scholarly journals Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors

2020 ◽  
Vol 8 ◽  
Author(s):  
Marcella Martinelli ◽  
Annalisa Palmieri ◽  
Francesco Carinci ◽  
Luca Scapoli
Keyword(s):  
Risk Factors ◽  
Cleft Palate ◽  
Environmental Risk ◽  
Environmental Risk Factors

Genetic and environmental risk factors for submucous cleft palate

2012 ◽  
Vol 120 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Rudolf Reiter ◽  
Sibylle Brosch ◽  
Manuel Lüdeke ◽  
Elena Fischbein ◽  
Stephan Haase ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cleft Palate ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Submucous Cleft Palate

Incidence of Cleft Pathology in Greater New Orleans before and after Hurricane Katrina

2011 ◽  
Vol 48 (6) ◽  
pp. 757-761 ◽  
Author(s):  
Haig A. Goenjian ◽  
Ernest S. Chiu ◽  
Mary Ellen Alexander ◽  
Hugo St. Hilaire ◽  
Michael Moses
Keyword(s):  
Risk Factors ◽  
African Americans ◽  
Cleft Palate ◽  
Hurricane Katrina ◽  
New Orleans ◽  
Environmental Risk ◽  
Cleft Lip ◽  
Environmental Risk Factors ◽  
Stress Reactions ◽  
Before And After

Background Reports after the 2005 Hurricane Katrina have documented an increase in stress reactions and environmental teratogens (arsenic, mold, alcohol). Objective To assess the incidence of cleft pathology before and after the hurricane, and the distribution of cleft cases by gender and race. Methods Retrospective chart review of cleft lip with or without cleft palate (CUP) and cleft palate (CP) cases registered with the Cleft and Craniofacial Team at Children's Hospital of New Orleans, the surgical center that treated cleft cases in Greater New Orleans between 2004 and 2007. Live birth data were obtained from the Louisiana State Center for Health Statistics. Results The incidence of cleft cases, beginning 9 months after the hurricane (i.e., June 1, 2006) was significantly higher compared with the period before the hurricane (0.80 versus 1.42; p = .008). Within racial group comparisons showed a higher incidence among African Americans versus whites (0.42 versus 1.22; p = .01). The distribution of CUP and CP cases by gender was significant ( p = .05). Conclusion The increase in the incidence of cleft cases after the hurricane may be attributable to increased stress and teratogenic factors associated with the hurricane. The increase among African Americans may have been due to comparatively higher exposure to environmental risk factors. These findings warrant further investigation to replicate the results elsewhere in the Gulf to determine whether there is a causal relationship between environmental risk factors and increased cleft pathology.

Environmental Risk Factors for Nonsyndromic Cleft Lip and/or Cleft Palate in Xinjiang Province, China: A Multiethnic Study

2020 ◽  
pp. 105566562095686
Author(s):  
Yu Hong ◽  
Xianrong Xu ◽  
Fuzhi Lian ◽  
Rong Chen
Keyword(s):  
Risk Factors ◽  
Cleft Palate ◽  
Environmental Risk ◽  
Cleft Lip ◽  
Pesticide Exposure ◽  
Characteristic Curve ◽  
Environmental Risk Factors ◽  
Physical Workload ◽  
Lifestyle Behaviors ◽  
Increased Risk

Objective: To determine the risk factors of the occurrence of nonsyndromic cleft lip and/or cleft palate (NSCL/P) in Xinjiang Province, China. Design: The study included 359 patients of NSCL/P and 310 controls. Information about sociodemographic characteristics, lifestyle behaviors, negative life events, possible environmental hazards exposures, and use of supplementations were collected from cases and controls. Both t test and χ2 tests were used for group comparisons. Multivariable logistic regression was used to estimate the independent associations between environmental risk factors and the presence of NSCL/P. The receiver operating characteristic curve was used to establish the predictive variables for the occurrence of NSCL/P. Results: The results showed that maternal pesticide exposure (odds ratio [OR] = 11.40, 95%CI: 5.40-24.10), antibiotic drugs use (OR = 1.32, 95%CI: 1.14-1.53), paternal smoking (OR = 3.30, 95%CI: 1.87-5.83), threatened abortion (OR = 12.2, 95%CI: 3.29-45.25) were associated with increased risk of NSCL/P in offspring. In contrast, maternal moderate (OR = 0.43, 95%CI: 0.20-0.92) and middle physical workload (OR = 0.48, 95%CI: 0.0.23-0.97), vitamin-B complex supplementations (OR = 0.11, 95%CI: 0.03-0.41), calcium and iron (OR = 0.27, 95%CI: 0.08-0.90) supplementations were associated with reduced risk of NSCL/P in offspring. These variables together explain nearly 60% of the variation of occurrence of NSCL/P. Conclusion: These findings from our study may help to develop primary prevention strategies for NSCL/P in Xinjiang.

Self-Control As a Moderator for Environmental Risk Factors

2010 ◽  
Author(s):  
Thomas A. Wills ◽  
Pallav Pokhrel ◽  
Frederick X. Gibbons ◽  
James D. Sargent ◽  
Mike Stoolmiller
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Self Control

Environmental Risk Factors in Multiple Sclerosis Questionnaire

2012 ◽  
Author(s):  
M. Pugliatti ◽  
I. Casetta ◽  
J. Drulovic ◽  
E. Granieri ◽  
T. Holmøy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Environmental Risk ◽  
Environmental Risk Factors

Genetic and Environmental Risk Factors for Alcoholism: A 16-Year Longitudinal Cohort Study

2019 ◽  
Author(s):  
I-Chao Liu ◽  
Shu-Fen Liao ◽  
Lawrence Shih-Hsin ◽  
Susan Shur-Fen Gau ◽  
Wen-Chung Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort
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