scholarly journals Aberrations of DNA Repair Pathways in Prostate Cancer: Future Implications for Clinical Practice?

2018 ◽  
Vol 6 ◽  
Author(s):  
Orazio Caffo ◽  
Antonello Veccia ◽  
Stefania Kinspergher ◽  
Mimma Rizzo ◽  
Francesca Maines
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Clinical Practice ◽  
Repair Pathways

Germline and Somatic Defects in DNA Repair Pathways in Prostate Cancer

2019 ◽  
pp. 279-300 ◽  
Author(s):  
Sara Arce ◽  
Alejandro Athie ◽  
Colin C. Pritchard ◽  
Joaquin Mateo
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Repair Pathways

scholarly journals Gut Microbiota Dysbiosis Accelerates Prostate Cancer Progression Through Increased LPCAT1 Expression and Enhanced DNA Repair Pathways

2021 ◽  
Vol 11 ◽  
Author(s):  
Yufei Liu ◽  
Chen Yang ◽  
Zheyu Zhang ◽  
Haowen Jiang
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Gut Microbiota ◽  
Cancer Progression ◽  
Fecal Microbiota Transplantation ◽  
Gene Set Enrichment Analysis ◽  
Castration Resistant Prostate Cancer ◽  
Fecal Suspension ◽  
Repair Pathways ◽  
Gut Microbiota Dysbiosis

Gut microbiota dysbiosis is related to cancer development and progression. Our previous study showed that Ruminococcus was more abundant in CRPC (Castration-resistant prostate cancer) than HSPC (Hormone-sensitive prostate cancer) individuals. Here, we determined the potential mechanism of microbiota dysbiosis in prostate cancer (PCa) progression. Metagenomics was used to verify the gut microbial discrepancies between CRPC and HSPC individuals. Fecal microbiota transplantation (FMT) was performed by transferring the fecal suspension of CRPC or HSPC individuals to TRAMP mice. Afterwards, the mice’s prostate histopathology and gut microbiota composition were determined. Since Ruminococcus was demonstrated to correlate with phospholipid metabolism, we used lipidomics to examine the mice’s fecal lipid profiles. The expression of LPCAT1 the key enzyme for phospholipid remodeling in mice prostate was also examined. Meanwhile, both microbial functions prediction and LPCAT1 GSEA analysis (Gene Set Enrichment Analysis) indicated DNA repair pathways, we further determined the expressions of RAD51 and DNA-PKcs in mice prostate. The results showed that gut Ruminococcus was significantly more abundant in CRPC individuals. FMT using CRPC feces accelerated mice’s PCa progression and increased their gut Ruminococcus abundance. Majority of fecal lipids including lysophosphatidylcholine and phosphatidylcholine were upregulated in CRPC FMT treated mice, accompanied with enhanced expressions of LPCAT1, RAD51, and DNA-PKcs in mice prostate. We reported an abundant colonization of Ruminococcus in the gut of CRPC individuals and mice receiving their fecal suspensions, and revealed the promotive capability of Ruminococcus in PCa progression via upregulating LPCAT1 and DNA repair protein expressions. The bacterium and its downstream pathways may become the targets of therapies for PCa in the future.

scholarly journals Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Thais Sobanski ◽  
Maddison Rose ◽  
Amila Suraweera ◽  
Kenneth O’Byrne ◽  
Derek J. Richard ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Clinical Practice ◽  
Chromatin Remodeling ◽  
Metabolic Pathways ◽  
Cell Metabolism ◽  
Therapeutic Interventions ◽  
Dna Repair Proteins ◽  
Normal Human ◽  
Repair Pathways

DNA repair and metabolic pathways are vital to maintain cellular homeostasis in normal human cells. Both of these pathways, however, undergo extensive changes during tumorigenesis, including modifications that promote rapid growth, genetic heterogeneity, and survival. While these two areas of research have remained relatively distinct, there is growing evidence that the pathways are interdependent and intrinsically linked. Therapeutic interventions that target metabolism or DNA repair systems have entered clinical practice in recent years, highlighting the potential of targeting these pathways in cancer. Further exploration of the links between metabolic and DNA repair pathways may open new therapeutic avenues in the future. Here, we discuss the dependence of DNA repair processes upon cellular metabolism; including the production of nucleotides required for repair, the necessity of metabolic pathways for the chromatin remodeling required for DNA repair, and the ways in which metabolism itself can induce and prevent DNA damage. We will also discuss the roles of metabolic proteins in DNA repair and, conversely, how DNA repair proteins can impact upon cell metabolism. Finally, we will discuss how further research may open therapeutic avenues in the treatment of cancer.

scholarly journals Aberrations of DNA repair pathways in prostate cancer: A cornerstone of precision oncology

2021 ◽  
Author(s):  
Stergios Boussios ◽  
Elie Rassy ◽  
Sidrah Shah ◽  
Evangelia Ioannidou ◽  
Matin Sheriff ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Precision Oncology ◽  
Repair Pathways

259: Dna-Repair Genetic Polymorphisms and Prostate Cancer Risk

2005 ◽  
Vol 173 (4S) ◽  
pp. 71-71
Author(s):  
Peter E. Clark ◽  
M. Craig Hall ◽  
Kristin L. Lockett ◽  
Jianfeng Xu ◽  
Sigun L. Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Prostate Cancer Risk
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