Genetic and Environmental Risk Factors for Cleft Lip and Cleft Palate

2015 ◽  
Keyword(s):  
Risk Factors ◽  
Cleft Palate ◽  
Environmental Risk ◽  
Cleft Lip ◽  
Environmental Risk Factors

Incidence of Cleft Pathology in Greater New Orleans before and after Hurricane Katrina

2011 ◽  
Vol 48 (6) ◽  
pp. 757-761 ◽  
Author(s):  
Haig A. Goenjian ◽  
Ernest S. Chiu ◽  
Mary Ellen Alexander ◽  
Hugo St. Hilaire ◽  
Michael Moses
Keyword(s):  
Risk Factors ◽  
African Americans ◽  
Cleft Palate ◽  
Hurricane Katrina ◽  
New Orleans ◽  
Environmental Risk ◽  
Cleft Lip ◽  
Environmental Risk Factors ◽  
Stress Reactions ◽  
Before And After

Background Reports after the 2005 Hurricane Katrina have documented an increase in stress reactions and environmental teratogens (arsenic, mold, alcohol). Objective To assess the incidence of cleft pathology before and after the hurricane, and the distribution of cleft cases by gender and race. Methods Retrospective chart review of cleft lip with or without cleft palate (CUP) and cleft palate (CP) cases registered with the Cleft and Craniofacial Team at Children's Hospital of New Orleans, the surgical center that treated cleft cases in Greater New Orleans between 2004 and 2007. Live birth data were obtained from the Louisiana State Center for Health Statistics. Results The incidence of cleft cases, beginning 9 months after the hurricane (i.e., June 1, 2006) was significantly higher compared with the period before the hurricane (0.80 versus 1.42; p = .008). Within racial group comparisons showed a higher incidence among African Americans versus whites (0.42 versus 1.22; p = .01). The distribution of CUP and CP cases by gender was significant ( p = .05). Conclusion The increase in the incidence of cleft cases after the hurricane may be attributable to increased stress and teratogenic factors associated with the hurricane. The increase among African Americans may have been due to comparatively higher exposure to environmental risk factors. These findings warrant further investigation to replicate the results elsewhere in the Gulf to determine whether there is a causal relationship between environmental risk factors and increased cleft pathology.

Environmental Risk Factors for Nonsyndromic Cleft Lip and/or Cleft Palate in Xinjiang Province, China: A Multiethnic Study

2020 ◽  
pp. 105566562095686
Author(s):  
Yu Hong ◽  
Xianrong Xu ◽  
Fuzhi Lian ◽  
Rong Chen
Keyword(s):  
Risk Factors ◽  
Cleft Palate ◽  
Environmental Risk ◽  
Cleft Lip ◽  
Pesticide Exposure ◽  
Characteristic Curve ◽  
Environmental Risk Factors ◽  
Physical Workload ◽  
Lifestyle Behaviors ◽  
Increased Risk

Objective: To determine the risk factors of the occurrence of nonsyndromic cleft lip and/or cleft palate (NSCL/P) in Xinjiang Province, China. Design: The study included 359 patients of NSCL/P and 310 controls. Information about sociodemographic characteristics, lifestyle behaviors, negative life events, possible environmental hazards exposures, and use of supplementations were collected from cases and controls. Both t test and χ2 tests were used for group comparisons. Multivariable logistic regression was used to estimate the independent associations between environmental risk factors and the presence of NSCL/P. The receiver operating characteristic curve was used to establish the predictive variables for the occurrence of NSCL/P. Results: The results showed that maternal pesticide exposure (odds ratio [OR] = 11.40, 95%CI: 5.40-24.10), antibiotic drugs use (OR = 1.32, 95%CI: 1.14-1.53), paternal smoking (OR = 3.30, 95%CI: 1.87-5.83), threatened abortion (OR = 12.2, 95%CI: 3.29-45.25) were associated with increased risk of NSCL/P in offspring. In contrast, maternal moderate (OR = 0.43, 95%CI: 0.20-0.92) and middle physical workload (OR = 0.48, 95%CI: 0.0.23-0.97), vitamin-B complex supplementations (OR = 0.11, 95%CI: 0.03-0.41), calcium and iron (OR = 0.27, 95%CI: 0.08-0.90) supplementations were associated with reduced risk of NSCL/P in offspring. These variables together explain nearly 60% of the variation of occurrence of NSCL/P. Conclusion: These findings from our study may help to develop primary prevention strategies for NSCL/P in Xinjiang.

Genetic and environmental risk factors for submucous cleft palate

2012 ◽  
Vol 120 (2) ◽  
pp. 97-103 ◽  
Author(s):  
Rudolf Reiter ◽  
Sibylle Brosch ◽  
Manuel Lüdeke ◽  
Elena Fischbein ◽  
Stephan Haase ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cleft Palate ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Submucous Cleft Palate

scholarly journals Environmental risk factors for cleft lip and palate in low-resource settings: a case-control study

2019 ◽  
Vol 7 ◽  
pp. S19
Author(s):  
Allyn Auslander ◽  
Roberta Mckean-Cowdin ◽  
Frederick Brindopke ◽  
Kathy Magee ◽  
Melissa DiBona ◽  
...  
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Cleft Lip ◽  
Case Control Study ◽  
Cleft Lip And Palate ◽  
Case Control ◽  
Environmental Risk Factors ◽  
Low Resource Settings ◽  
Low Resource ◽  
Control Study

Cleft Lip and/or Palate and Associated Risks in Lower-Middle-Income Countries: A Systematic Review

2021 ◽  
pp. 105566562110189
Author(s):  
Kayla Kruppa ◽  
Esedra Krüger ◽  
Carlien Vorster ◽  
Jeannie van der Linde
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Environmental Risk ◽  
Early Identification ◽  
Cleft Lip ◽  
Environmental Risk Factors ◽  
Paternal Age ◽  
Published Data ◽  
Middle Income ◽  
Middle Income Countries

Objective: To identify and review published data on the risks associated with cleft lip and/or palate (CL/P) in lower-middle-income countries (LMICs). Design: A systematic review of literature was performed on electronic databases using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. Literature on risks associated with CL/P in LMICs, from 2010 to 2020, were included. Results: Seventeen studies met the inclusion criteria. All studies adopted an observational study design. Biological and environmental risks were identified. Maternal and paternal age (n = 7) and low socioeconomic status (n = 5) were the most prominently associated environmental risk factors. A strong association was identified between family history of cleft (n = 7) and CL/P occurrence. Conclusion: Environmental risk factors are now being investigated more than biological risk factors in LMICs, aiding health care workers in the early identification of possible cumulative effects of risks in CL/P. Contextually relevant tools are recommended to promote early identification of at-risk infants.

scholarly journals Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors

2020 ◽  
Vol 8 ◽  
Author(s):  
Marcella Martinelli ◽  
Annalisa Palmieri ◽  
Francesco Carinci ◽  
Luca Scapoli
Keyword(s):  
Risk Factors ◽  
Cleft Palate ◽  
Environmental Risk ◽  
Environmental Risk Factors

Self-Control As a Moderator for Environmental Risk Factors

2010 ◽  
Author(s):  
Thomas A. Wills ◽  
Pallav Pokhrel ◽  
Frederick X. Gibbons ◽  
James D. Sargent ◽  
Mike Stoolmiller
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Self Control

Environmental Risk Factors in Multiple Sclerosis Questionnaire

2012 ◽  
Author(s):  
M. Pugliatti ◽  
I. Casetta ◽  
J. Drulovic ◽  
E. Granieri ◽  
T. Holmøy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Environmental Risk ◽  
Environmental Risk Factors
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