory Complex

The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE)—WAVE1, WAVE2 and WAVE3 regulate rapid reorganization of cortical actin filaments and have been shown to form a key link between small GTPases and the actin cytoskeleton. Upon receiving upstream signals from Rho-family GTPases, the WASP and WAVE family proteins play a significant role in polymerization of actin cytoskeleton through activation of actin-related protein 2/3 complex (Arp2/3). The Arp2/3 complex, once activated, forms actin-based membrane protrusions essential for cell migration and cancer cell invasion. Thus, by activation of Arp2/3 complex, the WAVE and WASP family proteins, as part of the WAVE regulatory complex (WRC), have been shown to play a critical role in cancer cell invasion and metastasis, drawing significant research interest over recent years. Several studies have highlighted the potential for targeting the genes encoding either part of or a complete protein from the WASP/WAVE family as therapeutic strategies for preventing the invasion and metastasis of cancer cells. WAVE2 is well documented to be associated with the pathogenesis of several human cancers, including lung, liver, pancreatic, prostate, colorectal and breast cancer, as well as other hematologic malignancies. This review focuses mainly on the role of WAVE2 in the development, invasion and metastasis of different types of cancer. This review also summarizes the molecular mechanisms that regulate the activity of WAVE2, as well as those oncogenic pathways that are regulated by WAVE2 to promote the cancer phenotype. Finally, we discuss potential therapeutic strategies that target WAVE2 or the WAVE regulatory complex, aimed at preventing or inhibiting cancer invasion and metastasis.

scholarly journals Genotype-Dependent Sensitivity of Uveal Melanoma Cell Lines to Inhibition of B-Raf, MEK, and Akt Kinases: Rationale for Personalized Therapy

2011 ◽  
Vol 52 (10) ◽  
pp. 7248 ◽  
Author(s):  
Nicholas Mitsiades ◽  
Sue Anne Chew ◽  
Bin He ◽  
Aline I. Riechardt ◽  
Theano Karadedou ◽  
...  
Keyword(s):  
Cell Lines ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Personalized Therapy ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Lines

Role of phospholipase C in cell invasion and metastasis

2013 ◽  
Vol 53 (3) ◽  
pp. 309-318 ◽  
Author(s):  
Rossano Lattanzio ◽  
Mauro Piantelli ◽  
Marco Falasca
Keyword(s):  
Phospholipase C ◽  
Cell Invasion ◽  
Invasion And Metastasis

Molecular cytogenetic evaluation of 10 uveal melanoma cell lines

2006 ◽  
Vol 168 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Jason S. White ◽  
Robert L. Becker ◽  
Ian W. McLean ◽  
Alison E. Director-Myska ◽  
Joginder Nath
Keyword(s):  
Cell Lines ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Molecular Cytogenetic ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Lines

Abstract 3584: Effects of the investigational selective MEK inhibitor TAK-733 against cutaneous and uveal melanoma cell lines

2011 ◽  
Author(s):  
Erika von Euw ◽  
Mohammad Atefi ◽  
Narsis Attar ◽  
Sybil Zachariah ◽  
Barry L. Burgess ◽  
...  
Keyword(s):  
Cell Lines ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Mek Inhibitor ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Lines
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