scholarly journals Notch3 Knockout Suppresses Mouse Mammary Gland Development and Inhibits the Proliferation of 4T1 Murine Mammary Carcinoma Cells via CCL2/CCR4 Axis

2020 ◽  
Vol 8 ◽  
Author(s):  
Wei Xiong ◽  
Junyu Tan ◽  
Yuxian Guo ◽  
Shuzhao Chen ◽  
Liping Fan ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Carcinoma ◽  
Mammary Gland Development ◽  
Mouse Mammary Gland ◽  
Carcinoma Cells ◽  
Mammary Carcinoma Cells ◽  
Gland Development ◽  
Murine Mammary Carcinoma

scholarly journals Expression of Terminal Differentiation Proteins Defines Stages of Mouse Mammary Gland Development

2006 ◽  
Vol 43 (1) ◽  
pp. 36-49 ◽  
Author(s):  
I. Mikaelian ◽  
M. Hovick ◽  
K. A. Silva ◽  
L. M. Burzenski ◽  
L. D. Shultz ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Terminal Differentiation ◽  
Mouse Mammary Gland ◽  
Gland Development

scholarly journals Landscape of genomic imprinting and its functions in the mouse mammary gland

2020 ◽  
Author(s):  
Haibo Xu ◽  
Lina Zhao ◽  
Xu Feng ◽  
Yujie Ma ◽  
Wei Chen ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Genomic Imprinting ◽  
Growth Regulation ◽  
Mammary Gland Development ◽  
Epigenetic Modification ◽  
Meta Analysis ◽  
Mouse Mammary Gland ◽  
Sequencing Data ◽  
Functional Studies ◽  
Gland Development

Abstract Genomic imprinting is an epigenetic modification of DNA, whereby gene expression is restricted to either maternally or paternally inherited alleles. Imprinted genes (IGs) in the placenta and embryo are essential for growth regulation and nutrient supply. However, despite being an important nutrition delivery organ, studies on mammary gland genomic imprinting remain limited. In this study, we found that both the number of IGs and their expression levels decreased during development of the mouse mammary gland. IG expression was lineage-specific and related to mammary gland development and lactation. Meta-analysis of single-cell RNA sequencing data revealed that mammary gland IGs were co-expressed in a network that regulated cell stemness and differentiation, which was confirmed by our functional studies. Accordingly, our data indicated that IGs were essential for the self-renewal of mammary gland stem cells and IG decline was correlated with mammary gland maturity. Taken together, our findings revealed the importance of IGs in a poorly studied nutrition-related organ, i.e. the mammary gland, thus providing a reference for further studies on genomic imprinting.

scholarly journals Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

Oncogene ◽  
2014 ◽  
Vol 34 (27) ◽  
pp. 3514-3526 ◽  
Author(s):  
J Dembowy ◽  
H A Adissu ◽  
J C Liu ◽  
E Zacksenhaus ◽  
J R Woodgett
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Glycogen Synthase ◽  
Mouse Mammary Gland ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Gland Development

miR-212 and miR-132 are dispensable for mouse mammary gland development

2014 ◽  
Vol 46 (8) ◽  
pp. 804-805 ◽  
Author(s):  
Ahmet Ucar ◽  
Erdem Erikci ◽  
Olga Ucar ◽  
Kamal Chowdhury
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Mouse Mammary Gland ◽  
Gland Development
Sign in / Sign up

Export Citation Format

Share Document