scholarly journals Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum

2019 ◽  
Vol 7 ◽  
Author(s):  
Jonathan Boulanger-Weill ◽  
Germán Sumbre
Keyword(s):  
Optic Tectum ◽  
Functional Integration ◽  
Newborn Neurons ◽  
Zebrafish Optic Tectum

scholarly journals Targeting the Zebrafish Optic Tectum Using In Vivo Electroporation

2010 ◽  
Vol 2010 (7) ◽  
pp. pdb.prot5463-pdb.prot5463 ◽  
Author(s):  
K. J. Hoegler ◽  
J. H. Horne
Keyword(s):  
Optic Tectum ◽  
In Vivo Electroporation ◽  
Zebrafish Optic Tectum

scholarly journals Valproic acid, a histone deacetylase inhibitor, regulates cell proliferation in the adult zebrafish optic tectum

2014 ◽  
Vol 243 (11) ◽  
pp. 1401-1415 ◽  
Author(s):  
Miki Dozawa ◽  
Hiromitsu Kono ◽  
Yuki Sato ◽  
Yoko Ito ◽  
Hideomi Tanaka ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cell Proliferation ◽  
Histone Deacetylase ◽  
Optic Tectum ◽  
Histone Deacetylase Inhibitor ◽  
Adult Zebrafish ◽  
Deacetylase Inhibitor ◽  
Zebrafish Optic Tectum

scholarly journals Adult dentate gyrus neurogenesis: a functional model

2019 ◽  
Author(s):  
Olivia Gozel ◽  
Wulfram Gerstner
Keyword(s):  
Theoretical Model ◽  
Dentate Gyrus ◽  
Granule Cells ◽  
Functional Integration ◽  
Functional Model ◽  
Behavioral Pattern ◽  
Pattern Separation ◽  
Cell Maturation ◽  
Newborn Cell ◽  
Newborn Neurons

SummaryIn adult dentate gyrus neurogenesis, the link between maturation of newborn neurons and their function, such as behavioral pattern separation, has remained puzzling. By analyzing a theoretical model, we show that the switch from excitation to inhibition of the GABAergic input onto maturing newborn cells is crucial for their proper functional integration. When the GABAergic input is excitatory, cooperativity drives the growth of synapses such that newborn cells become sensitive to stimuli similar to those that activate mature cells. When GABAergic input switches to inhibitory, competition pushes the configuration of synapses onto newborn cells towards stimuli that are different from previously stored ones. This enables the maturing newborn cells to code for concepts that are novel, yet similar to familiar ones. Our theory of newborn cell maturation explains both how adult-born dentate granule cells integrate into the preexisting network and why they promote separation of similar but not distinct patterns.

Protocadherins control the modular assembly of neuronal columns in the zebrafish optic tectum

2015 ◽  
Vol 212 (13) ◽  
pp. 21213OIA114
Author(s):  
Sharon R. Cooper ◽  
Michelle R. Emond ◽  
Phan Q. Duy ◽  
Brandon G. Liebau ◽  
Marc A. Wolman ◽  
...  
Keyword(s):  
Optic Tectum ◽  
Modular Assembly ◽  
Zebrafish Optic Tectum

scholarly journals Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning

2013 ◽  
Vol 110 (17) ◽  
pp. 7062-7067 ◽  
Author(s):  
A. Veyrac ◽  
A. Gros ◽  
E. Bruel-Jungerman ◽  
C. Rochefort ◽  
F. B. Kleine Borgmann ◽  
...  
Keyword(s):  
Functional Integration ◽  
Newborn Neurons

Involvement of sonic hedgehog and notch signaling in regenerative neurogenesis in adult zebrafish optic tectum after stab injury

2018 ◽  
Vol 526 (15) ◽  
pp. 2360-2372 ◽  
Author(s):  
Yuto Ueda ◽  
Yuki Shimizu ◽  
Nobuyuki Shimizu ◽  
Tohru Ishitani ◽  
Toshio Ohshima
Keyword(s):  
Notch Signaling ◽  
Sonic Hedgehog ◽  
Optic Tectum ◽  
Adult Zebrafish ◽  
Stab Injury ◽  
Zebrafish Optic Tectum

Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior

2012 ◽  
Vol 18 (9) ◽  
pp. 993-1005 ◽  
Author(s):  
C P Fitzsimons ◽  
L W A van Hooijdonk ◽  
M Schouten ◽  
I Zalachoras ◽  
V Brinks ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Functional Integration ◽  
Motivated Behavior ◽  
Adult Hippocampus ◽  
Newborn Neurons
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