scholarly journals Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus

2017 ◽  
Vol 7 ◽  
Author(s):  
Chengmin Wang ◽  
Pengpeng Liu ◽  
Jing Luo ◽  
Hua Ding ◽  
Yan Gao ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
H5n1 Influenza Virus ◽  
H5n1 Influenza ◽  
Highly Virulent

scholarly journals The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome

2016 ◽  
Vol 60 (4) ◽  
pp. 2118-2131 ◽  
Author(s):  
Tatiana Baranovich ◽  
Jeremy C. Jones ◽  
Marion Russier ◽  
Peter Vogel ◽  
Kristy J. Szretter ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Influenza Virus ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Pulmonary Complications ◽  
Lung Injury Score ◽  
Dependent Manner ◽  
Dose Dependent

ABSTRACTMost cases of severe influenza are associated with pulmonary complications, such as acute respiratory distress syndrome (ARDS), and no antiviral drugs of proven value for treating such complications are currently available. The use of monoclonal antibodies targeting the stem of the influenza virus surface hemagglutinin (HA) is a rapidly developing strategy for the control of viruses of multiple HA subtypes. However, the mechanisms of action of these antibodies are not fully understood, and their ability to mitigate severe complications of influenza has been poorly studied. We evaluated the effect of treatment with VIS410, a human monoclonal antibody targeting the HA stem region, on the development of ARDS in BALB/c mice after infection with influenza A(H7N9) viruses. Prophylactic administration of VIS410 resulted in the complete protection of mice against lethal A(H7N9) virus challenge. A single therapeutic dose of VIS410 given 24 h after virus inoculation resulted in dose-dependent protection of up to 100% of mice inoculated with neuraminidase inhibitor-susceptible or -resistant A(H7N9) viruses. Compared to the outcomes in mock-treated controls, a single administration of VIS410 improved viral clearance from the lungs, reduced virus spread in lungs in a dose-dependent manner, resulting in a lower lung injury score, reduced the extent of the alteration in lung vascular permeability and protein accumulation in bronchoalveolar lavage fluid, and improved lung physiologic function. Thus, antibodies targeting the HA stem can reduce the severity of ARDS and show promise as agents for controlling pulmonary complications in influenza.

scholarly journals Short-term survival of acute respiratory distress syndrome patients due to influenza virus infection alone: a cohort study

2020 ◽  
Vol 6 (4) ◽  
pp. 00587-2020
Author(s):  
Arnaud Gacouin ◽  
Mathieu Lesouhaitier ◽  
Florian Reizine ◽  
Charlotte Pronier ◽  
Murielle Grégoire ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Acute Respiratory Distress Syndrome ◽  
Propensity Score ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Propensity Score Matching ◽  
Distress Syndrome ◽  
Arterial Oxygen ◽  
Term Survival ◽  
The Impact

BackgroundInfluenza virus (IV)-related pathophysiology suggests that the prognosis of acute respiratory distress syndrome (ARDS) due to IV could be different from the prognosis of ARDS due to other causes. However, the impact of IV infection alone on the prognosis of ARDS patients compared to that of patients with other causes of ARDS has been poorly assessed.MethodsWe compared the 28-day survival from the diagnosis of ARDS with an arterial oxygen tension/inspiratory oxygen fraction ratio ≤150 mmHg between patients with and without IV infection alone. Data were collected prospectively and analysed retrospectively. We first performed survival analysis on the whole population; second, patients with IV infection alone were compared with matched pairs using propensity score matching.ResultsThe cohort admitted from October 2009 to March 2020 consisted of 572 patients, including 73 patients (13%) with IV alone. On the first 3 days of mechanical ventilation, nonpulmonary Sequential Organ Failure Assessment scores were significantly lower in patients with IV infection than in the other patients. After the adjusted analysis, IV infection alone remained independently associated with lower mortality at day 28 (hazard ratio 0.51, 95% CI 0.26–0.99, p=0.047). Mortality at day 28 was significantly lower in patients with IV infection alone than in other patients when propensity score matching was used (20% versus 38%, p=0.02).ConclusionsOur results suggest that patients with ARDS following IV infection alone have a significantly better prognosis at day 28 and less severe nonpulmonary organ dysfunction than do those with ARDS from causes other than IV infection alone.

scholarly journals Two Cases of Seasonal Influenza Virus (H3N2) and Acute Respiratory Distress Syndrome

2016 ◽  
Vol 22 (2) ◽  
pp. 124-128
Author(s):  
Moo Hyun Kim ◽  
Bo Ra Yoon ◽  
Myung Jin Song ◽  
Ji Soo Choi ◽  
Sang Hoon Lee ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Seasonal Influenza ◽  
Distress Syndrome
Sign in / Sign up

Export Citation Format

Share Document