scholarly journals Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

Oncogene ◽  
2014 ◽  
Vol 34 (27) ◽  
pp. 3514-3526 ◽  
Author(s):  
J Dembowy ◽  
H A Adissu ◽  
J C Liu ◽  
E Zacksenhaus ◽  
J R Woodgett
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Glycogen Synthase ◽  
Mouse Mammary Gland ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Gland Development

scholarly journals Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis

2013 ◽  
Author(s):  
Joanna Dembowy ◽  
Hibret A Adissu ◽  
Jeff C Liu ◽  
Eldad Zacksenhaus ◽  
James Robert Woodgett
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Glycogen Synthase ◽  
Mammary Epithelium ◽  
Intraepithelial Neoplasia ◽  
Tumor Formation ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Normal Mammary Gland ◽  
Gland Development

Many components of Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epithelium results in activation of Wnt/β-catenin signaling and induces mammary intraepithelial neoplasia that progresses to squamous transdifferentiation and development of adenosquamous carcinomas at 6 months. To uncover possible β-catenin-independent activities of GSK-3, we generated mammary-specific knock-outs of GSK-3 and β-catenin. Squamous transdifferentiation of the mammary epithelium was largely attenuated, however mammary epithelial cells lost the ability to form mammospheres suggesting perturbation of stem cell properties unrelated to loss of β-catenin alone. At 10 months, adenocarcinomas that developed in glands lacking GSK-3 and β-catenin displayed elevated levels of γ-catenin/plakoglobin as well as activation of the Hedgehog and Notch pathways. Collectively these results establish the two isoforms of GSK-3 as essential integrators of multiple developmental signals that act to maintain normal mammary gland function and suppress tumorigenesis.

scholarly journals Expression of Terminal Differentiation Proteins Defines Stages of Mouse Mammary Gland Development

2006 ◽  
Vol 43 (1) ◽  
pp. 36-49 ◽  
Author(s):  
I. Mikaelian ◽  
M. Hovick ◽  
K. A. Silva ◽  
L. M. Burzenski ◽  
L. D. Shultz ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Terminal Differentiation ◽  
Mouse Mammary Gland ◽  
Gland Development

scholarly journals Landscape of genomic imprinting and its functions in the mouse mammary gland

2020 ◽  
Author(s):  
Haibo Xu ◽  
Lina Zhao ◽  
Xu Feng ◽  
Yujie Ma ◽  
Wei Chen ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Genomic Imprinting ◽  
Growth Regulation ◽  
Mammary Gland Development ◽  
Epigenetic Modification ◽  
Meta Analysis ◽  
Mouse Mammary Gland ◽  
Sequencing Data ◽  
Functional Studies ◽  
Gland Development

Abstract Genomic imprinting is an epigenetic modification of DNA, whereby gene expression is restricted to either maternally or paternally inherited alleles. Imprinted genes (IGs) in the placenta and embryo are essential for growth regulation and nutrient supply. However, despite being an important nutrition delivery organ, studies on mammary gland genomic imprinting remain limited. In this study, we found that both the number of IGs and their expression levels decreased during development of the mouse mammary gland. IG expression was lineage-specific and related to mammary gland development and lactation. Meta-analysis of single-cell RNA sequencing data revealed that mammary gland IGs were co-expressed in a network that regulated cell stemness and differentiation, which was confirmed by our functional studies. Accordingly, our data indicated that IGs were essential for the self-renewal of mammary gland stem cells and IG decline was correlated with mammary gland maturity. Taken together, our findings revealed the importance of IGs in a poorly studied nutrition-related organ, i.e. the mammary gland, thus providing a reference for further studies on genomic imprinting.

miR-212 and miR-132 are dispensable for mouse mammary gland development

2014 ◽  
Vol 46 (8) ◽  
pp. 804-805 ◽  
Author(s):  
Ahmet Ucar ◽  
Erdem Erikci ◽  
Olga Ucar ◽  
Kamal Chowdhury
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Mouse Mammary Gland ◽  
Gland Development

Estrogen receptor-negative epithelial cells in mouse mammary gland development and growth

1998 ◽  
Vol 62 (5) ◽  
pp. 221-226 ◽  
Author(s):  
Nikolajs Zeps ◽  
Jacqueline M. Bentel ◽  
John M. Papadimitriou ◽  
Mario F. D'Antuono ◽  
Hugh J.S. Dawkins
Keyword(s):  
Estrogen Receptor ◽  
Mammary Gland ◽  
Epithelial Cells ◽  
Mammary Gland Development ◽  
Mouse Mammary Gland ◽  
Gland Development ◽  
Estrogen Receptor Negative

scholarly journals DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis

2019 ◽  
Vol 455 (1) ◽  
pp. 42-50
Author(s):  
Chunling Tang ◽  
Renske J.E. van den Bijgaart ◽  
Maaike W.G. Looman ◽  
Nina Tel-Karthaus ◽  
Annemarie M.A. de Graaf ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Branching Morphogenesis ◽  
Mouse Mammary Gland ◽  
Gland Development
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